Currently, one of the most frequent diseases in children is a herpetic infection, which is explained not only by the prevalence of herpes simplex virus (HSV), but also by the peculiarities of the development of the immune system in a developing child's body. Questions of the general status of herpetic stomatitis in children is important. The purpose of the study was to study the immunological parameters of the oral cavity in children with acute herpetic stomatitis in the dynamics before and after treatment with Kyzyl May. In 62 children with acute herpetic stomatitis who applied to the department of pediatric therapeutic dentistry at TSDI, clinical and immunological studies were conducted. Based on the obtained clinical and immunological data, the high efficacy of Kyzyl May is effective in the treatment of acute herpetic stomatitis.