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490
TECHNOLOGIES FOR MANUFACTURING FILAMENTS AND SCAFFOLDS USED
IN MEDICINE USING SILK FIBER WASTES.
Shavkatov Otabek Kozimbek ugli
Andijan State Technical Institute
Department of Metrology and Light Industry
Trainee Teacher,
Email:
tel:+998943884443
Annotation:
This article reviews the scientific and practical foundations of using silk fiber waste
in the production of filaments and scaffolds used in biomedicine. Silk fiber, as a natural
biomaterial, has high biocompatibility, biodegradability and mechanical strength. Therefore,
economic and ecologically effective solutions are proposed for regenerative medicine, tissue
engineering and the creation of implants by recycling silk waste. The article discusses the
technologies for processing silk waste, their physicochemical characteristics, as well as the
possibilities of creating scaffolds using modern 3D bioprinters.
Keywords:
Silk fiber, filament, scaffold, electrospinning, freeze-drying, 3D printing, cell
cultures, skin regeneration, bone regeneration, implants and prostheses.
Introduction.
In recent years, the use of biomaterials based on natural sources in tissue
regeneration, artificial organ development, and regenerative medicine has become a hot topic in
the field of biomedicine. Silk fiber is one of the materials widely used in biomedicine due to its
natural and ecological aspects. Since silk fiber contains high-quality proteins such as collagen
and elastin, it has the potential to be used in medicine, especially in regenerative medicine.
However, the industrial production and use of silk fibers often raises problems related to
resources and cost-effectiveness. Therefore, the production of filaments and scaffolds used in
biomedicine from silk fiber waste opens up new opportunities for the development of
environmentally friendly and innovative technologies. [1]
The role of silk fibers in biomedicine
The widespread use of silk fibers in biomedicine is due to their biological properties. Silk fibers
are considered a very suitable material for use in biomedicine, due to their high mechanical
strength, elasticity, biological stability, biocompatibility and degradability. The molecular
structure of silk fibers includes proteins similar to collagen and elastin, which make them ideal
materials for supporting cell growth and regeneration. In biomedicine, they are used, in
particular, in the regeneration of skin, bone, and other tissues, in the development of implants
and prostheses, as well as in the modification of drugs, which ensures their easy processing in
the human div. [2]
Use of silk fiber waste
One of the main advantages of converting silk fiber waste into filaments and scaffolds for use in
biomedicine is that it is environmentally friendly. Silk waste is usually a material left over from
silk production processes or from the production of silk fiber. This is an effective way to recycle
waste and transform it into high-tech materials, protecting the environment. [3] That is, it is
possible to effectively use the waste generated during the creation of silk fibers, while protecting
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them from various factors that can harm the environment, and to produce useful products. In this
way, the transformation of waste into high-value biomedical materials helps to save natural
resources and prevent their unnecessary loss. [4]
Filament and scaffold production
Several technological processes are required to produce filaments and scaffolds from silk fiber
waste. First, the silk fibers in the waste must undergo a cleaning process. These processes can be
carried out by biological or chemical methods. The silk fibers are then cut into various sizes and
shapes, and their mechanical and biochemical properties are evaluated to verify their quality. [5]
Filaments are continuous or fragmented fibers that can be produced to provide a 3D environment
for biological tissues and cells. Filaments have a microscopic structure that helps cells grow.
Scaffolds, on the other hand, are materials that form a 3D structure that creates an ideal growth
environment for cells. When silk fibers are used as scaffolds, their structural properties, such as
the micropores and spaces necessary for cells, create good conditions for tissue growth.
Scaffolds are biocompatible and easy to test and implant in the div. [6]
Several technologies are used to produce filaments and scaffolds from silk fibers, including:
Electrospinning: This technology allows silk fibers to be produced in the form of microfibers
using a high-voltage electric field. During the electrospinning process, the silk polymers are
rapidly aggregated and transformed into fine fibers, which is useful for their use as scaffolds.
Freeze-drying: Silk fibers can be freeze-dried to create structures while maintaining their
biological activity. The freezing process helps to ensure the stability of the scaffolds.
3D printing: Silk fibers can be transformed into scaffolds using 3D printers. This process allows
the creation of precise geometric shapes of scaffolds and helps to produce flexible materials for
various tissues. [7]
The microfiber structure of silk is used in the production of filaments and scaffolds to maintain
their structure, provide support and growth for cells. These materials create a good growth
environment for cell cultures and ultimately help regenerate biological tissues.
Potential areas in biomedicine
Filaments and scaffolds made from silk fiber waste have a number of biomedical applications.
These include:
1. Cell culture: Scaffolds made from silk fiber are used to support the growth and regeneration of
cells into various tissues. The microscopic structures of silk create a good growth environment
for cells, which helps regenerate new tissues. The high surface area and precise structure of silk
fiber create optimal conditions for cell growth.
2. Skin regeneration: Due to the good compatibility of silk fiber with skin tissues, it is used in
skin regeneration. Materials made from silk fiber are used in wound healing and skin grafting
procedures. [8]
3. Bone and muscle regeneration: Silk's high mechanical strength and elasticity make it an ideal
material for scaffolds used in bone and muscle tissue regeneration.
4. Drug delivery systems: Silk is also used to produce microcapsules or nanocapsules for the
efficient delivery of biologically active substances to target organs or tissues.
5. Implants and prostheses: Materials made from silk fibers are used to develop implants and
prostheses for organs and tissues. These materials are harmless, so they are easy to adapt to the
div. [9]
Conclusion
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The production of filaments and scaffolds from silk fiber waste is an important step in creating
innovative materials in biomedicine. This technology is a good way to effectively use waste and
protect the environment, allowing the production of environmentally sustainable and effective
materials, while creating new opportunities in the field of regenerative medicine and implants. It
is also a good example of waste recycling and efficient use of resources, and represents a
promising direction for the future of the biomedical industry.
References.
1.
Shavkatov Otabek, Yodgorbek Ismoiljonov and Zafar Juraev. "DEFINING MEDICAL
DEVICES: A COMPREHENSIVE OVERVIEW." European Journal of Interdisciplinary
Research and Development 25 (2024): 114-118.
2.
Shavkatov O.K. va Tursunboyeva M.A. “ISHLAB CHIQARISHDA TOLANI SIFAT
KO`RSATKICHINI ZAMONAVIY USULLAR BILAN ANIQLASH” Respublika ilmiy-texnik
jurnali (2024): 421-425
3.
Kozimbek o’g’li, Shavkatov Otabek. "TECHNOLOGIES OF USING SILK FIBER
WASTES IN THE PRODUCTION OF FILAMENTS USED IN BIOMEDICINE."
Web of
Medicine: Journal of Medicine, Practice and Nursing
3.2 (2025): 468-471.
4.
Otabek,
Shavkatov.
"EKG
TIBBIYOT
TEXNIKASI
VOSITASINI
EKG
SIMULYATORI YORDAMIDA METROLOGIK ANIQLIGINI OSHIRISH."
Journal of new
century innovations
24.3 (2023): 59-64.
5.
S.Umarov, E.Bozorov, O.Jabborova “Tibbiy texnika va yangi tibbiyot texnologiyasi” Т -
2018.
6.
G.J. Jarilkasinova, D.R. Adizova “Amaliy tibbiyotdagi yangi texnologiyalar” Toshkent -
2012. — 208 b.
7.
Islomiy, Normatov, Isroilov Asadbek, and Otabek Shavkatov. "ENSURING QUALITY
AND SAFETY OF AGRICULTURAL PRODUCTS ON THE BASIS OF INTERNATIONAL
STANDARDS."
Next Scientists Conferences
. 2022.
8.
Ma, Yue, Yaping Liang, and Wenjuan Bi. "Application of Silk Fibroin in the Field of
Oral Clinical Medicine."
International Core Journal of Engineering
8.7 (2022): 561-564.
9.
Raxmonalievna,
Sodiqova
Mahbubaxon.
"ADVANCEMENTS
IN
SILK:
DEVELOPMENT
OF
MANAGEMENT
SYSTEMS
AND
SCIENTIFIC
FOUNDATIONS."
International Journal of Advance Scientific Research
3.06 (2023): 266-271.
