ASSESSMENT OF THE MORPHOFUNCTIONAL STATUS OF THE THYROID GLAND AFTER ADMINISTRATION OF LADIGINOZID AND HEDERAGENIN

A comparative assessment of the effects of ladylginoside and hederagenin on the morph functional status of the thyroid gland was carried out. Ladyginoside is a sum of triterpene glycosides. It was obtained at the laboratory of glycosides of the Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan (Head - Corresponding Member of the Academy of Sciences of Uzbekistan, Professor N.K. Abubakirov) from the plant Ladiginia bucharica, which grows on the territory of Uzbekistan. Hederagenin is a non-sugar part - the aglycone of ladiginoside, obtained there by synthesis and is considered as a possible active ingredient. For the purpose of confirming the assumption in experimental tests, the morphofunctional status of the thyroid gland was evaluated during administration of ladylginoside and hederagenin. The experimental search results proved the fact, that ladyginoside causes changes in morphofunctional indicators of the thyroid gland, indicating an increase in its function. The experimental study revealed that introduction of hederagenin causes shifts of morphofunctional activity of the thyroid gland similar to ladyginoside, which allows, with a high degree of probability, to consider hederagenin as pharmacologically active agent of ladyginoside.