POSSIBILITIES OF CLINICAL USE OF EXTRACELLULAR DNA IN COLORECTAL CANCER

Abstract: Colorectal cancer in recent years has been considered one of the urgent problems of medicine. Considering the development of medical technology, the diagnosis of CRC reaches more than 1.8 million annually, which makes CRC the third most diagnosed among all oncological pathologies, and the mortality rate reaches 881,000 cases and takes second place in this indicator. High mortality is associated with the presence of distant or latent metastases. In recent years, detection of extracellular oncological DNA has played an important role in the diagnosis of colorectal cancer. vcDNA makes it possible to detect the presence of residual cancer with greater accuracy compared to existing laboratory and instrumental diagnostic methods, which makes it possible to choose the need for chemotherapy in the postoperative period.