J Rizaev, K Yunuskhanova
The article focuses on published research that complements the knowledge base and expands our understanding of the clinical and biological links between rheumatoid arthritis and periodontal disease,with links to historical studies and case studies.Since the importance of peptide citrullination as an etiopathological event in rheumatoid arthritis has been elucidated, research has focused on the expression and function of peptidylarginine deiminase (PAD) enzymes,which can lead to post-translational modifi cation,neoepitope formation, followed by the development of anticitrullinated peptide (ACPA). In addition,additional studies of the periodontal microbiome and the immunological mechanisms of periodontal disease have provided additional information. A number of animal studies have been conducted to assess the interaction between periodontal disease and arthritis.Periodontal disease is common, often severe, and is present in all stages of rheumatoid arthritis, including the early stages of the disease. The infl ammatory microenvironment of the periodontium may play a role in the development of rheumatoid arthritis or increase systemic infl ammation and immunity as the disease spreads.
