51
IMPROVING THE TREATMENT OF CHRONIC RECURRENT
AFTHOUS STOMATITIS
Kamilov Kh.P., Kadirbaeva A.A., Bakhramova F.N., Usmanova L.B.
Tashkent state dental institute
Introduction. A correct diagnostic of recurrent aphthous stomatitis (RAS,
sometimes also called recurrent oral ulcers or ulcers) is a central element of dentistry
issues. Aphthous ulcers have been carefully defined so that they can be differentiated
from many other types of recurrent oral ulcers that are not associated with systemic
abnormalities (M.Kh. Ibragimova, 2019). Objectively, the prevalence rate is
incredibly high, but if RAS is defined as more than two spontaneously occurring
episodes per year, then the average prevalence in the population is about 10%, which
seems reasonable. Many studies struggle with definitions and ask if subjects ever
had mouth ulcers. Reported estimates range from 1.5 to 28% in different parts of the
world according to the WHO, suggesting that there may be genetic differences that
account for these geographic differences. Current evidence suggests that RAS may
be the result of an abnormal cascade of cytokines in the oral mucosa, which leads to
a cell-mediated immune response directed to the focal area of the oral mucosa
(Alimova D.M., 2021).
Material and research methods. 30 patients with chronic recurrent aphthous
stomatitis of the oral mucosa were examined at the age of 25-80 years at the
Department of Hospital Therapeutic Dentistry of the Tashkent State Dental Institute,
in 2017-2020. All the patients had RAS treatment using the infrared spectrum of
PDT.
Results. Before treatment, all studied patients complained of pain and
discomfort in the oral cavity, aggravated by the intake of spicy and acidic foods,
75% complained of a burning sensation of the oral cavity, 35% had hypersalivation.
Treatment of patients with PDT led to the complete elimination of complaints
already on the 5th day. As PDT was exposed to the erosive surface, the level of pain
intensity decreased. The most pronounced decrease in the intensity of pain syndrome
was revealed in the first three days from the start of therapy. Their epithelialization
rate averaged 3.5 days. Another important criterion for the effectiveness of HRAS
treatment is the duration of remission, which was 120 ± 21.3 days with the use of 1
course of PDT, after three courses of application it was 146 ± 32.5 days.
Conclusions. Thus, photodynamic therapy can be considered an important key
to improving the treatment of chronic recurrent aphthous stomatitis and indeed
increasing the effectiveness of its treatment.
References:
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52
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THE ROLE OF VITAMIN D IN THE DEVELOPMENT OF
PARODONTAL INFLAMMATORY DISEASES
Kochubeinik A.V., Grechina A.G.
Privolzhsky Research Medical University
Abstract.
Percentage of human population that suffer from chronic
inflammatory parodontal diseases amounts to 70-98% [1]. This group of diseases is
considered to be one of the most common reasons of teeth loss among people over
40 years of age. There are more than 50 somatic pathologies known to date, that get
compounded by damage of parodontal tissues with 100% probability [2].
There is a tendency for «rejuvenation» of parodontal inflammatory diseases,
that results in increasing prevalence among the age group of 18-24 [3]. Another
tendency is that aggressiveness and severity of diagnosed pathologies increases
considerably [4]. Statistically significant prevalence of vitamin D (21-29 ng/ml or
52,5-72,5 nmol/l) and deficiency (11-20 ng/ml or 27,5-50 nmol/l) [5], laboratory
data in an array of research enable us to claim a substantial reverse dependence of
parodontal inflammatory diseases’ intensity on vitamin D levels.
Термином «витамин D» объединяют группу сходных по химическому
строению форм жирорастворимого витамина D (D1- D7), наибольшая роль
принадлежит метаболитам D 2 - эргокальциферола- и D 3 - холекальциферола
кальцидиолу 25(OH)D и кальцитриолу - 1,25(OH)2D. Рецепторы к витамину D
