СБОРНИК ТЕЗИСОВ
5
SPECIFIC PATHOMORPHOLOGICAL CHANGES IN THE COURSE OF LYMPHOCYTIC
LEUKOSIS IN CHILDREN
Masharipova Sh.S.
Urgench branch of Tashkent Medical Academy, Urgench, Uzbekistan
Relevance: Acute lymphoblastic leukosis in children is the most common oncological disease in
children aged 2-5 years. The main clinical-morphological sign is the multiple production of lymphocytic
cells from bone Burrow. The disease is very severe, often ending in death. Therefore, it is considered
important to identify and know the initial primary symptoms of the disease. Each year, 50 out of a million
children are infected with the disease.
The purpose of the work. Taking into account these discussions, the identification of specific
pathomorphological changes in the disease of young children limfoleicosis was taken as the main goal of
the article.
Material and methods. For the last 10 years (2008-2018) to achieve the goal, the autopsy material of
children who died of limfoleicosis was comprehensively studied at the Republican Institute of scientific
investigation of Hematology and blood transfusion. During this period, a total of 1,568 sick children were
treated with lymphocytic leukosis in the clinic of this Institute, of which 74 died. Of these, 47 are girls
and 67 are boys. By age: 12 died under the age of 2, 28 died under the age of 4, 26 died under the age of
6, and 18 died under the age of 10. The history of the disease of the dead, laboratory examination data,
an autopsy statement were analyzed and fragments from internal organs, their histological preparations
were studied under a microscope, and the necessary areas were photographed and the details were written.
Results of the inspection. In trepanobiopsian material, i.e. bone burial, it became known that,
depending on the degree of development of leukosis, if the mild form of Leukocyte-specific blast cells
were concentrated in a foci-like fashion, while in the heavy form it occupied the entire area of bone burial
and infiltrated diffusely. Most often, hypoplasia of blood clot foci, necrosis, other cells of bone burial are
detected. Thymus. The peculiarity of children's lymphocytic leukosis was that in all cases the thymus
was enlarged to one degree or another, reaching a weight of up to 30 grams in some cases.
Conclusion: Pediatric lymphocytic leukosis is pathomorphologically manifested in all lymphoid
organs with acute-looking leukemic infiltration during the onset of the disease. Depending on whether
lymphocytic leukosis has developed from T or В lymphocytes, it is characteristic of the appearance of
leukemic infiltration in specific areas of the lymphoid organs.
References:
1.
Бурибаева, Б., И. Касимов, and З. Халилова. "Особенности лабораторной характеристики
эшерихиозов у детей." Журнал вестник врача 1.2 (2021): 28-31.
2.
Хайруллина, А. Х. "ВЗАИМОЗАВИСИМОСТЬ УРОВНЯ ЦИТОЛИЗА И ПОКАЗАТЕЛЕЙ
ПРООКСИДАНТНО-АНТИОКСИДАНТНОЙ СИСТЕМЫ, А ТАКЖЕ ЭНДОГЕННОЙ
ИНТОКСИКАЦИ ПРИ ХРОНИЧЕСКОМ ВИРУСНОМ ГЕПАТИТЕ С." ИНФЕКЦИЯ,
ИММУНИТЕТ и ФАРМАКОЛОГИЯ (1999): 229.
