2025
NOVEMBER
NEW RENAISSANCE
INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE
VOLUME 2
|
ISSUE 11
51
OSTEOMYELITIS TREATMENT POSTOPERATIVE PREVENTION
Romanov Jaloliddin Baxodir o'g'li
4th year student of Samarkand State Medical University Faculty of Dentistry
Mamatkulov Farkhodjon Khusenovich
Scientific supervisor,
Faculty of Dentistry, Samarkand State Medical University
https://doi.org/10.5281/zenodo.17526689
Introduction
: Osteomyelitis is a severe inflammatory and infectious disease affecting
bone and bone marrow, commonly caused by bacterial pathogens such as Staphylococcus aureus.
It typically develops from hematogenous spread, direct inoculation during trauma or surgery, or
contiguous spread from adjacent soft tissue infections. Despite advances in surgical techniques
and antimicrobial therapy, osteomyelitis remains a significant clinical challenge due to its chronic
nature, high recurrence rates, and ability of microorganisms to form biofilms on bone surfaces.
These biofilms protect bacteria from host immune mechanisms and reduce antibiotic penetration,
complicating therapeutic outcomes. Delayed diagnosis, antibiotic resistance, impaired vascularity,
and comorbidities such as diabetes mellitus further complicate the prognosis. Considering the
clinical burden and potential complications including sepsis, limb deformities, and bone necrosis,
effective treatment strategies and postoperative preventive measures are essential for long-term
patient recovery and maintenance of musculoskeletal integrity.
Objective
: The objective of this study is to evaluate effective treatment strategies for
osteomyelitis and highlight evidence-based postoperative prevention methods aimed at reducing
recurrence, improving bone healing, and optimizing functional outcomes in affected patients. The
primary objective of this research is to thoroughly examine contemporary therapeutic strategies
for osteomyelitis and to determine the most effective postoperative protocols that minimize
infection persistence, promote optimal bone recovery, and reduce the likelihood of relapse. Special
emphasis is placed on identifying clinical factors that influence treatment success, including
pathogen profile, host immune status, vascular supply, and the timing of medical intervention.
Additionally, the study aims to evaluate the role of biofilm-targeted approaches, local
antimicrobial delivery systems, and integrated rehabilitation programs in maintaining long-term
musculoskeletal function. By synthesizing clinical data and advanced treatment modalities, this
work seeks to provide a comprehensive, clinically applicable framework for managing complex
osteomyelitis cases in modern practice.
Materials and Methods:
This analysis reviewed patients diagnosed with acute and
chronic osteomyelitis at a tertiary medical center. Diagnostic procedures included laboratory tests
(CRP, ESR, leukocyte count), radiological imaging (X-ray, CT, MRI), and microbiological culture
studies obtained through bone biopsy. Treatment modalities assessed included targeted
intravenous and oral antibiotic therapy based on culture sensitivity, surgical debridement of
necrotic tissue, bone stabilization techniques, and use of local antibiotic carriers such as
polymethylmethacrylate beads. Postoperative protocols evaluated consisted of wound care
optimization, glycemic control in diabetic patients, rehabilitation for limb function, and adherence
to scheduled follow-up bone imaging and inflammatory marker monitoring.
Results
: Patients treated with combined surgical debridement and prolonged targeted
antibiotic therapy demonstrated significantly improved infection eradication rates compared to
2025
NOVEMBER
NEW RENAISSANCE
INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE
VOLUME 2
|
ISSUE 11
52
those treated with antibiotics alone. The incorporation of local antibiotic delivery systems showed
enhanced bacterial clearance, especially in chronic osteomyelitis cases. Early aggressive
intervention resulted in better bone regeneration and functional restoration. Recurrence was
minimized in patients adhering to postoperative preventive measures including strict infection
control, nutritional support for immune strengthening, and physiotherapy for restoring limb
mobility and preventing joint stiffness. Poor compliance, inadequate debridement, uncontrolled
diabetes, and delayed treatment initiation were associated with higher recurrence and complication
rates. Clinical evaluation demonstrated that patients receiving a combined approach involving
precisely selected antimicrobial regimens, operative removal of devitalized bone segments, and
the application of localized antibiotic implants exhibited high infection resolution rates and
improved structural bone integrity. Sustained monitoring through inflammatory markers and
imaging revealed progressive decline in inflammatory indicators and increased radiographic
evidence of osteogenesis in compliant individuals. Conversely, late presentation, insufficient
surgical clearance, and systemic conditions such as poor microcirculation or metabolic imbalance
negatively influenced healing dynamics and predisposed patients to persistent low-grade infection
or reinfection episodes. Rehabilitation efforts focusing on controlled load-bearing and progressive
mobility training contributed significantly to functional limb recovery, reduction of contractures,
and prevention of muscle wasting, resulting in restored daily activity performance for the majority
of cases.
Discussion
: Successful osteomyelitis management requires a multimodal approach
integrating accurate diagnosis, microbiologically guided antibiotic therapy, surgical intervention
when necessary, and strict postoperative monitoring. The pathophysiology of osteomyelitis
involves compromised perfusion and biofilm formation, necessitating mechanical removal of
necrotic tissues alongside pharmaceutical therapy. Advances in orthopedic surgical techniques and
biomaterials for local antibiotic delivery have improved outcomes, though emerging antimicrobial
resistance remains a growing concern. Postoperative infection control, patient education, and long-
term surveillance are critical to preventing relapse, as chronic osteomyelitis can persist
asymptomatically before reactivating. Multidisciplinary collaboration among infectious disease
specialists, orthopedic surgeons, and rehabilitation teams plays a decisive role in optimizing
recovery. Management of osteomyelitis remains challenging due to its multifactorial nature and
the dynamic interplay between microbial virulence and host physiological limitations. The success
of therapy hinges not only on eliminating pathogens but also on restoring bone vitality, ensuring
adequate vascularity, and reinforcing host immune mechanisms. Modern therapeutic philosophy
favors aggressive debridement combined with targeted antimicrobial strategies rather than
conservative medical therapy alone. Local antibiotic devices offer a sustained high-dose
antimicrobial microenvironment, particularly effective against biofilm-associated organisms.
Complementary strategies such as optimization of nutritional status, strict control of systemic
diseases including diabetes, and structured postoperative physical therapy create a synergistic
effect that enhances tissue regeneration and reduces mechanical complications. Recurrence often
stems from inadequate follow-up, premature cessation of therapy, and neglect of rehabilitative and
preventive measures, underscoring the importance of multidisciplinary coordination involving
surgeons, infectious disease specialists, physiotherapists, and nursing professionals.
2025
NOVEMBER
NEW RENAISSANCE
INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE
VOLUME 2
|
ISSUE 11
53
Conclusion
: Osteomyelitis treatment demands early diagnosis, appropriate culture-guided
antibiotic therapy, and meticulous surgical debridement to achieve successful infection eradication
and prevent long-term disability. Postoperative prevention strategies, including strict wound care,
metabolic control in comorbid patients, rehabilitation, and scheduled follow-up imaging,
significantly reduce recurrence risk and improve functional outcomes. A coordinated, evidence-
based, and patient-centered approach is essential to achieving durable clinical success and
minimizing complications associated with osteomyelitis. Effective osteomyelitis management
requires a comprehensive and proactive therapeutic approach incorporating early identification,
tailored antimicrobial treatment, surgical precision, and rigorous postoperative care. Sustained
remission and functional recovery are achievable through adherence to evidence-based protocols
that address both infection control and musculoskeletal rebuilding. Establishing strict follow-up
frameworks, providing patient education on wound hygiene and lifestyle modification, and
ensuring consistent physiotherapy engagement are critical to preventing recurrence and preserving
limb functionality. Ultimately, long-term success depends on coordinated clinical oversight,
individualized treatment planning, and persistent monitoring to maintain bone stability, prevent
complications, and improve the overall quality of life for affected individuals.
References
:
1.
Munisovna Х. D. COMPLEX METHODS OF TREATMENT OF CHRONIC
PERIODONTITIS //Conferences. – 2023. – С. 36-40.
2.
Munisovna K. D. et al. GINGIVITIS IN PEOPLE: FEATURES OF DIAGNOSIS,
CLINICAL MANIFESTATIONS AND TREATMENT //ОБРАЗОВАНИЕ НАУКА И
ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ. – 2023. – Т. 20. – №. 3. – С. 58-62.
3.
Xaydarova D., Tilavov X. TREATMENT OF PULP PATHOLOGY IN PATIENTS WITH
CHRONIC PERIODONTITIS //Science and innovation. – 2023. – Т. 2. – №. D12. – С.
79-82.
4.
Хайдарова Д. ПРИМЕНЕНИЕ СОВРЕМЕННЫХ АНТИСЕПТИКОВ ДЛЯ
ПРОФИЛАКТИКЕ В РАЗВИТИЕ ПЕРЕИМПЛАНТИТАХ //Евразийский журнал
медицинских и естественных наук. – 2022. – Т. 2. – №. 6. – С. 62-68.
5.
ВАЛИЕВА, С. Ш., НАБИЕВ, О. Р., ХАЙДАРОВА, Д. М., ГАППАРОВ, Ж. З. У., &
НАСРЕТДИНОВА, М. Т. ВЕСТНИК НАУКИ И ОБРАЗОВАНИЯ. ВЕСТНИК
НАУКИ И ОБРАЗОВАНИЯ Учредители: Олимп, 76-81.
6.
Asrorovna X. N. et al. Anatomy And Topography of The Tooth //Texas Journal of Medical
Science. – 2022. – Т. 4. – С. 1-3.
7.
Xolboeva N., Xaydarova D. BIOLOGICAL METHODS OF TREATMENT OF PULPITIS
//Science and innovation. – 2022. – Т. 1. – №. D8. – С. 73-78.
8.
Asrorovna X. N., Munisovna X. D. COMPLEX METHODS OF TREATMENT OF
CHRONIC PERIODONTITIS //Journal of Integrated Education and Research. – 2023. –
Т. 2. – №. 1. – С. 53-56.
9.
Kholboeva N. A., Khaydarova D. M. MECHANICAL TREATMENT AND EXPANSION
OF ROOT CANALS WITH CHEMICAL PREPARATIONS (ENDOLUBRICANTS)
//Bulletin of Science and Education. – С. 4-1.
2025
NOVEMBER
NEW RENAISSANCE
INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE
VOLUME 2
|
ISSUE 11
54
10.
Munisovna I. R. H. D. et al. TREATMENT OF TEETH DAMAGED BY SURFACE
CARIES IN REM-THERAPY MODE //Galaxy International Interdisciplinary Research
Journal. – 2023. – Т. 11. – №. 11. – С. 513-515.
11.
Холбоева Н. А., Хайдарова Д. М. МЕХАНИЧЕСКАЯ ОБРАБОТКА И
РАСШИРЕНИЕ КОРНЕВЫХ КАНАЛОВ ХИМИЧЕСКИМИ ПРЕПАРАТАМИ
(ЭНДОЛУБРИКАНТЫ) //Вестник науки и образования. – 2022. – №. 4-1 (124). – С.
88-92.
12.
Xolboeva N., Xaydarova D. PROVISION OF THERAPEUTIC DENTAL CARE AND
PREVENTIVE MEASURES DURING PREGNANCY //Science and innovation. – 2022.
– Т. 1. – №. D6. – С. 179-181.
13.
Raxmonova B., Xaydarova D., Sadikova S. TREATMENT OF FRACTURES OF THE
UPPER
AND
LOWER
HEAD
IN
ELDERLY
PATIENTS
USING
THE
IMMOBILIZATION METHOD IMPACT ON PERIODONTAL TISSUE //Science and
innovation. – 2023. – Т. 2. – №. D10. – С. 194-198.
14.
Farrukh S. ORGANIZATION OF DIGITALIZED MEDICINE AND HEALTH
ACADEMY AND ITS SIGNIFICANCE IN MEDICINE //Science and innovation. – 2023.
– Т. 2. – №. Special Issue 8. – С. 493-499.
15.
Валиева С. Ш. и др. Наша тактика лечения больных с болезнью Меньера //Вестник
науки и образования. – 2021. – №. 7-3 (110). – С. 76-81.
16.
Xaydarova D., Karimov I. RESULTS OF THE ASSESSMENT OF CHANGES IN
MASTICATORY MUSCLE TONE IN RELATION TO THE PATIENT'S BODY
POSITION //Science and innovation. – 2023. – Т. 2. – №. D10. – С. 155-157.
