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EFFECTS OF METABOLIC SYNDROME ON UROLOGICAL DISEASES.
Payzieva Ozoda
Fergana State University
1st year doctoral student
Turobiddinova Muntazamkhan
Fergana Institute of Public Health Medicine
Direction of treatment work 1st year student
https://doi.org/10.5281/zenodo.10245258
Abstract.
This article provides information on the impact of Metabolic syndrome on
urological diseases.
Key words:
metabolic syndrome, urolithiasis, div mass index, hypercalciuria,
hyperphosphaturia, hypomagniuria, hyperoxaluria and hyperinsulinemia, urinary stone.
ВЛИЯНИЕ МЕТАБОЛИЧЕСКОГО СИНДРОМА НА УРОЛОГИЧЕСКИЕ
ЗАБОЛЕВАНИЯ.
Аннотация.
В данной статье представлена информация о влиянии
Метаболического синдрома на урологические заболевания.
Ключевые слова:
метаболический синдром, мочекаменная болезнь, индекс массы
тела,
гиперкальциурия,
гиперфосфатурия,
гипомагниурия,
гипероксалурия
и
гиперинсулинемия, мочевые камни.
The growing statistics of urological diseases in our region is a serious concern. In
Uzbekistan, more than 5 thousand out of 100 thousand residents suffer from diseases of the div
system organs every year. This is due not only to the environmental situation in some cities of the
Republic, but also to the way of life of the population, improper nutrition and other factors that
negatively affect human health. Most often, the indicator of pain with the disease is observed in
the Navoi region. It is followed by Khorezm, Samarkand and Jizzakh regions. Uzbekistan today is
one of the leaders in the problem of urinary bladder disease, the urolithiasis recurrence in the
country is more than 45 percent.
In parallel with the increase in metabolic syndrome, the increase in urolithiasis (from 20
to 40% in the population), the prevalence of which has a pandemic scale, is of concern. Currently,
sufficient evidence has been collected to show that urolithiasis is a systemic disease with different
forms of interaction with metabolic syndrome. A number of authors propose to consider
urolithiasis as a renal manifestation of metabolic syndrome, the frequency of its detection reaches
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50% in the presence of all components of metabolic syndrome. The synergistic effect of a number
of metabolic syndrome components leads not only to the appearance of urinary stones, but also to
an increased risk of recurrence after surgical removal, and the pathophysiological mechanisms
underlying them are extremely complex and contradictory. Independent studies provide strong
evidence that increases the risk of developing urolithiasis in people with obesity and metabolic
syndrome.
The purpose of the study.
Determination of the possible relationship of the development
of urolithiasis in overweight and obese metabolically healthy patients by div mass index, urine
pH and mineral composition categories of urolites.
Research results:
our scientific studies have shown these results in patients with kidney-
stone disease.
№
Surname, name Age
Height Weight Body
mass
index (kg/m2)
norm (18.5 -
24.99)
Ratio
between
weight and
length
Urine Ph Stone type
1
Zuhriddinov L
32
172
80
27.04
div weight
excess
5,45
oxalate
stone
2
Yaxyayev U
25
173
79
26.4
div weight
excess
6,35
oxalate
stone
3
Mirzayev A
20
165
83
30.49
first degree
obesity
5,75
oxalate
stone
4
Turiboyeva A
52
167
78
27.94
div weight
excess
6,4
oxalate
stone
5
Shomaxmudova
M
31
165
90
33.06
first degree
obesity
6,11
oxalate
stone
6
Xujakeshov A
43
178
93
29.35
div weight
excess
6,12
oxalate
stone
7
Safarova M
62
165
69
25.34
div weight
excess
6,6
cystine
stone
8
Bahodirov A
33
168
78
27.64
div weight
excess
6.4
oxalate
stone
In our studies, we calculated the div mass index indicator using the formula discovered
by Adolf Ketley.
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Body mass index = div weight (kg / height m2
Body mass index
Body mass index ratio between weight and length of a person
16 and less
Significant deficiency of div weight
16—18,5
Lack of div weight
18,5—24,99
Norm
25—30
Excess div weight
30—35
first degree obesity
35—40
secondary obesity
40 and above
third degree obesity
In order to carry out the task aimed at determining the type of rock formation, a study of
the mineral composition and structural properties of urinary stones was carried out using the X-
ray phase analysis method (spectrometry method), which makes it possible to study the crystal
structure of a small amount of substance in a mixture with other elements.
Conclusion.
An increase in the div mass index is associated with a decrease in the
acidity of the urine and the development of oxalate and phosphate-oxalate urolites. Prevention
and treatment of obesity is a large medical and socio-economic task, the solution of which is not
always successful. Various independent studies have shown that urolithiasis and obesity have
common biochemical mechanisms that can reduce the risk of urinary stones. Lithogenic metabolic
disorders, including increased div mass index, decreased urine volume, hypercalciuria,
hyperphosphaturia, hypomagniuria, hyperoxaluria, and hyperinsulinemia, are the most important
factors associated with obesity and the formation of urinary stones.
