80
STUDYING ITS ANTI-INFLAMMATORY EFFECT AFTER PARENTERAL
ADMINISTRATION OF GLUCOSAMINE SULFATE IN POST-TRAUMATIC
GONARTHROSIS
Mahmaraimov Sh.T.
Senior teacher of the Termiz Branch of the Tashkent Medical Academy
Chariyev M.Yu.
Assistant of the Termiz Branch of the Tashkent Medical Academy
Miraliyev A.M.
Deputy director of the technical school of public health of Sariosiyo named after Abu Ali ibn
Sino, all of Uzbekistan.
https://doi.org/10.5281/zenodo.10325744
Relevance of the topic.
At present, doctors engaged in clinical practice in the conservative
treatment of arthrosis pay great attention to chondroprotectors. The increase in the number of
people who are regularly involved in sports in Uzbekistan has an effect on the increase in the
statistics of post-traumatic knee joint arthrosis (gonarthrosis). At the beginning of the pathogenesis
of arthrosis of the knee joint lies the inflammation and degenerative disorder of the structure of the
joint; parenteral (intramuscular) use of chondroprotector - glucosamine sulfate in order to
eliminate pain, inflammation, and limitation of movement, is showing much better results today.
Glucosamine comes in 2 forms: glucosamine sulfate and glucosamine hydrochloride. Since the
glucosamine hydrochloride molecule is much smaller than the glucosamine sulfate molecule and
its absorption is easy, clinical studies have proven that the therapeutic effect is higher in stabilized
glucosamine sulfate-containing preparations. In our study, glucosamine sulfate (“Sinarta”,
intramuscular injection of 2 ml, in one day No.25) was used as a chondroprotector. Glucosamine
sulfate ("Sinarta") has a significant anti-inflammatory effect on joints; stimulates the synthesis of
type I and II collagens, the amount of which decreases in the skin and tissues with age, improves
phosphorus-calcium exchange in the ankle tissue, the synthesis of proteoglycans and synovial
fluid, as a result, swelling in the joint decreases and vice versa , the amount of synovial fluid
increases and the joint movement becomes easier, pain decreases.
The purpose of the study.
Study of the anti-inflammatory effect of parenteral
(intramuscular) administration of glucosamine sulfate in post-traumatic gonarthrosis in
outpatients.
Research method and material.
A study was conducted on 31 patients with the diagnosis
of gonarthrosis of the I-II-III degree who were being treated on an outpatient basis in
81
multidisciplinary and family polyclinics of the city of Termiz. Age of patients: 20-51, 14 women,
17 men. Patients were prescribed "Sinarta", intramuscular injection of 2 ml, in one day No.25. No
side effects were observed in patients. X-ray and ultrasound examinations of the knee joints were
performed on the Dopler-UZI apparatus.
Research results.
26 out of 31 patients, i.e. 83.8%, who received "Sinarta" intermuscular
injection of 2 ml of in one day No.25, movements in the knee joints reached 80-90% (grade I-II
gonarthrosis) was restored, in the remaining 5 patients (16.2% - grade III gonarthrosis),
movements in the knee joints were restored to 20-30%; it was observed that pain and swelling in
the joint decreased in all patients (this was confirmed by Dopler-UZI ultrasound examination).
Summary.
According to the results of the research, 26 out of 31 patients, i.e., 83.8% (grade
I-II gonarthrosis) who received 2 ml intramuscular injection of "Sinarta" no. 80-90% movement
in knee joints was restored, in the remaining 5 patients (16.2% - III-degree gonarthrosis),
movement in knee joints was restored up to 20-30%; pain and swelling in the joint decreased in
all patients. The reduction of swelling in the joints was also confirmed by the ultrasound
examination on the Doppler-UZI device. By this means, the effective anti-inflammatory effect of
the chondroprotector - glucosamine sulfate when administered parenterally (intramuscularly) in
arthrosis of the knee joint.
