SPONTANEOUS REGRESSION IN MALIGNANT TUMORS

The phenomenon of spontaneous regression of nevi in adolescents is a fascinating and complex process that is not yet fully understood. This natural occurrence, where benign nevi shrink or disappear without any medical intervention, has sparked interest in the fields of dermatology and oncology due to its potential implications for skin cancer prevention, particularly melanoma. This study examines the underlying mechanisms of spontaneous regression, including the role of the immune system, genetic predispositions, and environmental factors, such as sun exposure and hormonal changes during adolescence. It explores the involvement of immune cells, especially T-cells, in identifying and eliminating abnormal melanocytes, as well as the challenges clinicians face in differentiating between regressed nevi and those that may develop into malignancies.