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After the accumulation of copper has begun, this element itself can
disrupt the excretory function of lysosomes, interfering with the synthesis
of tubulin and destroying the microtubules necessary for the movement of
these organelles. In this case, a vicious circle occurs when, under the action
of pyrrolisidine alkaloids, copper exchange at the hepatocyte level is
disrupted leading to the accumulation of an element in the lysosomes in the
metallothionein, which undergoes polymerization and becomes insoluble.
Thus, there is a violation of the synthetic, excretory and depot processes
associated with the exchange of copper, carried out between the subcellular
components of hepatocytes.
In particular, it seems promising for us to include in the diet of animals
from endemic icterohemoglobinuria dysfunctional farms increased doses of
zinc, which has a decreasing effect on copper absorption in the
gastrointestinal tract and also stabilizes cytoplasmic membranes. By the
way, vitamin A also has a similar effect. It is quite possible that these factors
play a role in stopping the outbreaks of ikterohemoglobinuria in the South-
Western Kyzilkum in the spring when grazing sheep on green pastures.
It should be noted that according to our observations, the outbreaks of
this disease of sheep are cyclical in nature and it is correlated with the
amount of rainfall that fell on natural pasture. In those years when the
pasture diet is varied, sheep cover their daily feed requirement without the
consumption of alkaloid plants, the signs of the disease are not noticeable or
absent, and in periods when the diet of animals is poor and the sheep begin
to cover their feed requirement with plants containing alkaloids, outbreak
of the disease.
D. Kakharova,M. Mamadieva, D. Kakharova, Andijan State Medical Institute
EXPREIENCE IN THE TREATMENT OF PURULENT CORNEAL ULCERS WHILE
WEARING SOFT CONTACT LENSES
D. Kakharova,M. Mamadieva, D. Kakharova
Relevance. Purulent corneal ulcer - a serious eye disease, which is the
outcome of gross corneal scarring with persistent depression of vision and,
in extreme cases, loss of an eye as an organ. It proceeds most aggressively
against the background of wearing soft contact lenses.
Purpose. Analysis of the results of treatment of purulent corneal ulcers
on the background of wearing soft contact lenses.
Material and methods. Under observation were 11 patients (11 eyes)
with a diagnosis of purulent corneal ulcer on the background of soft contact
Scientific research results in pandemic conditions (COVID-19)
117
lenses. Patients were admitted on the background of antibacterial
treatment, on average, on the 7th day from the onset of the disease (in 3
cases on the 20th day). Visometry, biomicroscopy, ophthalmoscopy, and
bacteriological examination of the corneal surface were performed.
Results.We managed to achieve stable remission in two patients (they
took ophtax, tobradex, phloximed). Against the background of powerful
conservative treatment in 9 people, the disease had a continuously recurring
course with short periods of remission. Subsequent exacerbations were
more severe, with multiple complications: perforation of the cornea,
secondary hypertension, complicated cataract; in 2 patients - with lysis of
the lens and prolapse of the membranes of the eye. Due to the ineffectiveness
of conservative treatment, keratoplasty surgery was advised to nine
patients. In 2 patients, cataract extraction was additionally performed. In the
long-term period, 7 patients had visual acuity of 0.3-0.4. In 2, an eye
enucleation operation was performed.
Conclusions. A continuously recurring course and subsequent serious
complications require the development of special tactics for treating
patients with purulent corneal ulcers while wearing soft contact lenses.
Most patients were advised to have keratoplasty surgery.
D. Kakharova,M. Mamadieva, D. Kakharova, Andijan State Medical Institute
COMPLEX TREATMENT OF COMPUTER VISUAL SYNDROME IN
SCHOOLCHILDREN
D. Kakharova,M. Mamadieva, D. Kakharova
Relevance. General computerization of recent years has brought new
challenges. One of them is computer visual syndrome (GLC).
Purpose. The purpose of our study was to study the various
manifestations of CVD in adolescent children and to develop a protocol for
prevention and treatment.
Materials and Methods. Under our dynamic supervision, there were 60
patients aged 12-14 years who spend more than 4 hours behind monitor
screens. All patients underwent standard ophthalmologic examination,
including
visometry,
skioscopy,
biomicroscopy,
ophthalmoscopy,
autorefractometry. Also consider complaints of patients surveyed reserve
accommodation, a study of the tear film stability
Results. After analyzing the data from the above studies, we found that
2/3 of children (39 people) complained of visual fatigue in the evening, pain
and dryness in the eyes, their redness. Signs of instability of the tear film
