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ASSESSMENT OF INDICATORS OF CYTOPENIC SYNDROME IN
PATIENTS DIAGNOSED WITH LIVER CIRRHOSIS OF VIRUS
ETIOLOGY
Kurbonova Z.Ch.
Anvarov J.A.
Shodiyeva G.E.
Adilov A.A.
Sherkulov B.B.
Tashkent Medical Academy, Tashkent
https://doi.org/10.5281/zenodo.13907087
Significance.
In the world, special attention is being paid to scientific
research aimed at identifying changes in the general blood analysis in liver
cirrhosis of viral etiology, as well as the characteristics of cytopenic syndrome
and improving measures to develop these changes. In this regard, the study of
the etiological factors of liver cirrhosis, that is, the study of the molecular genetic
characteristics of the hepatitis B virus (HBV) and hepatitis C virus (HCV), the
identification of the pathogenetic development of the disease in patients with
liver cirrhosis, the assessment of the level of features of cytopenic syndrome in
these patients and their study of various stages of liver diseases and their
relationship with etiology, early diagnosis of these changes and improvement of
treatment requires implementation of a number of tasks, and conducting
research in this direction is of particular importance.
The purpose of the study
. Assessment of indicators of cytopenic
syndrome during general blood analysis in patients diagnosed with liver
cirrhosis of viral etiology.
Research material and methods
. Scientific research work was carried out in
2023-2024 at the clinical base of the Tashkent Medical Academy and the
Republican Specialized Scientific-Practical Medical Center of Epidemiology,
Microbiology and Infectious Diseases (RSSPMCEMID). To carry out scientific
research, patients were observed in the department of hepatology of the TMA
clinic and the department of chronic viral hepatitis of RSSPMCEMID. A total of 60
patients with liver cirrhosis (B, C, D) of viral etiology were studied in the study.
In the study group 45% of the patients were women and 55% were men. If we
divide the patients by age, 31.6% of patients aged 20 to 40, 35% of patients aged
41 to 55, 56 to 75 and patients under the age of 33.4%. The tactics of clinical and
laboratory examination, diagnosis and treatment of patients were carried out on
the basis of the "Protocol on diagnosis and treatment of infectious diseases" of
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the Ministry of Health of the Republic of Uzbekistan and Order 542 of the
Ministry of Health of the Republic of Uzbekistan.
When laboratory tests were performed on patients, general blood analysis was
taken from all patients from the first day of arrival to the hospital. These
analyzes were checked in the hospital laboratory by conventional methods.
Results.
According to the results of the research, the general blood analysis of
60 patients with viral hepatitis was studied. As a result, the decrease in blood
cells was clearly evident: the erythrocyte index was found to be decreased in 24
(40%) of 60 patients, increased in 8 (13.3%) patients, and normal in 28 (46.7%)
patients. The number of leukocytes decreased in 37 (61.7%) of 60 patients,
increased in 5 (8.3%) patients, and remained unchanged in 18 (30%) patients. It
was found that the thrombocyte index decreased sharply in 34 (56.6%) patients,
and significantly increased in 3 (5.0%) patients. It was found that the amount of
hemoglobin decreased in 29 (48.3%) patients, but the amount of hemoglobin
was normal in 31 (51.6%) patients. ESR indicator in the general blood analysis
was within the normal range in 33 (55.0%) patients, and in the remaining 27
(45%) patients, ESR was increased, and in these patients, new type of anemia,
leukopenia and thrombocytopenia were clearly demonstrated.
Conclusions
. A low level of hemoglobin in peripheral blood and low levels of
blood cells (erythrocytes, leukocytes, platelets), an increase in ESR in most
patients, as well as leukopenia and thrombocytopenia observed in all examined
individuals indicate the presence of cytopenic syndrome in patients with liver
cirrhosis of viral etiology.
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