T A D Q I Q O T L A R
jahon ilmiy – metodik jurnali
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ISSN:3030-3613
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SIRKA KISLOTASI TOKSIK TA’SIRIDA YUZAGA KELGAN JIGAR
SHIKASTLANISHIDA SILYBUM MARIANUM YOG‘INING
BIOKIMYOVIY SAMARASI
Allayeva A.N.
Buxoro Davlat Tibbiyot Instituti
Anatomiya va klinik anatomiya(OXTA)
kafedra assistenti
https://orcid.org/0009-0004-2661-5078
Annotatsiya:
Mazkur maqolada sichqonlarda sirkaviy moddalar yordamida
chaqirilgan subakut metabolik buzilishlar va ularga sutgiyohi yog‘i (Silybum
marianum (L.) Gaertn) bilan tuzatish imkoniyati eksperimental jihatdan o‘rganilgan.
Terapevtik samaradorlik qonning klinik-biokimyoviy ko‘rsatkichlari – transaminazalar
(ALT, AST), kreatinin, umumiy oqsil, umumiy xolesterin, glyukoza va triglitseridlar
miqdoridagi o‘zgarishlar orqali baholangan.
Kalit so‘zlar:
dori o‘simlik xomashyosi, sutgiyohi yog‘i, Silybum marianum
(L.) Gaertn, gepatoprotektor, biologik tajriba, klinik-biokimyoviy tahlillar.
Kirish:
Zararlı va xavfli ishlab chiqarish omillariga bog‘liq kasalliklarda yuzaga
keluvchi metabolik buzilishlarni to‘g‘rilash muammosi bugungi kunda dolzarbdir.
Dori vositalari doimo yetarli natija bermaydi, ko‘p hollarda ko‘plab dorilar birgalikda
qo‘llanilib, bu esa nojo‘ya ta’sirlar xavfini oshiradi. Shu sababli, tabiiy davolash
omillari – ayniqsa o‘simlik asosidagi preparatlar – metabolizmga ijobiy ta’sir
ko‘rsatish xususiyatiga ega bo‘lib, ularning sintetik muqobillariga nisbatan
xavfsizroqdir. Gepatoprotektiv xususiyatga ega dorilar – legalon, silibor, karsil,
gepabene – ko‘p hollarda Silybum marianum mevalaridan tayyorlanadi.
Tadqiqotning maqsadi:
Sichqonlarda sirkaviy kislota yordamida chaqirilgan
jigarning subakut toksik shikastlanishi fonida yuzaga keladigan metabolik
o‘zgarishlarni aniqlash va ularni sutgiyohi yog‘i yordamida tuzatish imkoniyatlarini
baholash.
Material va usullar:
Tajriba uchun 180-240 g og‘irlikdagi Wistar zichqonlari
uchta guruhga ajratildi. 46% sirka eritmasi orqali jigarning toksik shikastlanishi
modellandi. Shundan so‘ng 5 kun davomida kuniga 3 mahal 0,2 ml dozada sutgiyohi
yog‘i berildi. Biokimyoviy ko‘rsatkichlar tahlil qilinganda, sutgiyohi yog‘i
yallig‘lanish belgilarini kamaytirgani, transaminazalar (AST, ALT) darajasini
tiklagani,
lipid-glukoz
metabolizmini
va
gepatozellulyar
funksiyalarni
normallashtirgani qayd etildi.
T A D Q I Q O T L A R
jahon ilmiy – metodik jurnali
https://scientific-jl.com
63-son_3-to’plam_Iyun-2025
311
ISSN:3030-3613
Xulosa:
Sutgiyohi yog‘i bilan 5 kunlik davolash kursi sirkaviy intoksikatsiya
fonida jigarda rivojlangan metabolik buzilishlarni sezilarli darajada bartaraf etadi.
Ushbu yog‘ tarkibidagi bioaktiv moddalarning kompleksi jigarning glyukoneogenez,
lipotropik, detoksikatsion va immunomodulyator funksiyalarini faollashtiradi.
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