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63-son_1-to’plam_Iyun-2025
383
ISSN:3030-3613
COMPARATIVE DESCRIPTION OF THE MORPHOLOGICAL
INDICATORS OF THE GESTINAL GLAND IN LIVER INJURY UNDER
EXPERIMENTAL CONDITIONS
Ruziyeva Dilbar Uktamovna
Zarmed University Department of Clinical Sciences
Annotation
: Infertility is a disease that affects millions of men of reproductive
age worldwide today, and its negative impact on families and society makes this
pathology an urgent global medical and social problem. Male infertility can be caused
directly or indirectly by many diseases and factors. Liver damage negatively affects
the morphofunctional parameters of the testicles.
Keywords
: infertility, liver, hepatobiliary system, germ cells, rats.
Relevance
: In fact, male infertility is not a nosological form. It is a
pathological process that can be caused directly or indirectly by many diseases
and factors that are very diverse in nature. In their studies, S. Karamolahi et al.
evaluated the effect of viral hepatitis B and C (HBV and HCV) on the quality of
male sperm and concluded that these diseases negatively affect such parameters
as concentration, motility and morphology. [Сизоненко М.Л., 2015]. Literature
data show that chronic liver damage of various genesis in female rats leads to
the development of non-specific changes in the morphofunctional structure of
the interstitial space of the testicles of their offspring, which is reflected in
changes in the volume of interstitial tissue, the total number of endocrinocytes
and their various morphofunctional types, as well as the concentration of
hormones produced by them. Damage to the hepatobiliary system of female rats
causes changes in the microenvironment of developing male germ cells, which
is manifested in a decrease in the number of CD68+ cells in the testicular
interstitial connective tissue of experimental animals [Babanin A. A., Ul anov V.
S., 2014; Masluakova G. N., 2016].
One of the links in the pathogenesis of impaired formation of the generative
department of the male gonad is the activation of the apoptosis process of male
germ cells, which is confirmed by an increase in the number of active cells
(CPP32) and a decrease in the number of Bcl-2+ in the spermatogenic layer of
experimental animals. The pathology of the hepatobiliary system of female rats
is accompanied by the development of oxidative stress in the testicular tissues
of their offspring, which is manifested in changes in the oxidation indices in the
heptane and isopropanol phases in the homogenates of the testicles of
experimental animals [Пауков В. С., Ерохин Ю. А., 2020]. Experimental
modeling of chronic pathology of the hepatobiliary system in female rats is
T A D Q I Q O T L A R
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384
ISSN:3030-3613
accompanied by changes in the cytokine profile in the blood serum of their
offspring, which is manifested in changes in the levels of anti -inflammatory
cytokines IL-β, IL-2, IL-8 and TNF [Bilalov B.E., 2024]. Numerous fundamental
studies devoted to the problem of the complex effect of exogenous and
endogenous influences on the human div have proven their depressive effect
on the regulatory systems of the organism. At the same time, the study of
morphological indicators of the testis in the liver damage of the testis in
experimental conditions of testicular tissue, which is sensitive to disturbances in
homeostasis, remains relevant for researchers.
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