This article discusses patients with serorresis syphilis obtained as an additional - tion treatment by the following procedures: I - group (33.9%) were treated with penicillin for 1 Mill. U every 6 hours to a total dose - 120 million units;. Group II (26.3%) received treatment with ceftriaxone 1.0 intramuscularly 1 time per day for 16 days (amount - 16.0); Group III (39.8%) with ceftriaxone 1.0 daily for 16 days (16.0). In venereology, the problem of syphilitic seroresistance is of great importance. In addition, the study of the causal factors in the development of seroresis in syphilis is an important direction in science.