During embryonic histogenesis of human lungs, early morpho- functional differentiation of apudocytes is observed. In the lungs of young children with an inflammatory pathology of this organ, endocrine structures are detected with great constancy, and their number is large. The longer the disease lasts, the more apudocytes and NETs are found in the bronchi and respiratory tract. In large bronchi there are more endocrine structures than in small ones. Inflammatory lung diseases in early postnatal ontogenesis are a predisposing factor for apudocyte hyperplasia.
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