Ta'limda raqamli texnologiyalarni tadbiq etishning zamonaviy tendensiyalari va rivojlanish omillari
45-to’plam_1-qism_Iyul-2025
261
CARBOHYDRATE METABOLISM AND IMMUNE-INFLAMMATORY
INTERACTIONS IN DELAYED FRACTURE HEALING AFTER COVID-19
Badriddinov Akobir Sadriddinovich
Khamdamov Bakhtiyor Zaripovich
Bukhara State Medical Institute
Annotation
Metabolic disorders such as insulin resistance and hyperglycemia
have become increasingly common in post-COVID patients. These alterations are
known to influence immune function and inflammation, both of which are critical in
bone tissue repair. Analyzing how carbohydrate metabolism affects immune markers
can improve diagnostic and therapeutic approaches for delayed consolidation. This
article provides scientific research information about carbohydrate metabolism and
immune-inflammatory interactions in delayed fracture healing after COVID-19.
Keywords:
bone healing, Post-COVID-19, patients, bone fractures.
Relevance:
The interactions between diabetes mellitus, obesity, and SARS-CoV-
2 infection are complex, involving metabolic dysregulation, chronic inflammation, and
impaired immune response. Diabetes mellitus and obesity, known to impair immune
function, have been identified as risk factors for severe outcomes of SARS-CoV-2
infection. These conditions are characterized by metabolic dysregulation and chronic
inflammation, which may exacerbate the severity of SARS-CoV-2 infection.
Understanding these interactions is important for the management of SARS-CoV-2
patients during and after active infection in these high-risk groups.
Purpose of the study:
To evaluate the relationships between carbohydrate
metabolism indicators and immune-inflammatory markers in patients with impaired
fracture healing post-COVID-19.
Materials and Methods:
The study involved 126 post-COVID patients with
delayed long bone fracture healing. Glucose, insulin, HOMA-IR, and glycated
hemoglobin were analyzed alongside immunoglobulins, cytokines, CRP, lactoferrin,
and INF-γ. Correlations were calculated using Pearson/Spearman methods (P < 0.05).
Research Results:
Glucose, insulin, and HOMA-IR showed strong positive
correlations with IgA, IgG, IgM, IgE, CRP, and IL-1β/IL-6, indicating systemic
immune activation. Lactoferrin was negatively correlated with glucose and insulin,
reflecting impaired innate immunity. INF-γ levels inversely correlated with
carbohydrate markers, suggesting compromised antiviral defense. IL-6, a key
proinflammatory cytokine, strongly correlated with insulin resistance. These findings
support the role of hyperglycemia and immune dysregulation in delayed bone healing.
Ta'limda raqamli texnologiyalarni tadbiq etishning zamonaviy tendensiyalari va rivojlanish omillari
45-to’plam_1-qism_Iyul-2025
262
Conclusion:
Carbohydrate metabolism disturbances contribute to chronic
inflammation and immune dysfunction, which underlie delayed fracture consolidation
in post-COVID patients. Controlling glycemic parameters may improve bone healing
outcomes.
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