Ta'limda raqamli texnologiyalarni tadbiq etishning zamonaviy tendensiyalari va rivojlanish omillari
45-to’plam_1-qism_Iyul-2025
259
CORRELATION BETWEEN LIPID PROFILE AND
IMMUNOLOGICAL MARKERS IN POST-COVID PATIENTS
WITH DELAYED FRACTURE HEALING
Badriddinov Akobir Sadriddinovich
Khamdamov Bakhtiyor Zaripovich
Bukhara State Medical Institute
Annotation
The treatment of traumatic injuries with delayed bone consolidation
remains a pressing issue due to its severe functional and social consequences. The
COVID-19 pandemic has intensified systemic immune and metabolic disturbances that
impair osteogenesis. Understanding how lipid disorders correlate with inflammatory
and immune markers is crucial for developing targeted therapies. This article provides
scientific research information about correlation between lipid profile and
immunological markers in post-COVID patients with delayed fracture healing.
Keywords:
bone healing, Post-COVID-19, patients, bone fractures.
Relevance:
T helper 17 cells (Th17 cells), a subset of CD4+ T cells, are key in
bone homeostasis and immune responses during SARS-CoV-2 infection. Th17 cells
produce IL-17, a stimulator of osteoclastogenesis, and express RANKL, a key mediator
of bone homeostasis. During SARS-CoV-2 infection, Th17 cells contribute to the
pathogenesis of the cytokine storm, which is known to promote bone loss. Elevated IL-
17 levels are observed in mild cases of COVID-19, further implicating the role of Th17
cells in the disruption of bone homeostasis. An imbalance between Th17 and regulatory
T cells is known to contribute to bone-related diseases, providing another mechanism
by which SARS-CoV-2 infection may impact bone.
Purpose of the study:
To assess the correlation between lipid metabolism
parameters and immunological indicators of inflammation in patients with delayed
fracture healing after COVID-19.
Materials and Methods:
The study included 126 patients with post-COVID long
bone fractures. Lipid markers (TC, LDL, HDL) and immune-inflammatory parameters
(IgA, IgG, IgE, CRP, IL-1β, IL-4, IL-6, lactoferrin, INF-γ) were evaluated by
VektorBest. Correlation coefficients were calculated using Pearson or Spearman
methods; significance was set at P < 0.05.
Research Results:
Elevated total cholesterol and LDL showed moderate positive
correlations with IgA, IgG, IgE, CRP, IL-1β, IL-4, and IL-6 levels. Negative
correlations were observed between LDL/TC and lactoferrin and INF-γ, indicating
suppression of osteogenic and antiviral responses. HDL demonstrated inverse
correlations with pro-inflammatory markers, reflecting its protective role.
Ta'limda raqamli texnologiyalarni tadbiq etishning zamonaviy tendensiyalari va rivojlanish omillari
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260
Dyslipidemia was associated with chronic inflammation and immune dysregulation.
These changes likely impair bone regeneration and promote prolonged consolidation
delays.
Conclusion:
Dyslipidemia contributes to immune imbalance and inflammatory
activation, leading to impaired fracture healing in post-COVID patients. Monitoring
lipid profiles may aid in predicting and managing delayed bone regeneration.
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