Ta'limda raqamli texnologiyalarni tadbiq etishning zamonaviy tendensiyalari va rivojlanish omillari
45-to’plam_1-qism_Iyul-2025
263
POST-COVID-19 IMPAIRMENTS OF BONE METABOLISM
IN PATIENTS WITH LONG BONE FRACTURES
Badriddinov Akobir Sadriddinovich
Khamdamov Bakhtiyor Zaripovich
Bukhara State Medical Institute
Annotation
Vitamin D plays a central role in calcium homeostasis and bone
matrix mineralization. Post-COVID-19 patients often develop vitamin D deficiency,
which may impair bone healing. Understanding the biochemical changes in such
patients is essential for optimizing fracture management. This article provides
scientific research information about post-COVID-19 impairments of bone metabolism
in patients with long bone fractures.
Keywords:
bone healing, Post-COVID-19, patients, bone fractures.
Relevance:
Patients with SARS-CoV-2 often have nutritional problems,
including malnutrition and significant weight loss, which may impact bone health.
Vitamin D3, or cholecalciferol, is associated with the regulation of bone, calcium, and
phosphorus metabolism, as well as the modulation of the immune system. Its
deficiency can lead to immune dysregulation, including impaired macrophage function
and increased production of proinflammatory cytokines, which indirectly impacts bone
health.
Aim of the Study:
To evaluate biochemical markers of bone metabolism in post-
COVID-19 patients with long bone fractures and to assess their correlation with
fracture healing outcomes.
Materials and Methods:
A total of 126 patients with long bone fractures who
had recovered from COVID-19 at least 6 months earlier were included. They were
stratified by age, sex, fracture type, and bone healing characteristics. Serum levels of
25(OH)D, osteocalcin, and β-CrossLaps were measured upon hospital admission.
Fracture consolidation was monitored and categorized into normal, delayed, and
complicated healing groups.
Results:
The highest incidence of fractures was among males aged 18–44. Most
fractures were simple and involved the femur. Patients with delayed and complicated
healing had significantly lower levels of 25(OH)D and osteocalcin. In contrast, β-
CrossLaps levels were elevated in these groups, indicating enhanced bone resorption.
There was a clear imbalance between bone formation and resorption in patients with
delayed consolidation.
Ta'limda raqamli texnologiyalarni tadbiq etishning zamonaviy tendensiyalari va rivojlanish omillari
45-to’plam_1-qism_Iyul-2025
264
Conclusions:
Post-COVID-19 metabolic alterations negatively affect bone
healing. Monitoring and correcting vitamin D deficiency may improve fracture
outcomes in these patients.
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