DOI:
https://doi.org/10.71337/inlibrary.uz.universaljurnal.111181Kalit so‘zlar:
aorta silliq tolali muskul hujayralari tunica media Ca²⁺ kalmudulin MLCK RhoA ROCK PKC CPI-17Annotasiya
Aorta silliq tolali muskul hujayralari (STMHU) aorta devorining tunica media
qavatini tashkil etib, arterial moslashuvchanlik va qon bosimini barqaror saqlashda markaziy rol
o‘ynaydi. Ularning qisqarishi hujayra ichidagi Ca²⁺ signallari, kalsiy–kalmudulin kompleksi orqali
myozin yengil zanjir kinazani (MLCK) faollashtirish, shuningdek RhoA/ROCK va PKC/CPI-17
yo‘llari orqali kuchaytiriladi, natijada aktin–miozin kesishmalari hosil bo‘lib, devor tarangligi
oshadi. Bo‘shashish esa endoteliy hujayralaridan sintezlangan azot oksidi (NO) orqali cGMP/PKG
hamda β₂-adrenoseptor–cAMP/PKA yo‘llarini ishga solishi natijasida Ca²⁺ konsentratsiyasi
pasayishi va myozin yengil zanjir fosfataza (MLCP) faollashuvi orqali yuzaga keladi.
Bibliografik manbalar
Aorta. Wikipedia. https://en.wikipedia.org/wiki/Aorta
Tunica media. Wikipedia. https://en.wikipedia.org/wiki/Tunica_media
Smooth muscle. Wikipedia. https://en.wikipedia.org/wiki/Smooth_muscle
Mechanisms of Vascular Smooth Muscle Contraction and the Basis of Relaxation. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC4819215/
RhoA/Rho-Kinase: Pathophysiological and Therapeutic Implications. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC5599165/
Complex interactions of NO/cGMP/PKG systems on Ca2+ signaling. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC2806127/
Vascular Smooth Muscle Cell Signaling Mechanisms for Contraction and Relaxation. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC2704475/
