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MALE INFERTILITY THERAPY: ANALYSIS OF STUDIES
Turdiyev Doston Shavkatovich
Bukhara Innovative Education
and Medical University.
assistant of the Department
of clinical and pre-clinical sciences
Аnnotation.
AndroDoz has shown promising clinical efficacy in the
treatment of male infertility. Its antioxidant components have been associated with
improved semen quality, including increased sperm concentration, motility, and
normal morphology. Clinical studies also report reduced sperm DNA
fragmentation and higher pregnancy rates, both via assisted reproductive
technologies and natural conception. The absence of adverse effects supports its
safety and potential for widespread use in patients with pathozoospermia and
idiopathic infertility.
Keywords:
male infertility, idiopathic infertility, pathozoospermia,
antioxidant therapy, AndroDoz
Infertility
is a relevant and socially significant issue faced by approximately
15% of married couples. According to WHO data, at the beginning of the current
century, abnormal ejaculate parameters were found in about half of men in
infertile marriages . Observations in recent years have revealed a consistent trend
of a gradual decline in sperm count among men in developed countries from 1973
to 2011. Despite the continuous improvement of diagnostic methods, the causes of
male fertility decline remain unidentified in many cases, and in 40-60% of cases,
male infertility is classified as idiopathic [1].
According to current understanding, the decline in reproductive function in
many men with idiopathic infertility may be due to the pathological effects of
reactive oxygen species (ROS) on spermatozoa. Under normal conditions, ROS
are continuously generated during cellular metabolism, and their presence within
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physiological levels supports hyperactivation, the acrosomal reaction, and
capacitation of spermatozoa, which are necessary for successful conception.
However, under normal conditions, an excess of ROS can be inactivated by the
antioxidant system. If their production exceeds the protective capacity of the cell,
it can lead to oxidative stress — severe damage to lipids, proteins, cellular
membranes, and DNA molecules in spermatozoa. This causes impaired sperm
motility and interaction with the oocyte and may lead to errors in the union of
genetic material from the father and mother, abnormal embryo development, and
early pregnancy loss [2].
Currently, various lifestyle, environmental, and physiological factors have
been identified that contribute to the activation of molecular-cellular mechanisms
of oxidative stress and the development of infertility in men: smoking, alcohol
abuse, exposure to herbicides, fungicides, petroleum distillation products,
radioactive radiation, varicocele, obesity, diabetes, stress, inflammatory diseases
of the reproductive organs, increased temperature, and others [3].
At the same time, it has been proven that there are antioxidants — vitamins,
minerals, amino acids, and other organic compounds — which, by enhancing
metabolic processes, activating nuclear-cytoplasmic transport, reducing
inflammation, and weakening autoimmune reactions, can reduce oxidative stress.
[4] . The intake of preparations containing these substances in infertile men leads
to improved sperm parameters, restoration of sperm function, and an increase in
pregnancy rates, including when using assisted reproductive technologies (ART) .
Despite the large number of publications dedicated to studying the effect of
antioxidants on male fertility, insufficient data have been accumulated to provide
high-confidence evidence-based recommendations regarding the dosage,
frequency, and duration of each antioxidant's use [5]. Since there is a wide range
of available preparations containing multiple antioxidants in different dosages for
clinical use, their advantages can only be assessed based on the results of
conducted clinical studies.
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AndroDoz
contains L-arginine, L-carnitine, L-carnosine, coenzyme Q10,
glycyrrhizic acid, zinc, vitamin E, vitamin A, and selenium in doses that, with the
recommended regimen of 4 capsules per day, can provide 12-80% of the daily
recommended intake [6]. The positive impact of the components in the AndroDoz
complex on male fertility has been confirmed by many specialists. According to
the results of placebo-controlled studies, the intake of L-carnitine contributed to
an increase in sperm concentration and motility in men [7]. Zinc and selenium
play an important role in regulating the hormone-producing function of the testes
and maintaining adequate levels of testicular testosterone, as well as stabilizing
chromatin, ensuring oxygen consumption by spermatozoa, and capacitation. The
protective effect of zinc, preventing a decrease in sperm motility and DNA
fragmentation, was described by R. Talevi et al., noting that it is primarily
observed in men with oligozoospermia [8].
Conclusion.
The article discusses male infertility, emphasizing the role of
oxidative stress and antioxidants in improving fertility. It highlights how factors
like lifestyle and environment contribute to oxidative damage, and how
antioxidants (e.g., vitamins, minerals, amino acids) can improve sperm quality.
AndroDoz, a biocomplex containing key antioxidants, has shown effectiveness in
enhancing sperm concentration, motility, and overall fertility. However, further
research is needed to establish optimal treatment guidelines.
REFERENCES
1. Agarwal A., Mulgund A., Hamada A., Chyatte M.R. A unique view on
male infertility around the globe. Reprod Biol Endocrinol. 2015;13:37. doi:
10.1186/s12958-015-0032-1.
2. Agarwal A., Mulgund A., Hamada A., Chyatte M.R. A unique view on
male infertility around the globe. Reproductive Biology and Endocrinology.
2015;(13):37. Available at: https:// rbej.biomedcentral.com/articles/10.1186/
s12958-015-0032-1.
3. Levine H., Jørgensen N., Martino-Andrade A., Mendiola J., Weksler-Derri
D., Mindlis I., Pinotti R., Swan S.H. Temporal trends in sperm count: a systematic
review and meta-regression analysis. Hum Reprod Update. 2017;23(6):646-659.
doi: 10.1093/humupd/dmx022.
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4. Nieschlag E., Behre H.M., Nieschlag S. (Ed.). Andrology: Male
Reproductive Health and Disfunction. 3rd. 2010;(629). doi: 10.1007/978- 3-540-
78355-8.
5. Punab M., Poolamets O., Paju P., Vihljajev V., Pomm K., Ladva
R., Korrovits P., Laan M. Causes of male infertility: a 9-year prospective
monocentre study on 1737 patients with reduced total sperm counts. Hum Reprod.
2017;32(1):18-31. doi: 10.1093/humrep/ dew284.
6. Kamkar N., Ramezanali F., Sabbaghian M. The relationship between
sperm DNA fragmentation, free radicals and antioxidant capacity with idiopathic
repeated pregnancy loss. Reprod Biol. 2018;18(4):330-335. doi: 10.1016/j.
repbio.2018.11.002.
