Comparative evaluation of anesthetics and their use in the rural population

CC BY f
94-96
0
0
Поделиться
Мукимов O., & Исанова D. (2019). Comparative evaluation of anesthetics and their use in the rural population. in Library, 19(2), 94–96. извлечено от https://inlibrary.uz/index.php/archive/article/view/14800
Одилжон Мукимов, Ташкентский государственный стоматологический институт

ассистент кафедры оперативной стоматологии и дентальной имплантологии

Диёра Исанова, Ташкентский государственный стоматологический институт

студентка 4 курса

0
Цитаты
Crossref
Сrossref
Scopus
Scopus

Аннотация

The success of modern dentistry is largely due to the development and implementation in practice of new tools and methods that allow painlessly carry out long and large – scale interventions in the oral cavity. The most effective and safe way of anesthesia on an out-patient dental reception is local anesthesia. For the time being. The most effective of them are recognized drugs created on the basis of articaine, due to the peculiarities of its phar-macokinetics  and  pharmacodynamics.  The  articaine  containing  products  produced  by various foreign companies and is known for its proprietary trade names: al-fakin (Dens-ply,  France),  Articaine  of  INIBSA  (Inibsa,  Spain),  Prilocain  (Russia),  Primaquin (France), Septanest  (Septodont,  France),  Ubistesin  (ZM  ESPE,  Germany),  Ultracain (Sanofi-Aventis, Germany), Cytokeratin (Italy). The main component of all these drugs is a local anesthetic – articaine, which determines, on the one hand, the General features of the action of all these drugs, and on the other-their distinctive features in comparison with drugs created on  the  basis  of  lidocaine or mepivacaine. Articaine, lidocaine and mepivacaine are international nonproprietary names (INN), which are indicated along with trade names (E. V. Zoryan, S. A. Rabinovich)


background image

94

MONOGRAFIA POKONFERENCYJNA

Introduction

: local anesthetics are

substances that, when interacting with

nerve fibers and their endings, can revers-

ibly inhibit the formation and conduction

of nerve impulses on them. The effect of

local anesthesia depends not only on the

properties and concentration of the drug,

but also on the thickness of the myelin

sheath of the nerve fiber that prevents the

penetration of the anesthetic through the

cell membrane. Search and improvement

of methods of local anesthesia is one of

the most important tasks of modern den-

tistry. The main task of local anesthesia is

to achieve anesthesia of the necessary tis-

sue area, and all other effects of its action

are considered as side effects. To do this,

we need to know the objective assessment

of the anesthetic.

The aim of our study was

: to Study the

features-actions* of modern domestic ar-

ticaine-containing anesthetic «Supercain»

to improve the efficiency and safety of lo-

cal anesthesia by introducing into dental

practice. Experimentally and clinically jus-

tify the advantages and disadvantages of

anesthetics. Find the optimal use of local

anesthetics in the rural population.

COMPARATIVE EVALUATION OF ANESTHETICS AND THEIR

USE IN THE RURAL POPULATION

Mukimov Odiljon Ahmadjonovich

(assistant of Department of operative dentistry and dental implantology,

the Tashkent State Dental Institute.),

Isanova Diyora-Rovshanbekovna

(4th year student of the Tashkent State Dental Institute )

ABSTRACT:

The success of modern dentistry is largely due to the development and implementation

in practice of new tools and methods that allow painlessly carry out long and large – scale

interventions in the oral cavity. The most effective and safe way of anesthesia on an out-

patient dental reception is local anesthesia. For the time being. The most effective of them

are recognized drugs created on the basis of articaine, due to the peculiarities of its phar-

macokinetics and pharmacodynamics. The articaine containing products produced by

various foreign companies and is known for its proprietary trade names: al-fakin (Dens-

ply, France), Articaine of INIBSA (Inibsa, Spain), Prilocain (Russia), Primaquin

(France), Septanest (Septodont, France), Ubistesin (ZM ESPE, Germany), Ultracain

(Sanofi-Aventis, Germany), Cytokeratin (Italy). The main component of all these drugs

is a local anesthetic – articaine, which determines, on the one hand, the General features

of the action of all these drugs, and on the other-their distinctive features in comparison

with drugs created on the basis of lidocaine or mepivacaine. Articaine, lidocaine and

mepivacaine are international nonproprietary names (INN), which are indicated along

with trade names (E. V. Zoryan, S. A. Rabinovich)

Key words:

anesthetics, rural population, articaine


background image

95

SCIENCE, RESEARCH, DEVELOPMENT

№17

Materials and methods of research:

1.Clinical examination of patients.

2.Statistical methods of processing the

results of the study.

3. Laboratory research methods.

For the study were taking 30 patients,

which we divided into 3 groups. In group

I the anesthetic Articaine was used. In the

second group used the drug superchain

Forte. In group III, was used in the prepa-

ration supercam.all these drugs are ge-

neric drug Ubistesin. Ubistesin combined

preparation for local anesthesia in den-

tistry. Part of it, the articaine is a local

anesthetic of the amide type titanovoe

group. Due to the low content of epineph-

rine in the drug, its effect on the cardio-

vascular system is expressed little: there is

almost no increase in blood pressure and

an increase in the heart rate. Articaine

with submucosal administration in the

oral cavity has a high diffuse ability. Ac-

tive substances to a minimum extent

penetrate the placental barrier, practically

do not stand out with breast milk.

The results of the study:

there Were

several criteria by which the patient’s con-

dition and the action of the anesthetic

were evaluated. The first criterion: the

time of anesthesia. In group I patients, the

anesthetic action began after administra-

tion after 2±1min. In group II and III pa-

tients, the duration of the anesthetic be-

gan as well as in group I after 2±1 min.

The second criterion: the duration of

the anesthetic. From I and III group of

patients the duration of action of anes-

thetic is at least 45min. Have II group of

patients the duration of action of anes-

thetic is at least 75 minutes.

Third criterion: the connection with

the blood supply and toxicity. The degree

of binding to plasma proteins determines

the half-life of the drug, the duration of its

presence in the div. The higher this fig-

ure, the less toxic the anesthetic has, since

it can be absorbed into the blood only in

free form, and the longer the anesthetic

effect. All groups of compounds with

blood proteins is 95%, it gives us a full

right to say that the toxicity of these drugs

is reduced to a minimum.

The fourth criterion: dissociation con-

stant (CD) characterizes the degree of

hydrolysis and ionization of the anesthet-

ic and depends on its chemical structure,

solubility and pH of tissues at the injec-

tion site.

At physiological pH (7.4), the lower the

anesthetic CD, the less molecules dissociate

in the extracellular environment and the

more – inside the cells. For example: CD li-

docaine and mepivacaine is 7.7, which

means that 65 % of the anesthetic is ionized

in the extracellular environment, and 35%

reach the cytoplasm, where the anesthetic

effect is realized (the rate of anesthesia  –

2-4 minutes).As it is told in the summary of

preparations at all groups of tested anesthet-

ics it is revealed that CD is equal to 7,8.

Conclusions

: the results of our studies

showed that all three groups of drugs are

similar to their qualities and parameters.

Thanks to this, the state dental clinics,

which form the basis of the system of

outpatient treatment of dental diseases in

the population, could switch to the use of

advanced anesthesia technology. There-

fore, we can use all three types of anes-

thetic in the rural population.


background image

96

MONOGRAFIA POKONFERENCYJNA

Literature

1. Anisimova E. N. Clinical rationale for the

choice of funds for local anesthesia in out-

patient dental interventions. -Autoref..

kand.honey.sciences’. M.: 1998. – 24 p.

2. Anisimova E. N., Zoryan E. V., Shugaylov I.

A. the Action of local anesthetics and their

combinations with vasoconstrictors. //Den-

tistry. 1998. – Vol. 77. – №2. – P. 19-22.

3. Bazhanov N. N. Experience the use of

adrenaline in dentistry. //Health Care In

Belarus. 1963. – № 4. – p. 81-83.

4. Bazhanov N. N., Ganina S. S. Anesthesia

in polyclinic dental practice. – M.: Medi-

cine, 1979. 192 p.

5. Bizyaev A. F. Local anesthesia. //In kN.: Hand-

book of dentistry (edited by V. M. Bezrukov),

section.2. M. «Medicine»., 1998. – P. 24-48.

Библиографические ссылки

Anisimova E. N. Clinical rationale for the choice of funds for local anesthesia in outpatient dental interventions. -Autoref.. kand.honey.sciences’. M.: 1998. - 24 p.

Anisimova E. N., Zoryan E. V., Shugaylov I. A. the Action of local anesthetics and their combinations with vasoconstrictors. //Dentistry. 1998. - Vol. 77. - №2. - P. 19-22.

Bazhanov N. N. Experience the use of adrenaline in dentistry. //Health Care In Belarus. 1963. - № 4. - p. 81-83.

Bazhanov N. N., Ganina S. S. Anesthesia in polyclinic dental practice. - M.: Medicine, 1979. 192 p.

Bizyaev A. F. Local anesthesia. //In kN.: Handbook of dentistry (edited by V. M. Bezrukov), section.2. M. «Medicine»., 1998. - P. 24-48.

Hepagreen - восстановление нормальной работы печени Androgard — препарат для настоящих мужчин Androgard — препарат для настоящих мужчин Byutivit - Натуральный продукт для женщин любого возраста Byutivit - Натуральный продукт для женщин любого возраста Byutivit - Натуральный продукт для женщин любого возраста Maksimus - Натуральный продукт, для бодрости и энергии Lactovita - Номер один в естественном улучшении иммунитета Lactovita - Номер один в естественном улучшении иммунитета Avicenna’s Lab inLibrary — это научная электронная библиотека UACD - Антикоррупционный дайджест Узбекистана inConference - научно-практические конференции inScience - Журнал Общество и инновации Gulyamov - Гулямов Саид Саидахрарович MUVI24 - Смотрите фильмы онлайн, большая коллекция, новинки кинопроката Megatorg - Доска объявлений Megatorg.net: сайт бесплатных частных объявлений Skinormil - Космецевтика активного действия Pils - Интернет-аптека >METAMED - Фармацевтическая компания с полным спектром услуг All.Tube - Смотрите онлайн видео бесплатно в хорошем качестве Dexaflu - от симптомов гриппа и простуды UMAR PROEKT - Комплексное проектирование UZDA - Ассоциации стоматологов Узбекистана