: local anesthetics are
substances that, when interacting with
nerve fibers and their endings, can revers-
ibly inhibit the formation and conduction
of nerve impulses on them. The effect of
local anesthesia depends not only on the
properties and concentration of the drug,
but also on the thickness of the myelin
sheath of the nerve fiber that prevents the
penetration of the anesthetic through the
cell membrane. Search and improvement
of methods of local anesthesia is one of
the most important tasks of modern den-
tistry. The main task of local anesthesia is
to achieve anesthesia of the necessary tis-
sue area, and all other effects of its action
are considered as side effects. To do this,
we need to know the objective assessment
of the anesthetic.
The aim of our study was
: to Study the
features-actions* of modern domestic ar-
ticaine-containing anesthetic «Supercain»
to improve the efficiency and safety of lo-
cal anesthesia by introducing into dental
practice. Experimentally and clinically jus-
tify the advantages and disadvantages of
anesthetics. Find the optimal use of local
anesthetics in the rural population.
COMPARATIVE EVALUATION OF ANESTHETICS AND THEIR
USE IN THE RURAL POPULATION
Mukimov Odiljon Ahmadjonovich
(assistant of Department of operative dentistry and dental implantology,
the Tashkent State Dental Institute.),
(4th year student of the Tashkent State Dental Institute )
The success of modern dentistry is largely due to the development and implementation
in practice of new tools and methods that allow painlessly carry out long and large – scale
interventions in the oral cavity. The most effective and safe way of anesthesia on an out-
patient dental reception is local anesthesia. For the time being. The most effective of them
are recognized drugs created on the basis of articaine, due to the peculiarities of its phar-
macokinetics and pharmacodynamics. The articaine containing products produced by
various foreign companies and is known for its proprietary trade names: al-fakin (Dens-
ply, France), Articaine of INIBSA (Inibsa, Spain), Prilocain (Russia), Primaquin
(France), Septanest (Septodont, France), Ubistesin (ZM ESPE, Germany), Ultracain
(Sanofi-Aventis, Germany), Cytokeratin (Italy). The main component of all these drugs
is a local anesthetic – articaine, which determines, on the one hand, the General features
of the action of all these drugs, and on the other-their distinctive features in comparison
with drugs created on the basis of lidocaine or mepivacaine. Articaine, lidocaine and
mepivacaine are international nonproprietary names (INN), which are indicated along
with trade names (E. V. Zoryan, S. A. Rabinovich)
anesthetics, rural population, articaine
SCIENCE, RESEARCH, DEVELOPMENT
Materials and methods of research:
1.Clinical examination of patients.
2.Statistical methods of processing the
results of the study.
3. Laboratory research methods.
For the study were taking 30 patients,
which we divided into 3 groups. In group
I the anesthetic Articaine was used. In the
second group used the drug superchain
Forte. In group III, was used in the prepa-
ration supercam.all these drugs are ge-
neric drug Ubistesin. Ubistesin combined
preparation for local anesthesia in den-
tistry. Part of it, the articaine is a local
anesthetic of the amide type titanovoe
group. Due to the low content of epineph-
rine in the drug, its effect on the cardio-
vascular system is expressed little: there is
almost no increase in blood pressure and
an increase in the heart rate. Articaine
with submucosal administration in the
oral cavity has a high diffuse ability. Ac-
tive substances to a minimum extent
penetrate the placental barrier, practically
do not stand out with breast milk.
The results of the study:
several criteria by which the patient’s con-
dition and the action of the anesthetic
were evaluated. The first criterion: the
time of anesthesia. In group I patients, the
anesthetic action began after administra-
tion after 2±1min. In group II and III pa-
tients, the duration of the anesthetic be-
gan as well as in group I after 2±1 min.
The second criterion: the duration of
the anesthetic. From I and III group of
patients the duration of action of anes-
thetic is at least 45min. Have II group of
patients the duration of action of anes-
thetic is at least 75 minutes.
Third criterion: the connection with
the blood supply and toxicity. The degree
of binding to plasma proteins determines
the half-life of the drug, the duration of its
presence in the div. The higher this fig-
ure, the less toxic the anesthetic has, since
it can be absorbed into the blood only in
free form, and the longer the anesthetic
effect. All groups of compounds with
blood proteins is 95%, it gives us a full
right to say that the toxicity of these drugs
is reduced to a minimum.
The fourth criterion: dissociation con-
stant (CD) characterizes the degree of
hydrolysis and ionization of the anesthet-
ic and depends on its chemical structure,
solubility and pH of tissues at the injec-
At physiological pH (7.4), the lower the
anesthetic CD, the less molecules dissociate
in the extracellular environment and the
more – inside the cells. For example: CD li-
docaine and mepivacaine is 7.7, which
means that 65 % of the anesthetic is ionized
in the extracellular environment, and 35%
reach the cytoplasm, where the anesthetic
effect is realized (the rate of anesthesia –
2-4 minutes).As it is told in the summary of
preparations at all groups of tested anesthet-
ics it is revealed that CD is equal to 7,8.
: the results of our studies
showed that all three groups of drugs are
similar to their qualities and parameters.
Thanks to this, the state dental clinics,
which form the basis of the system of
outpatient treatment of dental diseases in
the population, could switch to the use of
advanced anesthesia technology. There-
fore, we can use all three types of anes-
thetic in the rural population.
1. Anisimova E. N. Clinical rationale for the
choice of funds for local anesthesia in out-
patient dental interventions. -Autoref..
kand.honey.sciences’. M.: 1998. – 24 p.
2. Anisimova E. N., Zoryan E. V., Shugaylov I.
A. the Action of local anesthetics and their
combinations with vasoconstrictors. //Den-
tistry. 1998. – Vol. 77. – №2. – P. 19-22.
3. Bazhanov N. N. Experience the use of
adrenaline in dentistry. //Health Care In
Belarus. 1963. – № 4. – p. 81-83.
4. Bazhanov N. N., Ganina S. S. Anesthesia
in polyclinic dental practice. – M.: Medi-
cine, 1979. 192 p.
5. Bizyaev A. F. Local anesthesia. //In kN.: Hand-
book of dentistry (edited by V. M. Bezrukov),
section.2. M. «Medicine»., 1998. – P. 24-48.