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DERMATOLOGY AND VENEREOLOGY
Адхамжон Бегишевич ПАКИРДИНОВ
Кахрамонжон Нажмидинович ХАИТОВ
Кафедра дерматовенерологии
Андижанский Государственный медицинский институт
Кафедра детских кожных и венерических болезней
Ташкентский Педиатрический медицинский институт
THE MECHANISM OF THERAPEUTICAL EFFECT OF LASER THERAPY AND
CREAM CHISTOTEL AT THE PATIENTS WITH THE SKIN ANGEITIS AND
PREPARATION LEFNO AT THE PATIENTS WITH THE ARTHROPATIC FORM OF
PSORIASIS TO THE IgE
For citation: Pakirdinov A.B., Haitov K.N. THE MECHANISM OF THERAPEUTICAL EFFECT
OF LASER THERAPY AND CREAM CHISTOTEL AT THE PATIENTS WITH THE SKIN
ANGEITIS AND PREPARATION LEFNO AT THE PATIENTS WITH THE ARTHROPATIC
FORM OF PSORIASIS TO THE IgE. Journal of Biomedicine and Practice. 2021, vol. 6, issue 3,
pp.105-109
http://dx.doi.org/10.26739/2181-9300-2021-3-16
АННОТАЦИЯ
В статье изучены эффективность лазерной терапии у пациентов с артропатической
формой псориаза и анггитов кожи основанных на изменениях иммунологических параметров.
Было обследовано 50 пациентов. Из них 25 пациентов с ангиитами кожи (10 - мужчин и 15 -
женщин), 25 пациентов с артропатической формой псориаза (12 - мужчин и 13 - женщин).
Была использована лазерная терапия, которая дала положительный эффект у всех пациентов.
Во время лечения показания IgE были приведены в норму.
Ключевые слова:
лазеротерапия, ангииты кожи, артропатическая форма псориаза,
эффективность лазеротерапии, IgE (immunoglobulin - E).
Adhamjon Begishevich PAKIRDINOV
Kakhramonjon Nazhmidinovich KHAITOV
Andijan State Medical Institute
Tashkent Pediatric Medical Institute.
Department of dermatology and venereology
THE MECHANISM OF THERAPEUTICAL EFFECT OF LASER THERAPY AND
CREAM CHISTOTEL AT THE PATIENTS WITH THE SKIN ANGEITIS AND
PREPARATION LEFNO AT THE PATIENTS WITH THE ARTHROPATIC FORM OF
PSORIASIS TO THE IgE.
БИОМЕДИЦИНА ВА АМАЛИЁТ ЖУРНАЛИ
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ЖУРНАЛ БИОМЕДИЦИНЫ И ПРАКТИКИ
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JOURNAL OF BIOMEDICINE AND PRACTICE
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ANNOTATION
The aim of work was to study the effectiveness of laser therapy in patients with arthropatic
form of psoriasis and angiitis of the skin based on changes of immunological parameters. Forty-five
patients were observed. There 25 patients with angiitis (10 males and 15 females), 25 patients with
arthropathic form of psoriasis (12 males and 13 females). In combined use of laser therapy positive
changes were revealed in all the patients. During the treatment concentration of IgE was reduced to
normal limits.
Keywords:
laser therapy, skin angiitis, arthropathic form of psoriasis, low level laser therapy,
IgE (immunoglobulin – E).
Адхамжон Бегишевич ПАКИРДИНОВ
Кахрамонжон Нажмидинович ХАИТОВ
Дерматовенерология кафедраси
Андижон Давлат тиббиёт институти
Болалар тери ва таносил касалликлар кафедраси
Тошкент Педиатрия медицина институти
ТЕРИ АНГИИТИ БИЛАН ОҒРИГАН БЕМОРЛАРИГА ЛАЗЕРОТЕРАПИЯ ВА КРЕМ
ЧИСТОТЕЛНИ ҲАМДА ЛЕФНО ПРЕПАРАТИНИ АРТРОПАТИК ПСОРИАЗЛИ
БЕМОРЛАРИ IgE КЎРСАТКИЧЛАРИГА ТЕРАПЕВТИК ТАЪСИРИ МЕХАНИЗМИ
АННОТАЦИЯ
Ишнинг мақсади иммун статуснинг айрим параметрларидаги ўзгаришлари хисобга
олган ҳолда тери ангиити ва артропатик псориаз билан оғриған беморларда лазер терапия
самарадорлигини ўрганишдан иборат. Қузатувимизда 50 бемор бўлиб, улардан 25 тасида (10
та эркак ва 15 та аёл) тери ангиити, 25 тасида (12 эркак ва 13 та аёл) артропатик псориази
аниқланган. Лазер терапия қўлаш натижасида уларнинг барчасида ижобий ўзгариш, шунинг
билан бирга иммун тизим томонидан қонзардобидан концентрациясининг меъёрий
қўрсатқичларга пасайиши қузатилди.
Қалит сўзлар:
лазер билан даволаш, тери ангиити, артропатик псориаз,
лазертерапиядан эффект, IgE (иммунглобулин - Е).
Urgency.
The problem of treatment of autoimmune dermatosesis enough actual, that is
connected with a significant spread and severe course of dermatosis. Particularly well developed,
drug therapies, as the drugs are not always effective and sometimes is associated with the appointment
of various side effects and complications, sometimes very heavy [1, 2, 3, 4, 5, 6]. One of these effects
is the laser therapy Milta-F-8-01 (Figure1).
Laser therapy is still widely introduced into clinical practice, since it is a relatively safe and
quite effective method of treatment. In recent years, the use of laser therapy for therapeutic purposes
is increasingly used in many disease states. The main objective of laser therapy is a modulation of
adrenergic and cholinergic mechanisms of regulation of metabolic and energy processes [7, 8, 9, 10,
11, 12, 13, 14, 15].
Figure 1: Milta-F-8-01
The purpose of research
- is the study of the
mechanism of laser therapy, therapeutic effect on
immunologic parameters in patients with vasculitis of the
skin and psoriasis Arthropathic.
Materials and methods
. The aim of this work is
to study the effectiveness of laser therapy using gel
Celandine patients skin vasculitis and Lefno the drug in
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patients with psoriasis Arthropathic considering the changes in some parameters of the immune
system.
The study included 50 patients. Of these skin vasculitis suffered 25 patients (10 - men and 15
- women, aged 20 to 50 years), Arthropathic psoriasis - in 25 patients (12 - men and 13 - women,
aged 19 to 45 years). Diseases of different lesions, long and persistent course, resistant to prior
therapy, including several patients to corticosteroids, cytostatics.
Patients with skin angiitis (table number 1, picture number 2) and Arthropathic forms of psoriasis
(table number 1, number 2) has been selected laser therapy mode.
Table №1
Modes irradiation treatment zones in the treatment of skin angiitis
Radiationarea
Terminal
Frequency
Hz
Power LED
smW (laser, W)
Nozzle
Exposition,
minutes
The skin, the
affected area
КТЗ-4
1500-5000
50
№ 7/МN
4-10
Epigastric
ОТ2-3
600
40
№ 7/МN
4-5
Spine, L2-S1
МТ
150-300
30 (50-60)
BN
3-6
Duration of course low-level laser therapy (LLLT) - at least 12-14 procedures.
Table №2
Modes irradiation treatment zones in the treatment of psoriasis Arthropathic
Radiationarea
Terminal
Frequency
Hz
Power
LEDs mW
(laser, W)
Nozzle
Exposition,
minutes
Directedlaserirradiation
КТ1
1500
30
№ 7
4-6
Psoriaticlesions
КТ1
1500-5000
50
№
7/МN
4-6
Spine, Th1-Th2
МТ
150-300
40 (25-30)
BN
2-4
The duration of the course of laser therapy (RT) - at least 12-14 procedures.
The duration of the laser therapy procedure lasts about 2-10 minutes. Treatments were
performed daily, except Sundays. The frequency and number of treatments determined clinical
effectiveness of dynamics and ranged from 12 to 14 laser therapy treatments.
Figure2.
Figure3.
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In addition, patients were: Patients with vasculitis skin lubricated - gel Celandine (smeared II
times a day with a thin layer).
Patients Arthropatic form of psoriasis received the drug "Lefno" 1 tablet 3 times a day, a
course of treatment of 14 days. Externally lubricated - "Cream-balm Seabuckthorn with mummy"
(greased 2 times a day with a thin layer).
IgE levels were determined by enzyme immunoassay. In the control group, received 10
donors, IgE level does not exceed 120.0 ± 3.46 IU/ml. This method was developed by «ABBOTT»
(USA) and is based on the method immunological binding to the solid phase to determine the IgE.
Discussion of the results
Positive dynamics on the background of laser therapy was observed in all patients. Patients
with skin vasculitis treatment laser therapy is the development of resistance to standard therapy with
corticosteroids. In the treatment method of laser therapy and external therapy using "Celandine" gel
contact was found the effectiveness of the skin process - reduced subjective pain, rashes paled, noted
epithelialization of erosions and ulcers. After 8-10 laser therapy procedures noted the cessation of
pain, hemorrhagic lesions regress, epithelization of erosions and ulcers scarring.
In the treatment of laser therapy, the drug "Lefno" and external therapy using "Cream-balm
Seabuckthorn with mummy" in patients Arthropathic form of psoriasis, after 6-8 treatments of
pruritus intensity sharply decreased, decreased subjective pain in the joints, after the 10- 14 laser
therapy treatments resolved psoriatic lesions, exudative components were eliminated and psoriatic
plaques was observed cessation of subjective pain in the joints.
Given the fact that IgE plays a significant role in the pathogenesis of skin angiitis and
Arthropathic psoriasis was advisable to follow the change of its concentration in the blood in these
patients. IgE was determined by the dynamics of skin angiitis 20 patients and 20 patients Arthropathic
form of psoriasis.
Prior to laser therapy and topical treatment with the gel "celandine" in patients with vasculitis
skin IgE levels averaged 518,9 ± 30,5 IU/ml after the treatment of laser therapy IgE level was 479,8
± 24,3 IU/ml. By repeating the procedure of laser therapy was noted in patients with IgE levels
decrease concentration to 157,1 ± 7,3 IU/ml.
Prior to laser treatment in patients arthropathic psoriasis IgE level was on average 597.7 ±
25.8 IU/ml after treatment and laser therapy drug Lefno IgE level was 193.5 ± 19.7 IU/ml.
Conclusions:
As a result of the research we came to the following conclusions:
1. Implementation of laser therapy procedures indicated in patients of skin angiitis, in which
the skin is accompanied by expression of subjective pain, presence of erosions and ulcers.
2. Implementation of laser therapy is indicated in patientsArthropathic psoriasis
accompanying subjective pain sensations in the joints, the presence of psoriatic lesions and plaques.
3. Conduct laser therapy specifically indicated for dermatoses forms that accompany changes
in the immune system.
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