76
3.
Даминова
S.,
и
Маткулиева
S. «Clinical Course of Chronic Viral Hepatitis
C in Children». in Library, т
. 20,
вып
. 3,
октябрь
2020
г
.,
сс
. 1-6,
https://inlibrary.uz/index.php/archive/article/view/14502
4.
Хасанова, Л., and М. Юнусходжаева. "Опыт применения препарата
биоплант для лечения пародонтита." Stomatologiya 1.2 (71) (2018): 22
-24.
COMPLETE DEFECTS OF THE DENTITION IN WOMEN IN EARLY MENOPAUSE
Nurova SH.N.
Bukhara state medical institute
Relevance. This is due to the presence of estrogen receptors in the
exocrinocytes of the terminal sections and cells of the excretory ducts of the
salivary glands. It is known that changes in the properties of saliva affect the
condition of the hard tissues of the teeth, periodontal tissues, oral mucosa and the
microbial landscape of the oral cavity. However, to date, no studies have been
conducted to determine the nature and severity of changes in the functional
parameters of the salivary glands and the parameters of dental status in the early
period of surgical menopause, when the female div finds itself in conditions of a
sharp absolute estrogen deficiency without an adaptation phase to a new
condition.
Purpose
–
features of quantitative and qualitative indicators of mixed saliva,
the main clinical and laboratory indicators of dental status in women with surgical
menopause.
Material and methods. The main objectives of the study included 26
patients, of whom the observation group included 13 women with surgical
menopause without hormone replacement therapy aged 45-56 years; the
comparison group included 13 relatively healthy women of premenopausal age
(45-53 years).
Results and discussion. Thus, a significant decrease in the rate of saliva
secretion was noted against the background of an increase in its viscosity.
Fluctuations in the pH of mixed saliva in women of both compared groups at
stages up to six months were insignificant and were within the normal range,
however, by the twelfth month of observation, an increase in the acidity of the
oral fluid was noted in patients with surgical menopause. Analysis of the
dynamics of the composition of the inorganic components of mixed saliva
revealed a gradual decrease in the concentration of Na and total Ca, an increase in
the concentration of K, while the P content significantly decreased only 12 months
after surgical treatment. Changes in the values of the buffer capacity for acid and
alkali in the examined patients did not have significant differences over the entire
observation period. Changes in the properties of mixed saliva and the volume of
its secretion affected the dental status of women with surgical menopause.
77
After three months, an increase in the amount of points on the
questionnaire for a comprehensive assessment of xerostomia "The Summarized
Xerostomia Inventory
–
XI" was recorded, followed by progression from mild to
moderate xerostomia by the year of observation.
It is known that epithelial cells play one of the central roles in the induction
of a specific immune response at the level of the mucous barrier of the oral cavity,
for this reason, the results of cytological research are interesting. Already at the
early stage of observations in women without HRT, there was a significant
decrease in the values of the epithelial cell differentiation index, which continues
at subsequent stages. In particular, if the initial values of the studied index in the
area of transverse palatine folds were 427±3.7 points, then after 3 months after
surgery they decreased to 397±3.4, after 6 —
to 391±3.6, and after 12 —
to
382±3.6.
Conclusion. In addition to negative changes in the level of differentiation
and keratinization of epidermocytes, their ability to adsorb microorganisms also
worsened, which significantly decreased already at the first stage, reaching a
minimum by the end of observations. It is logical that the revealed decrease in the
amount of saliva, changes in its properties and composition, along with a
weakening of the ability of epithelial cells to neutralize bacteria, could have a
negative impact on the microbial landscape of the oral cavity in patients with
severe hypoestrogenia.
References
1.
Ризаев, Ж.,
and
М. Юнусходжаева. "ОСОБЕННОСТИ ТЕЧЕНИЯ
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Исаходжаева, Хабиба, С. Маликов,
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Даминова, Ш., Маткулиева, С., Назирова, С., & Абдиримова, Г. (2021).
Микробиологические и иммунологические показатели эффективности
лечении детей больных вирусным гепатитом «С».
in Library, 21(2), 134
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139.
извлечено от
https://inlibrary.uz/index.php/archive/article/view/14500
4.
Хасанова, Л.,
and
М. Юнусходжаева. "Опыт применения препарата
биоплант для лечения пародонтита."
Stomatologiya 1.2 (71) (2018): 22-24.
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Daminova, Sh B., and N. N. Kazakova. "The state of the physicochemical
properties of oral fluid in children with rheumatism." ACADEMICIA: An
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6.
Хасанова, Л.,
and
М. Юнусходжаева. "О ИЗУЧЕНИИ СОСТОЯНИЯ
ПРОТЕОЛИТИЧЕСКОЙ АКТИВНОСТИ И АНТИПРОТЕАЗНОГО ПОТЕНЦИАЛА
РОТОВОЙ ЖИДКОСТИ У БОЛЬНЫХ С БЫСТРОПРОГРЕССИРУЮЩИМ
ПАРОДОНТИТОМ." Медицина и инновации 1.4 (2021): 509
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