113
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
EXTEMPORAL CHEWABLE PASTILLES: FROM THE CONCEPT OF THE
DOSAGE FORM TO QUALITY CONTROL
Inkin A.D.
1
Krishtanova N. A.
2
Saint-Petersburg State University of Chemistry and Pharmacy, Saint-Petersburg, Russian
Federation
e-mail: aleksandr.inkin@spcpu.ru
https://doi.org/10.5281/zenodo.17324225
Relevance.
Chewable pastilles combine taste masking, ease of use and the ability to select
individual doses, which is especially valuable in pediatrics, geriatrics and for patients with dysphagia.
For pharmacies, the form is attractive for its technological simplicity, availability of bases (for
example, gelatin) and the possibility of rapid production of small batches. However, methodological
gaps remain: terminological uncertainty and differentiation with related forms, lack of regulated
procedures for quality control and stability in the conditions of extemporal production. Comparison
with the requirements of the Pharmacopoeia and development of simplified, reproducible algorithms
and rapid control methods are critical for safe implementation in pharmacy practice.
Objective:
to study chewable pastilles as a dosage form, to justify their suitability for
extemporal manufacture in a pharmacy and to demonstrate the simplicity of the technological process
and quality control.
Tasks:
1. Clarify the definition of "chewable pastilles", indicate their place in the nomenclature
of dosage forms and distinguish them from chewable tablets, lozenges and pastilles. 2. Justify the
suitability of the mold for extemporal production in pharmacies. 3. Suggest rapid quality control
methods based on the requirements of the Pharmacopoeia.
Materials and methods:
The study was based on pharmacopoeial articles of the State
Pharmacopoeia of the Russian Federation and scientific articles on quality control of chewable
pastilles. The analysis uses the following methods: content analysis, descriptive and comparative
analysis.
Results:
Chewable pastilles are a dosage form in which the active substance is distributed in
an elastic‑plastic, non-flowing base. Unlike pastilles and lozenges, this form is designed for chewing
and is mainly focused on achieving a systemic effect. Organoleptic deficiencies of medicines are
effectively leveled by the use of flavorings and sweeteners, which increases adherence to treatment.
The technological process is relatively simple and involves melting the gelatin mass with subsequent
dosing of the melt into silicone molds. As an express method of quantitative analysis, titrimetry is
suitable after sample preparation, which consists in dissolving the lozenge in a boiling water bath
with subsequent cooling.
Conclusions:
chewable pastilles are a dosage form with an elastic-plastic, non-flowing base,
intended for chewing and mainly systemic action. The mold is technologically available for
extemporal production in pharmacies. Simple technological schemes (gelatin mass melt - dosage into
molds) and express control (titrimetry after dissolution in a water bath) are proposed. For safe
implementation, chewable pastilles should be separated as an independent dosage form and
accelerated methods should be developed according to the requirements of the Pharmacopoeia with
their subsequent validation.
