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BIOCHEMICAL AND BIOPHYSICAL CHARACTERISTICS OF LIVER DISEASE IN
JUVENILE IDIOPATHIC ARTHRITIS
Rodina Irina Konstantinovna, 5th year student, 1 pediatric faculty,
Abdusattorov Shavkat Shokirjon o’gli, 5th year student, 1 pediatric faculty,
Shomuradova Shakhnoza Shavkatovna, assistant, TashPMI,
Department of Pediatric hospital
№
1 with the basics of non-traditional medicine
Introduction:
Juvenile idiopathic arthritis (JIA) is one of the most severe forms of chronic
pathology in children. The high frequency of JIA compared with other diffuse diseases of the connective
tissue, the tendency to early disability and the possibility of systemic manifestations involving the internal
organs in the pathological process dictate the need for timely diagnosis of complications and the selection
of adequate therapy. One of the vulnerable organs in patients with JIA is the liver. The reason is
autoimmune processes on the one hand and the effect of drugs on the other.
Objective:
To study the biochemical and biophysical characteristics of liver damage in juvenile
idiopathic arthritis.
Materials and research methods
: 44 patients with JIA were examined aged from 1.5 to 18 years.
Among these patients, 17 of them with oligo and 27 with polyarthritic variants of the disease. In details,
among 44 patients, 21 (47.7%) of them were boys and 23 (52.3%) were girls. The duration of the disease
ranged from 1 year to 10 years. The activity of the enzymes AlAT, GGT and ALP, the content of total
protein, albumin, bilirubin, total cholesterol, and thymol sample were studied. Liver elastography was
performed using a FibroScan 502 TOUCH medical equipment (EchoSens, France).
Results and discussion:
among 64.8% of patients with JIA, liver damage was revealed, which
manifests itself in all cases as signs of mesenchymal inflammation, 74.6% of them with hypoalbuminemia,
64.4% - hyperbilirubinemia, 35.6% - cholestasis and 15.2% of patients with hyperenzymemia before 2
norms respectively. According to liver elastography among 13
patients with juvenile idiopathic arthritis disease, 10 (76.9%) of them showed no signs of fibrosis (F0).
Minimum fibrosis (F1) was diagnosed in 2 (15.4%) patients and moderate fibrosis (F2) in 1 (7.7%)
respectively. Severe fibrosis and cirrhosis were not detected. Fibrosis was assessed using the METAVIR
scale. The average indicator of liver elasticity was 3.5 ± 0.5 kPa for F0, 5.8 ± 0.5 kPa for F1 and 6.5 ± 1.5
kPa for F2 stage of fibrosis, respectively.
Conclusion:
In JIA patients receiving basic therapy for 5 years or more, 35.4% of cases develop
liver damage of medicinal origin, ultrasound elastography allows early detection of fibrosis and monitoring
of MTX toxicity of the liver.
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