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Азимова Камола Талъатовна,
ассистент кафедры педиатрии №3,
Самаркандский государственный медицинский институт
Шавази Шавази Нурали Мухаммад угли
,
Д.м.н., профессор, заведующий кафедрой педиатрии №1,
Самаркандский государственный медицинский институт
Закирова Бахора Исламовна,
к.м.н., доцент кафедры педиатрии №1,
Самаркандский государственный медицинский институт
Карджавова Гульноза Абилкасимовна.
ассистент кафедры педиатрии №1,
Самаркандский государственный медицинский институт
ОБСТРУКТИВНЫЙ БРОНХИТ У ДЕТЕЙ: ВЗАИМОСВЯЗЬ МИКРОЭКОЛОГИИ КИШЕЧНИКА С
КЛИНИЧЕСКОЙ ХАРАКТЕРИСТИКОЙ
For citation:
Azimova Kamola Talatovna, Shavazi Nurali Mukhammadovich, Zakirova Bakhora Islamovna
,
Kardjavova
Gulnoza Abilkasimovna\ Obstruktive bronxitis in children: relationship of intestinal microecology with clinical characteristics.
Journal of hepato-gastroenterology research. 2020, vol. 3, issue 1, pp. 9-11
http://dx.doi.org/10.26739/
2181-1008-2020-3-2
АННОТАЦИЯ
Обследовано 52 больных детей с острым обструктивным бронхитом. Микрофлора кишечника изучена по
общепринятой методике. Выявлена взаимосвязь показателей кишечной микробиоты с тяжестью клинических
симптомов при остром обструктивном бронхите у детей. Дисбиотические нарушения микрофлоры кишечника
взаимосвязаны со степенью тяжести клинических проявлений, отражаясь на функциональной способности желудочно-
кишечного тракта, способствуют сенсибилизации организма и усилению бронхообструкции.
Ключевые слова
. Острый обструктивный бронхит у детей. Кишечная микрофлора.
Azimova Kamola Ta’latovna,
3-sonli pediatriya kafedrasi assistenti,
Samarqand Davlat Tibbiyot Instituti
Shavazi Nurali Muxammad o’g’li,
t.f.d., professor, 1-sonli pediatriya kafedrasi mudiri,
Samarqand Davlat Tibbiyot Instituti
Zakirova Bahora Islamovna,
t.f.n., 1-sonli pediatriya kafedrasi dotsenti,
Samarqand Davlat Tibbiyot Instituti
Kardjavova Gulnoza Abilkasimovna.
1-sonli pediatriya kafedrasi assistenti,
Samarqand Davlat Tibbiyot Instituti
BOLALARDA OBSTRUKTIV BRONXIT: ICHAK MIKROEKOLOGIYASINING KLINIK XUSUSIYATLARIGA
BOG’LIQLIGI
ANNOTATSIYA
O’tkir obstruktiv bronxit bo’lgan 52 ta bemor bola ko’rikdan o’tkazildi. Ichak mikroflorasi standart usuli yordamida
o’rganildi. Bolalardagi o’tkir obstruktiv bronxitning og’irlik daraja simptomlari ichak mikrobiatasining ko’rsatkichlari bilan
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bog’liqligi ko’rsatilgan. Ichak mikraflorasining disbiotik buzulishlari, organizmning sensibilizatsiyasi va bronxoobstruktiyani
kuchaytirilganini aks ettiradi.
Kalit so’zlar
. Bolalarda o’tkir obstruktiv bronxit. Ichak mikroflorasi.
Azimova KamolaTalatovna
Assistant of the department of pediatrics №3
Samarkand State Medical Institute
Samarkand Uzbekistan
Shavazi Nurali Mukhammadovich
Doctor of Medical Sciences, Professor,
Head of the Department of Pediatrics №1
Samarkand State Medical Institute
Samarkand Uzbekistan
Zakirova Bakhora Islamovna
Candidate of Medical Sciences, Associate Professor
of the the Department of Pediatrics №1
Samarkand State Medical Institute
Samarkand Uzbekistan
Kardjavova Gulnoza Abilkasimovna
Assistant of the department of pediatrics №1
Samarkand State Medical Institute
Samarkand Uzbekistan
OBSTRUCTIVE BRONCHITIS IN CHILDREN: RELATIONSHIP OF INTESTINAL MICROECOLOGY WITH
CLINICAL CHARACTERISTICS
ANNOTATION
52 children with acute obstructive bronchitis were examined. The intestinal microflora was studied according to the
generally accepted method. The relationship of intestinal microbiota indicators with the severity of clinical symptoms in acute
obstructive bronchitis in children was revealed. Dysbiotic disorders of the intestinal microflora are interrelated with the severity
of clinical manifestations, affecting the functional ability of the gastrointestinal tract, contribute to the sensitization of the div
and increase bronchial obstruction.
Keywords.
Acute obstructive bronchitis in children. intestinal microflora.
Relevance.
It is known that acute obstructive bronchitis is
diverse in form and severity and respiratory failure and
laryngeal stenosis play an important role in its course, which
can be fatal in the absence of timely and urgent care [1].
Conditionally pathogenic flora with prolonged persistence in
the div of a sick child enhances dysbiosis and contributes to
the formation of bacterial sensitization with the subsequent
development of respiratory allergy [2]. It has been proven [1]
that a violation of the intestinal microecology often plays a
decisive role in the mechanisms of immunoresistance and
metabolism, allergies and inflammation. Hence the importance
of studying the state of metabolism, the course of respiratory
diseases that occur with obstruction and stenosis, depending
on the state of the intestinal microbiota of children [3].
Objective.
Identify the relationship between indicators of
intestinal microbiota and the severity of clinical symptoms and
laboratory data in acute obstructive bronchitis in children.
Material and methods.
The study involved 52 patients of
early age with acute obstructive bronchitis hospitalized in the
SF of the Center for Emergency Medical Treatment. The
intestinal microflora in the dynamics of the disease was studied
according to the generally accepted method of seeding feces,
developed by R.V. Epstein-Litvak, F.A. Vilshanskaya
modification MA Akhtamova et al. [4]. In the diagnosis of
microbial imbalance, the classification was used by Blokhina
I.N. [5].
Results.
We studied the effect of the role of intestinal
microflora in the development of clinical and laboratory
manifestations
of
acute
obstructive
bronchitis
in
children.When studying the correlation between the severity
of the condition of children and the level of obligate microfor
in patients, it was found that the more severe the condition of
the patients, the lower the concentration of Bifidobacterium
and Lactobacillus (r = -0,701 and r = -0,689), i.e. there was a
close inverse correlation relationship. The level of lactose-
positive Escherichia also decreased in patients with severe
disease, but correlations were weak (r = -0.458) in nature. The
same weak but direct correlations were observed with the ratio
of the severity of sick children with acute obstructive
bronchitis and conditionally pathogenic flora - Klebsiella and
Citrobacter (r = +0.522 and r = +0.504, respectively). When
the ratio of the severity of the condition of sick children with
acute obstructive bronchitis and the level of pathogenic flora
was revealed close direct relationship. Thus, the correlation
indicator when comparing Staphylococcus aureus and E. coli
gemoliticus was r = + 0.707 and r = + 0.710, respectively. The
moderate degree of relationship was between the level of
Candida fungi (r = +0.602) and the severity of the condition of
sick children with acute obstructive bronchitis. When
comparing the number of Bifidobacterium and Lactobacillus
with the severity of the degree of obstructive syndrome (r = -
0.650 and r = -0.619), an inverse correlation relationship was
found. Thus, an analysis of studies has shown the presence of
correlations between the main clinical symptoms in children
with acute obstructive bronchitis and the composition of the
intestinal microbiota.
Findings.
Thus, in sick children with acute obstructive
bronchitis, dysbiotic disorders of the intestinal microflora are
closely interrelated with the severity of clinical manifestations,
affecting the functional ability of the gastrointestinal tract,
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contribute to the sensitization of the div and enhance
bronchoconstruction.
Список литературы/Iqtiboslar/References
1.
Zaitseva O. V. Bronchoobstructive syndrome in children // Pediatrics. - 2005. - №4. - P. 94-104;
2.
Dysbiosis of the ecosystem of the organism in frequently ill children: current methods of diagnosis and treatment / O. V.
Kladova, Yu. I. Sternin, F. S. Kharlamov, L. I. Feldfix, V. F. Uchaikin // Doctor.Ru. - 2011. - №5 (64). - P. 29-34.
3.
Clinical features of intestinal dysbacteriosis in children with recurrent bronchopulmonary diseases / I. A. Savelyeva, E.
M. Butenina, A. B. Lebedeva, F. D. Akulova // Actual issues of clinical Microbiology: Republican collection of scientific
works. labours'. M., 2005. - P. 129-131
4.
Akhtamov M. A., Rakhimov A. H., Sidikova K. A. and others. Etiology, bacteriological diagnosis and treatment of
intestinal dysbacteriosis. Methodical recommendation. Tashkent, 1981, 14 p.
5.
Blokhina I. N., Dorofeyuk V. G. Dysbacteriosis. - JI.: Medicine, 1999.- 176 p.
