The mechanism of action of the alkaloid 1-(2´-bromine-4´,5´-dimethoxyphenyl) - 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-18) on the functional activity of smooth muscle cells of the rat aorta was studied. Isometric contraction activity was recorded using a Grass FT – 03 (Grass Instrument, USA) mechanotron. The relaxant effect of the F-18 alkaloid was found to be associated with blockade of Ca2 + (IP3R) channels in the SR, along with voltage- dependent and receptor-operated Ca2+channels in the aorta smooth muscle cell plasmalemma.
Higher convergences of fat and protein just as every one of the micronutrients were available in the stems of S. indica. Centralizations of alkaloid were higher in the leaves and stems of S. cayennensis where as more elevated level of protein was identified in the leaves. More noteworthy degree of hydrogen cyanide was found in the leaves of the two plants. Information were considered genuinely critical at P≤0.05. Nonetheless, high grouping of hydrogen cyanide, an intense poison, recognized in both the leaves and stems of the plants render them unpalatable without appropriate handling. In this way, the usage of these plants in ethno medication as food and medication could be deadly; consequently, it is exceptionally debilitate. Regardless, the bioactive mixtures and supplements could be removed for advancement of medications and food supplements.