The article defines the objectives of agricultural development in the system of territorial division of labor for the future, taking into account the emerging conditions of increasing water scarcity and
environmental tension, and developed proposals for the reorientation of the territorial and intersectoral structure of the agro-industrial complex of the Republic on the basis of improving the specialization of agricultural production.
At the same time, the main principles of the mechanism of economic regulation in the agro-industrial complex, capable of ensuring intersectoral changes taking into account the interests of the Republic, regions and producers of products, have been identified.
The main purpose of the research is to define the task in the areas of poverty reduction, socio-economic development of the regions, transformation of enterprises with state participation, formation and
implementation of investment policy, development of entrepreneurship in the country.
The article defines the priority directions of development of the Samarkand region, highlights the issues of personnel training and cluster centers, the organization of clusters of skilled workers as a mechanism for effective employment. The economy of the Samarkand region is analyzed, the potential of the districts and cities of the region is assessed, proposals are made on areas of competitive advantages, points of growth, and effective distribution of labor
resources.