Objective: to study the significance of risk factors in the development of clinical forms of Covid-19 in school- age children. Material and methods. A retrospective study of the medical records of schoolchildren who have undergone Covid-19 disease was carried out, confirmed by a positive laboratory test for the presence of RNA or SARS-CoV-2 antigen. All children included in the study were randomly divided into 2 groups depending on the severity of the infection. Group 1 included 30 children with asymptomatic Covid-19. The second group consisted of 82 children with mild and medium-severe forms of Covid-19 and 3 children with severe forms of Covid-19. Results. The study calculated the relative risks of developing clinical forms of Covid-19 (mild, medium-severe and severe) in school-age children. It was found that the relative risk of developing clinical forms of Covid-19 is significantly higher in children: with perinatal CNS lesions by 1,299 times (p <0,05), with low resistance to acute infections (more than 4 times a year) by 1,249 times (p < 0,05), with allergic diseases (dermatitis, rhinitis, bronchial asthma) 1,301 times (p <0,05), with a body mass index (BMI) more than + 2 SDS, taking into account the child's age and sex, 1,307 times (p < 0,05), with the age of 15 years and older – 1,459 times (p <0,05). Conclusion. Thus, the incidence of severe clinical forms of Covid-19 in the general structure of infected children is 2,6 %, while the risk factors for the development of clinical forms of Covid-19 are perinatal CNS injuries, allergic diseases, obesity, low resistance to infectious diseases and adolescence. age (15-17 years old).