The influence of dannonal on the functional condition of liver has been studied in toxic hepatitis. It was determined that dannonal increased content of protiens and improved detoxication function of liver by decreasing activity of cytolitic enzymes ALT and AST, decreasing cholestatic markers - APh and GGT. Dannonal showing hepatoprotective action improves function of liver and do not resign to other hepatoprotector - LIV-52.
This article presents the results of a study of the hepatoprotective properties of the herbal drug darmonal in combination with phytin compounds in experimental animals (rats) with experimental hepatitis caused by SS14 intoxication. The obtained research results showed that darmonal in combination with phytin compounds increases the synthesis of total protein and normalizes the composition of protein fractions of blood serum. Both studied drugs have a high level of hepatotropic effect. The combination of darmonal and fitin-C was the most effective. According to this effect, they were superior to the hepatoprotective drug LIV-52.
This article presents the results of a study of the hepatoprotective properties of the herbal drug darmonal in combination with phytin compounds in experimental animals (rats) with experimental hepatitis caused by SS14 intoxication. The obtained research results showed that darmonal in combination with phytin compounds increases the synthesis of total protein and normalizes the composition of protein fractions of blood serum. Both studied drugs have a high level of hepatotropic effect. The combination of darmonal and fitin-C was the most effective. According to this effect, they were superior to the hepatoprotective drug LIV-52.
The study aimed to investigate the protective mechanisms of substance Darmonal and phytin compounds in the experimental model of acute toxic drug-induced hepatitis caused by paracetamol in rats.
The material and methods The research was carried out on white outbred rats of both sexes weighing 140-200 g. Drug-in¬duced liver damage was reproduced by introduction of paracetamol into the stomach in dose 500 mg/kg for 2 days. The test compounds Darmonal, Fitin-C and reference drug Liv.52 were administered for 7 days after hepatitis reproduction in doses 100 mg/kg. The effectiveness and mechanism of action for selected supramolecular complexes in the model of toxic drug-induced hepatitis was made by paracetamol. It was researched that liver protein-synthesizing function was due to the content of total protein and albumin in the blood serum, the excretory and toxic function of the liver by the content of total and direct bilirubin as well as the endogenous intoxication were according to the content of urea in the blood serum, but cytolytic syndrome occurred because of the activity of indicator enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in blood serum).
Research results. The study of specific activity of Darmonal in combination with Fitin-C and the reference drug Liv.52 on the model of paracetamol and carbon tetrachloride hepatitis showed that the drugs, being administered in dose 100 mg/kg, had a pronounced hepatoprotective effect.
The aim of study was to research the effect of darmonal and phytin compounds on the amount of glycogen and lactic acid in the liver tissues.
Materials and methods. The new compounds of phytin-C were studied: phytin-C, cobalt phytate and patent substance of darmonal obtained from wheat grain cells grown under special conditions. For comparison, the bioflavonoid of plant origin Liv-52, being used in treatment of liver diseases, was also studied. The study was carried out on 60 white rats weighing 120-150 g. The toxic hepatitis was caused by subcutaneous administration of 50% carbon tetrachlormetan oil solution in dose 0.8 ml/100 g for 4 days.
Results. The results showed that the combined introduction of extract significantly enlarged the outcome at joint use drug Liv-52 in animals, and, especially such effect was noticeable with addition phytin-C. The use bioactive substance in combination with complex phytin compound was more effective for accumulation of glycogen in the liver than using the drugs separately, hepatotoxin - carbon tetrachlormetan reduced carbohydrate metabolism and led to increase glycogen in liver tissues as well as the decreased lactic acid. It was determined that the combined treatment was more effective at toxic hepatitis induced by carbon tetrachlormetan, it had the hepatoprotective effect and improved liver function.
The influence of darmonal on the functional condition of liver lias been studied in toxic hepatitis. It was determined that darmonal increased content of protiens and improved detoxication function of liver by decreasing activity of cytolitic enzymes ALT and AST, decreasing cholestatic markers - APh and GGT. Darmonal showing hepatoprotective action improves function of liver and do not resign to other hepatoprotector - silibor.
The influence of dannonal on the functional condition of liver has been studied in toxic hepatitis. It was determined that dannonal improved detoxicational function of liver by decreasing activity of cytolitic enzymes ALT and AST, decreasing cholestatic markers - APh and GGT. Dannonal showing hepatoprotective action improves function of liver and do not resign to other hepatoprotector - LIV-52.
Study of the effect of darmonal and phytin compounds on the exocrine function of the liver in acute experimental hepatitis. At the beginning of experimental hepatitis, these drugs were administered orally at a dose of 100 mg/kg. The results obtained led to an increase in the exocrine function of the liver under the influence.