The aim of the investidation was to evaluate activity of a non-specific link of the body protection for experimental bacterial-immune periodontitis and to find out the effects of flavonol quercetin on its parameters. The article presents the results of indices phagocytic activity of blood granulocytes by phagocyte index and phagocyte number on the 14 th day, in the period the most expressed manifestation of the experimental bacteri-
al-immune periodontitis and after correction with quercetin (on the 14 th day). In this case, the character of changes in phagocytic activity in the process of inflammatory site formation in the periodontal complex was determined. The use of quercetin, which acting immune processes, limited the inflammatory response in the periodontal tissues and led to a decrease in the activity of the non-specific immune cell relative to the rates of
animals that did not take the medicine. These indices were near to the control group, but did not reach their
The article presents the results of research of the cytokine link of immune system in the experimental animals -white rats, which were determined by the level of proinflammatory and anti-inflammatory cytokines in blood serum of the intact animals and on the 30th day for experimental periodontitis development. For that characterised changes of the cytokine mechanism more expressed in a late stage of the experimental bacterial-immune periodontitis. In particular, in the period of chronic inflammatory response, on the 30th day of the study, were increased concentrations of IL-ip and TNF-a, while the IL-10, IL-4 content decreased in these conditions. At that, the ratio of pro- and antiinflammatory cytokines (IL-13 / IL-10) as an important indicator of the immune response was increased. Based on these results, it was proved that the formation of the pathological process in the periodontal complex is accompanied in a result of imbalance in the cytokinogenesis system for the late period of the inflammatory response development, that evidence their leading role in the regulation of the immune-inflammatory response in this modeled pathological process.
The purpose of the study was to evaluate the activity of neutrophils in the blood under the condition of the experimental bacterial-immune periodontitis and to clarify the effect of flavonol quercetin on its parameters. The article presents the results of research on the indices of the spontaneous and activated test with nitrosin tetrazolium on the 14th day of the experimental bacterial-immune periodontitis and after correction with quercetin (in the same period of the experiment). In this case, data on the nature of changes in neutrophilic activity in the process of formation of inflammatory focus in the periodontal complex are given. The use of flavonol quercetin, which, acting on the immune processes, limited the inflammatory response in the periodontal tissues and led to a decrease in neutrophil activity relative to the rates of animals that did not receive the drug. As a result of the use of quercetin, the activity of neutrophils approached the values of the control group.
The inflammatory process in the periodontium is the most widespread among dental diseases, that is
characterized by a recurrent course and significantly reduces the quality of life patients. Existing data about
structural and pathomorphological changes in the tissues of the periodontal complex for the of inflammation
development does not explain largely the patterns of the destructive phenomena development in this pathology.
and therefore require additional research. The purpose of this study was to determine the peculiarities of struc-
tural components of periodontal complex and their changes on the 7 th day of the experimental bacterial-
immune periodontitis development. In the study of intact animals, it was found that connective tissue of its own
plate is represented by collagen fibers, forms high connective tissue papillae and closely adheres to the epithe-
lium. The histological study showed that on the 7th day of the experimental bacterial-immune periodontitis de-
velopment of typical and spread inflammatory reaction onto all periodontium was observed. However, the se-verity of this reaction was different in the structural components of the periodontium. Fibroblasts were the most often found among cellular elements, less frequently – histiocytes, lymphocytes, single plasmacytes and mono-cytes. It was an increase of the fibroblasts number, that perform the resorptive functionof collagen fibers and reduce number of active osteoblasts. All these pathomorphological changes testified about of the inflammatory process development