CLINICAL PHARMACOLOGY OF ANTIMICROBIAL RESISTANCE: CHALLENGES AND THERAPEUTIC PERSPECTIVES

Antimicrobial resistance (AMR) has emerged as one of the most serious global health threats of the 21st century, compromising the effectiveness of essential drugs and increasing morbidity, mortality, and healthcare costs. Clinical pharmacology plays a vital role in understanding the mechanisms, optimizing therapeutic regimens, and developing new strategies to counteract resistance. This paper examines the pharmacokinetic and pharmacodynamic principles underlying antimicrobial therapy, highlights the clinical challenges posed by resistant pathogens, and explores future therapeutic perspectives. The study underscores the importance of individualized therapy, stewardship programs, and novel drug discovery in mitigating the global burden of AMR.