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HYPOVITAMINOSIS D - A RISK FACTOR FOR OBSTRUCTIVE BRONCHITIS
RECURRENCES IN CHILDREN
Khasanova Guzaliya Marsovna,
Kayumova Maftuna Hasan Kizi
Tashkent Pediatric Medical Institute, Republic of Uzbekistan, Tashkent city
Scientific adviser: Doctor of Medical Sciences, Professor Agzamova Sh.A.
Relevance.
Respiratory pathology, including obstructive bronchitis in young children, remains one
of the urgent problems of modern pediatrics. It is known that acute lower respiratory tract infections
are one of the leading causes of child mortality in the world, accounting for about 1.4 million deaths
annually in children under 5 years of age. The prevalence of acute obstructive bronchitis, according
to various sources, is 25-30%, while in 30-50% of cases the disease has a recurrent course. A family
or individual history of allergy and eosinophilia are well-studied risk factors for recurrent episodes
of broncho-obstructive syndrome. At the same time, the role of vitamin D is being actively studied
today, as well as the importance of its deficiency in the tendency to recurrent respiratory infections.
Purpose of the study:
to study the level of vitamin D supply in young children prone to recurrent
obstructive bronchitis.
Materials and methods
. We examined 120 children aged 6 months to 3 years with a diagnosis of
acute obstructive bronchitis, among them group I consisted of 60 children with episodic obstructive
bronchitis (less than 3 episodes during the previous year) and group II - 60 children with recurrent
obstructive bronchitis (3 or more episodes during the previous year). All children underwent
clinical and anamnestic examination, laboratory tests (determination of the concentration of 25-
hydroxyvitamin-D (25 (OH) D) in the blood serum by the electrochemiluminescence method).
When analyzing the provision of children with vitamin D at a concentration of 25 (OH) D, the
following criteria recommended by the National Program of the Russian Federation for vitamin D
provision were taken into account: an adequate level of vitamin D - more than 30 ng / ml (75 nmol
/ l); insufficiency —21-30 ng / ml (51-75 nmol / l); deficiency - less than 20 ng / ml (50 nmol / l);
severe deficiency - less than 10 ng / ml (less than 25 nmol / l). When analyzing the data obtained,
nonparametric statistical tests were used. The difference between the indicators was considered
significant at p <0.001). To determine risk factors, we calculated the relative risk (RR), 95%
confidence interval (95% CI) and p-value
Results.
We found that in children with recurrent obstructive bronchitis, the mean serum 25 (OH)
D content was significantly lower than in patients with episodic obstructive bronchitis (13.68 [7.96;
19.51] ng / ml and 33, 0 [28.19; 41.97] ng / ml, respectively, p <0.001). In 75% of cases in group
II, the level of vitamin D supply corresponded to the deficiency criteria (the level of 25 (OH) D in
the blood serum is below 20 ng / ml) compared with group I, where this indicator was 6.6% (%2 =
57.98 , p <0.001). Calculation of the relative risk indicators showed that the risk of recurrent
obstructive bronchitis in children during the first three years of life increases several times in the
presence of 25 (OH) D deficiency in the blood serum (RR = 4.347; 95% CI 2.752-6.866; p <0.001).
Findings.
Vitamin D deficiency can be considered a predictor of recurrent obstructive bronchitis
in young children.
References
1.
Agzamova, Shoira. "Value of heart rate variability parameters in prognosis of intrauterine
infection of infants with cytomegalovirus." Medical and Health Science Journal 4 (2010): 24-
30.
2.
Агзамова, Ш. А. "Характеристика нарушений вентиляции легких у детей с острыми и
рецидивирующими бронхитами." Вопросы современной педиатрии S (2006): 11a.
