2025
SENTABR
NEW RENAISSANCE
INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE
VOLUME 2
|
ISSUE 9
60
HEPATIC ENCEPHALOPATHY IN SEVERELY BURNED PATIENTS
Asadov Asatillo
Asadov Mukhamadullo
Bakhodyrov Javokhir
Avazova T.A.
Supervisor: PhD.
Samarkand State Medical University
Uzbekistan, Samarkand.
https://doi.org/10.5281/zenodo.17115265
Introduction
Hepatic encephalopathy (HE) is a complex of potentially reversible neuropsychiatric
disorders that develop as a consequence of acute or chronic liver failure and/or portosystemic
shunting of blood. According to the literature, in patients with burn disease HE develops in 30
–
45% of cases during the post-shock period.
Aim of the study
To evaluate the impact of liver dysfunction in patients with extensive thermal injuries on
the development of hepatic encephalopathy, as well as to determine the effectiveness of including
Hepotek
(L-ornithine L-aspartate) in the complex therapy.
Materials and methods
The study included 50 patients aged 20
–
60 years with thermal burns covering 20
–
45% of
the div surface area, who presented with clinical manifestations of HE. Patients were divided
into two groups of 25 each:
Group 1
—
received standard traditional therapy;
Group 2
—
in addition received
Hepotek concentrate
at a dose of 10 ml daily for 10 days,
depending on the severity of HE.
Clinical manifestations, liver function tests, and the dynamics of encephalopathy
symptoms were evaluated.
Results
Liver dysfunction was most frequently observed during the toxemia and septicotoxemia
stages (45.5%). Clinical manifestations of CNS involvement were identified in 87.9% of patients
and were characterized by drowsiness, lethargy, loss of appetite, asthenia, and emotional
indifference. In 75.8% of cases, more severe symptoms were observed, including psychomotor
agitation, delirium, hallucinations, asterixis (“flapping tremor”), foot clonus, and impaired
performance in the number connection test (Reitan test).
Signs of toxic hepatitis were registered in 27 patients (54%), manifested by hepatomegaly,
subicterus of the skin and sclera, vomiting, decreased prothrombin index, hyperbilirubinemia, and
increased levels of ALT, AST, alkaline phosphatase, urea, and ammonia.
Under traditional therapy, the manifestations of toxic encephalopathy regressed, but in the
control group (Group 1), 75.6% of patients still demonstrated lethargy, asthenia, drowsiness,
irritability, and asterixis.
2025
SENTABR
NEW RENAISSANCE
INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE
VOLUME 2
|
ISSUE 9
61
In contrast, in Group 2 patients treated with
Hepotek
, toxic hepatitis progressed in a more
compensated manner, and manifestations of liver failure were less pronounced.
Conclusions
The inclusion of
Hepotek
in the complex therapy of patients with extensive deep burns
contributes to a more favorable course of toxic hepatitis. It reduces the severity of liver failure and
the degree of functional impairments, as evidenced by improvements in clinical and biochemical
parameters and regression of hepatic encephalopathy symptoms.
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Азимова, А. А., Абдухоликов, С. Х., & Бозоров, Х. М. (2023). Осложнение
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