CHARACTERISTICS OF UROGENITAL TRACT MICROBIOCENOSIS IN WOMEN WITH NON-DEVELOPING PREGNANCY

685

ResearchBib IF-2023: 11.01, ISSN: 3030-3753, Valume 1 Issue 10

CHARACTERISTICS OF UROGENITAL TRACT MICROBIOCENOSIS IN WOMEN

WITH NON-DEVELOPING PREGNANCY

Rajabova Oygul Islomovna

Asian International University

oygul.islomovna.1997@mail.ru

https://doi.org/10.5281/zenodo.14528590

Abstract.

This article examines the characteristics of urogenital tract microbiocenosis in

women with a history of fetal failure.

Key words:

uterine, non-developing pregnancy, reproductive system, microbiocenos ,

genitourinary tract, vaginos, antibacterial drugs, pathology.

ХАРАКТЕРИСТИКА МИКРОБИОЦЕНОЗА УРОГЕНИТАЛЬНОГО ТРАКТА У

ЖЕНЩИН С НЕРАЗВИВАЮЩЕЙСЯ БЕРЕМЕННОСТЬЮ

Аннотация.

В статье рассматриваются особенности микробиоценоза

урогенитального тракта у женщин с фетальной недостаточностью в анамнезе.

Ключевые слова:

матка, неразвивающаяся беременность, репродуктивная

система, микробиоценоз, мочеполовой тракт, вагиноз, антибактериальные препараты,

патология.

Relevance:

The retention of a dead embryo in the uterine cavity poses a great threat not

only to the health, but also to the life of a woman. The severity of complications during a non-

developing pregnancy is directly proportional to the duration of stay of the dead fertilized egg in

the uterine cavity. Artificial termination of pregnancy has an adverse effect on a woman’s health

and her reproductive system, and is one of the main causes of gynecological morbidity and

subsequent disorders of generative function.

Purpose of the study

: to study the microbiocenosis of the genitourinary tract in women

with non-developing pregnancy

Materials and methods of research

: The most interesting, in our opinion, is the study of

the role of an infectious agent in the etiology of non-developing pregnancy, namely, bacterial

infection and STIs.The women were divided into 2 groups and underwent bacteriological

examination of vaginal contents, the cervical urethra, as well as the content of antibodies to the

most common STIs, such as CMV, HSV, ureoplasma, chlamydia, mycoplasma, as well as

toxoplasmosis and brucellosis.In group 1, 56.2% of women had clinically manifest forms of

infection of the female genital organs. During a bacteriological study, conditionally pathogenic

and pathogenic flora were identified in 52.7% of cases. Microflora was represented by pyogenic

streptococcus - in 45.9%, Escherichia coli - in 21.3%, Candida fungi - in 21.4%, gardnerellosis -

686

ResearchBib IF-2023: 11.01, ISSN: 3030-3753, Valume 1 Issue 10

in 14 .8%, fecal streptococcus – in 11.5%, trichomoniasis – 8.2% of cases.The depressing fact is

that, along with conditionally pathogenic and pathogenic flora, in the 1st group of those examined,

the presence of STIs was detected in 72.6%. Inflammatory diseases of the female genital organs

were noted in the 2nd main group - in 62.7% of women. Conditionally pathogenic and pathogenic

flora were also found in group II - in 60.7% of women. Bacterial vaginosis was detected in 25.0%

of patients in the main group.In every fifth of them, vaginosis was combined with a mixed infection

(22.9%), in which there were 2-3 or more associated microbes, and the bacterial contamination

rate ranged from 105 to 106 CFU/ml. In 51.4% of women in group II, candidiasis, represented by

fungi of the genus Candida, was detected. It should be noted that over the last decade, there has

been an increase in contamination of the external genital organs with fungi of the genus Candida

by more than 2 times, respectively, from 21.4% (1998-99) to 52.9% (2004).

Results and discussion:

The next most numerous microorganisms seeded from the

cervical canal were represented by streptococci - 11.2%, then by a group of enterobacteria, the

overwhelming number of strains of which were represented by Escherichia coli - 9.7% Enterob.

Cloacae was detected in 4.2% of cases, Staphylococcus epidermidis was cultured in 2.7% of cases,

Citrobacterium diversus - in 1.59%, Staphylococcus aureus - in 0.98% of cases, Trichomonas - in

1.6%.

Detection rate of TORCH infection

: antibodies to HSV were detected in 30% of cases,

to CMV - in 36.7%, anti-chlamydial antibodies - in 26.7%, a combination of HSV and CMV - in

28.2%, a combination of chlamydia, HSV and CMV - in 32.8%. The combination of TORCH

infection with bacterial flora was detected in 72.4% of women.

In our opinion, the above is due to the irrational use of antibacterial drugs in women of

fertile age, the high infectious index in this group of women, and, possibly, the inattentive attitude

of obstetricians and gynecologists to this pathology. At the same time, the latest data from the

world literature indicate the leading role of fungi as pathogenic microflora in the human div,

with high resistance to antifungal drugs. We determined the sensitivity of all isolated

microorganisms to antibacterial drugs. Analysis of the results obtained showed that the sensitivity

of these microorganisms to antibacterial drugs has changed.

Thus, if, according to analyzes of retrospective results, the most effective antibiotics in

1996-1998 were carbenicillin (55.0%), oxacillin (41.6%), lincomycin (36.6%), gentamicin

(35.0%), ampicillin ( 30.0%), while in our study the identified microflora turned out to be sensitive

to ciproflaxacin (ciprocor, cyprinol) – 86.7%, penfloxacin (abactal) - 84.3%, cefazolin (kefzol) -

82.3%, ceftazidime (Fortum) - 82.9%, cefuraxime (zinacef) - 81.7%, cefotaxime (clofaran) -

76.6%, ceftriaxone - 71.9%, gentamicin - 62.6%, ampicillin - 51.7%.

At the same time, it was revealed that 21.6% of strains were sensitive to one of the tested

687

ResearchBib IF-2023: 11.01, ISSN: 3030-3753, Valume 1 Issue 10

antibiotics, 10.6% to two, 5.7% to three, 5.7% to four, 12.2% to five. , to six – 7.4% and to the rest

– from 2.2 to 9.6%.

Studies have shown that the resistance of fungi to antifungal drugs has sharply increased.

Thus, the greatest sensitivity remains to 5-NOK - in 80.9% of cases, gentian violet - in 85.6%,

nystatin sensitivity decreased to 61%, nizoral, levorin, fargals - sensitivity decreased and ranged

from 24% to 33%, and to Diflucan and Mycosist - from 16 to 42%.

Thus, our observations indicate variability in the microbiocenosis of the genital organs,

both in infectious agents and in the bacteriogram, which is apparently associated with irrational

antibiotic therapy, without determining the type of causative agent of their sensitivity and taking

into account the pharmacodynamics and pharmacokinetics of prescribed antibiotics and

antimycotic drugs.

Conclusions:

Thus, we can conclude that the leading cause of undeveloped pregnancy is

the combination of an STI with a bacterial viral infection.

REFERENCES

1.

Rajabova Oygul Islomovna.(2024). VIRUSLI GEPATITLAR VA TUG‘RUQDAN

KEYINGI

ERTA

QON

KETISHLARNI

KAMAYTIRISHNING

YANGI

TEXNOLOGIYALARI. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В

МИРЕ, 39(5), 99–106.

https://www.newjournal.org/index.php/01/article/view/11723

2.

Rajabova Oygul Islomovna .(2024). A Comparative Analysis of the Effectiveness of

Vaginal Progesterone, Cervical Pesar, and Their Combination for Preventing the Risk of

Premature Labor in High-Risk Pregnant Women BEST JOURNAL OF INNOVATION IN

SCIENCE,

RESEARCH

AND

DEVELOPMENT,

3(3),

440-446.

http://www.bjisrd.com/index.php/bjisrd/article/view/1849/1700

3.

Rajabova Oygul Islomovna.(2024). MODERN CONCEPT OF RECURRENT VAGINAL

INFECTIONS

IN WOMEN OF REPRODUCTIVE AGE, 3(04), 128-131.

https://jhlsr.innovascience.uz/index.php/jhlsr/article/view/518/455

4.

Rajabova Oygul Islomovna.(2024).

METHODS OF PHARMACOTHERAPEUTIC

TREATMENT OF ABNORMAL UTERINE BLEEDING IN GIRLS, 3(5),193-197

https://mudarrisziyo.uz/index.php/pedagogika/article/view/945

5.

Rajabova Oygul Islomovna.(2024).

Method Stopping Atonic Bleeding From the Uterus

after Childbirth Using Balloon Tamponade

International Journal of Alternative and

Contemporary Therapy with U.S. ISSN 2995-5378

In Volume 2, Issue 9 (2024)

https://medicaljournals.eu/index.php/IJACT/article/view/965

688

ResearchBib IF-2023: 11.01, ISSN: 3030-3753, Valume 1 Issue 10

6.

Rajabova Oygul Islomovna.(2024).

Tactics for carrying women at high risk of recurrent

miscarriage.

New renaissance journal ResearchBib IF-2023: 11.01, ISSN: 3030-3753,

Valume 1 Issue 8 Pp:509-514

https://doi.org/10.5281/zenodo.13982730

7.

Farida Farkhodovna, K. ., Umida Rakhmatulloevna, N. ., & Mokhigul Abdurasulovna, B.

(2022). ETIOLOGY OF CHRONIC RHINOSINUSITIS AND EFFECTIVENESS OF

ETIOTROPIC TREATMENT METHODS (LITERATURE REVIEW). Новости

образования: исследование в XXI веке, 1(4), 377–381. извлечено от

https://nauchniyimpuls.ru/index.php/noiv/article/view/1367

8.

Numonova,

A.,

&

Narzulayeva,

U.

(2023).

EPIDEMIOLOGY

AND

ETIOPATHOGENESIS OF CHF. Наука и инновация, 1(15), 115-119.

9.

Орипова Озода Олимовна, Самиева Гулноза Уткуровна, Хамидова Фарида

Муиновна, & Нарзулаева Умида Рахматуллаевна (2020). Состояние плотности

распределения лимфоидных клеток слизистой оболочки гортани и проявления

местного иммунитета при хроническом ларингите (анализ секционного материала).

Academy, (4 (55)), 83-86.

10.

Umida Rakhmatulloevna Narzulaeva, & Xamrayeva Muxlisa Farmon qizi. (2023).

ETIOPATHOGENESIS OF HEMOLYTIC ANEMIA. Web of Medicine: Journal of

Medicine,

Practice

and

Nursing,

1(1),

1–4.

Retrieved

from

https://webofjournals.com/index.php/5/article/view/26

11.

Нарзулаева, У., Самиева, Г., & Насирова, Ш. (2023). Гемореологические нарушения

на ранних стадиях гипертензии в жарком климате. Журнал биомедицины и

практики, 1(1), 221–225.

https://doi.org/10.26739/2181 -9300-2021-1-31

12.

Umida Rakhmatulloevna Narzulaeva. (2023). Important Aspects of Etiology And

Pathogenesis of Hemolytic Anemias. American Journal of Pediatric Medicine and Health

Sciences

(2993-2149),

1(7),

179–182.

Retrieved

from

https://grnjournal.us/index.php/AJPMHS/article/view/817

13.

Нарзулаева, У. Р., Самиева, Г. У., & Насирова, Ш. Ш. (2021). ИССИҚ ИҚЛИМДА

КЕЧУВЧИ ГИПЕРТОНИЯ КАСАЛЛИГИНИНГ БОШЛАНҒИЧ БОСҚИЧЛАРИДА

ГЕМОРЕОЛОГИК БУЗИЛИШЛАР. ЖУРНАЛ БИОМЕДИЦИНЫ И ПРАКТИКИ,

6(1).

14.

Нарзулаева, У., Самиева, Г., Лапасова, З., & Таирова, С. (2023). Значение диеты в

лечении артериальной гипертензии . Журнал биомедицины и практики, 1(3/2), 111–

116.

https://doi.org/10.26739/2181-9300-2021-3-98

15.

Narzulaeva Umida Rakhmatulloevna, Samieva Gulnoza Utkurovna, & Ismatova Marguba

Shaukatovna (2020). SPECIFICITY OF THE CLINICAL COURSE OF THE INITIAL

689

ResearchBib IF-2023: 11.01, ISSN: 3030-3753, Valume 1 Issue 10

STAGES OF HYPERTENSION IN ARID ZONES OF UZBEKISTAN AND NON-

DRUG APPROACHES TO TREATMENT. Кронос, (4 (43)), 15-17.

16.

Umida Raxmatulloevna Narzulaeva, & Mohigul Abdurasulovna Bekkulova (2023).

Arterial gipertenziya etiologiyasida dislipidemiyaning xavf omili sifatidagi roli. Science

and Education, 4 (2), 415-419.

17.

Narzulaeva, U. R., & Samieva, G. U. (2021). Nasirova ShSh. Hemoreological Disorders in

The Early Stages Of Hypertension In Hot Climates. Journal of Biomedicine and Practice,

6(1), 221-225.

18.

Dilsora Nuriddinovna Juraeva, Umida Rakhmatulloevna Narzulaeva, & Kurbonova

Gulbahor Aslamovna. (2022). GENDER DIFFERENCES IN THE PARACLINICAL

FEATURES OF THE COURSE OF TRIGEMINAL NEURALGIA. World Bulletin of

Public

Health,

8,

186-190.

Retrieved

from

https://www.scholarexpress.net/index.php/wbph/article/view/751

19.

Narzulaeva, U. (2023). PATHOGENETIC MECHANISMS OF MICROCIRCULATION

DISORDERS. International Bulletin of Medical Sciences and Clinical Research, 3(10),

60–65. Retrieved from

https://researchcitations.com/index.php/ibmscr/article/view/2811

20.

Narzulaeva Umida Rakhmatulloevna and Rakhmatova Fotima Ulugbekovna,

“PATHOGENETIC MECHANISMS OF DISORDERS IN THE HEMOSTASIS

SYSTEM OBSERVED IN PATIENTS INFECTED WITH COVID-19”, IEJRD -

International Multidisciplinary Journal, vol. 7, no. ICMEI, p. 3, Feb. 2023.

21.

Rajabova Oygul Islomovna.(2024). ASSESSMENT OF THE FREQUENCY OF

CAESAREAN SECTION USING ROBSON'S CLASSIFICATION IN MATERNITY

INSTITUTIONS (EXAMPLE OF PERINATAL CENTER OF BUKHARA REGION).

ResearchBib

IF-2023:

11.01,

ISSN:

3030-3753,

Valume

1

Issue

9

https://doi.org/10.5281/zenodo.14182279

22.

Shukurova, S. (2024). Optimizing synergies: Effective strategies for integrating economic

and environmental interests in sustainable development. In E3S Web of Conferences (Vol.

587, p. 04007). EDP Sciences.

23.

Tuyg’unovna, S. S. (2024). MEDICINAL PLANTS THAT ARE WIDELY USED IN

NATURE, RICH IN VITAMINS. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ

ИДЕИ В МИРЕ, 39(3), 242-247.

24.

Tuyg’unovna, S. S. (2024). THE PROCESS OF PACKAGING MEDICINAL PLANTS.

ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 39(3), 248-256.

690

ResearchBib IF-2023: 11.01, ISSN: 3030-3753, Valume 1 Issue 10

25.

Tuyg’unovna, S. S. (2024). ABOUT USEFUL MEDICINAL PLANTS RICH IN LIPIDS

USED IN MEDICINE.

ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В

МИРЕ

,

39

(3), 235-241.

26.

Tuyg’unovna, S. S. (2024). TARKIBIDA EFIR MOYLAR BO’LGAN DORIVOR

O’SIMLIKLAR. TA'LIM VA RIVOJLANISH TAHLILI ONLAYN ILMIY JURNALI,

4(3), 164-167.

27.

Tuyg’unovna, S. S. (2024). MEDICINAL PLANTS CONTAINING ESSENTIAL OILS.

ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 41(4), 62-69.

28.

Tuyg’unovna, S. S. (2024). TARKIBIDA ALKALOIDLAR BO’LGAN DORIVOR

O’SIMLIKLAR. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ,

41(4), 70-77.

29.

Tuyg’unovna, S. S. (2024). CULTIVATION OF MEDICINAL PLANTS AND FORMS

OF PREPARATION. EUROPEAN JOURNAL OF MODERN MEDICINE AND

PRACTICE, 4(5), 71-75.

30.

Tuyg’unovna, S. S. (2024). SYSTEMATIC ANALYSIS OF MEDICINAL

PLANTS.

Лучшие интеллектуальные исследования

,

19

(5), 159-164.

31.

Tuyg’unovna, S. S. (2024). DORIVOR O’SIMLIKLARNING SISTEMATIK TAHLILI.

TA'LIM VA RIVOJLANISH TAHLILI ONLAYN ILMIY JURNALI, 4(4), 180-184.

32.

Tuyg’unovna, S. S. (2024). BAKTERIYALAR GENETIKASI. BAKTERIYALARDA

GENETIK

ALMASHINUV

MIKROORGANIZMLARNING

O

‘ZGARUVCHANLIGI.

MASTERS

,

2

(5), 183-192.