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CLINICAL COURSE AND METHODS OF TREATMENT OF MALIGNANT TUMOR
OF THE SIGMOID COLON
Elyorbek Namozov Ilhom o’g’li
Faculty of Medicine, International University of Asia, Uzbekistan.
https://doi.org/10.5281/zenodo.14706613
Abstract. The most common form of neoplasm of the main part of the large intestine is
sigmoid colon cancer. Originating from the mucous membrane of the intestinal wall, the tumor has
an aggressive clinical course, a high relapse rate and a tendency to early metastasis. Despite all
the advances in the diagnosis and treatment of colorectal pathology, the incidence is steadily
increasing. And only early detection of the tumor process gives a real chance for a complete cure.
Keywords: Types of tumors, causes of their appearance, histological classification,
symptoms, clinical course, treatment methods.
КЛИНИЧЕСКОЕ ТЕЧЕНИЕ И МЕТОДЫ ЛЕЧЕНИЯ ЗЛОКАЧЕСТВЕННОЙ
ОПУХОЛИ СИГМОВИДНОЙ КИШКИ
Аннотация. Наиболее частой формой новообразований основной части толстой
кишки является рак сигмовидной кишки. Возникая из слизистой оболочки стенки кишки,
опухоль отличается агрессивным клиническим течением, высокой частотой рецидивов и
склонностью к раннему метастазированию. Несмотря на все успехи в диагностике и
лечении колоректальной патологии, заболеваемость неуклонно растет. И только раннее
выявление опухолевого процесса дает реальный шанс на полное излечение.
Ключевые слова: Виды опухолей, причины их появления, гистологическая
классификация, симптомы, клиническое течение, методы лечения.
The sigmoid colon owes its name to its S-shape. It is the final section of the colon,
responsible for the absorption of water and the formation of feces. Originating in the area of the
upper opening of the small pelvis, the sigma is directed transversely to the right, then to the left
and, at the level of the third sacral vertebra, passes into the final (rectal) section of the digestive
tract.
Sigmoid colon cancer is a malignant neoplasm of epithelial origin, accounting for 44% of
the total number of colorectal tumors. The incidence rate increases after forty years and is mainly
registered in elderly people. In men, oncopathology of this localization occurs 1.2 times more often
than in women.
The most vulnerable population to the process of malignancy are:
• patients suffering from genetic diseases (Lynch syndrome);
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• persons with a family history (familial adenomatosis, MutYH-associated colon
polyposis).
The leading risk factors for sporadic cases of the disease include:
• chronic inflammation in the large intestine;
• diabetes mellitus;
• smoking, excessive alcohol consumption;
• physical inactivity;
• predominance of red meat in the diet.
Depending on the cellular structure of the tumor, the following forms of sigmoid colon
cancer are distinguished:
• congenital nonpolyposis (Lynch syndrome);
• adenogenic (without clear morphological signs);
• mucous adenocracionoma (various variants);
• micropapillary carcinoma;
• signet cell carcinoma.
Malignant neoplasms of sigma are low, moderate and highly differentiated. Tumors
growing inside the intestinal lumen are called exophytic; tumors growing into the intestinal wall
are called endophytic (infiltrative).
Sigmoid colon cancer at the initial stage is asymptomatic and is detected only during a
special examination. The first signs appear when the process has gone far enough, the tumor has
already acquired large sizes and extends beyond the intestine. All symptoms of sigmoid colon
cancer can be divided into two large groups - general and local. Common symptoms include:
• Weight loss not related to diets and sports activities - a decrease in div weight by more
than 10% within six months.
• Anemia - pallor of the skin and mucous membranes, pasty tissue, deterioration in the
quality of hair and nails.
• Fatigue, decreased performance, etc.
The oncology center provides comprehensive treatment for sigmoid colon cancer,
consisting of surgery, chemotherapy and radiation therapy. The central method in this case is
surgical intervention. Without surgery, other methods will not be able to overcome the disease.
Surgical intervention is based on the initial removal of infected tissue, further removal of
areas affected by metastases and subsequent restoration of the integrity of the intestinal tube. For
small tumors, the operation is performed using laparotomy, based on several punctures.
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In advanced stages of sigmoid colon cancer, treatment by surgery involves complete
removal of the sigmoid colon and removal of the gas tube during the postoperative period. After a
few months, if the operation is successful, stool will be passed through the usual route.
Chemotherapy is a drug treatment. It is based on the introduction of special chemicals, the
action of which is aimed at destroying the affected tissues and reducing the activity of tumor cells
to divide. The method is used both before and after surgery to consolidate the effect of
surgery.There are mono- and polychemotherapy. Its effect is aimed at reducing tumor size,
preventing relapses and inhibiting the progression of the disease.
Radiation therapy for sigmoid colon cancer is used with extreme caution, due to the risk of
developing perforation of the intestinal walls. In addition, it has a weak effect on intestinal
oncology. The positive effect is the destruction of cancerous tissue in the area between the excised
material and healthy tissue.
REFERENCES
1.
Saodat, A., Vohid, A., Ravshan, N., & Shamshod, A. (2020). MRI study in patients with
idiopathic cokearthrosis of the hip joint.
International Journal of Psychosocial
Rehabilitation
,
24
(2), 410-415.
2.
Axmedov, S. J. (2023). EFFECTS OF THE DRUG MILDRONATE.
Innovative Development
in Educational Activities
,
2
(20), 40-59.
3.
Jamshidovich, A. S.
(2023). ASCORBIC ACID: ITS ROLE IN IMMUNE SYSTEM, CHRONIC
INFLAMMATION DISEASES AND ON THE ANTIOXIDANT EFFECTS.
EUROPEAN JOURNAL
OF MODERN MEDICINE AND PRACTICE
,
3
(11), 57-60.
4.
Jamshidovich, A. S. (2023). THE ROLE OF THIOTRIAZOLINE IN THE
ORGANISM.
Ta'lim innovatsiyasi va integratsiyasi
,
9
(5), 152-155.
5.
Jamshidovich, A. S. (2023). HEPTRAL IS USED IN LIVER DISEASES.
ОБРАЗОВАНИЕ
НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ
,
35
(3), 76-78.
6.
Jamshidovich, A. S. (2023). EFFECT OF TIVORTIN ON CARDIOMYOCYTE CELLS AND
ITS ROLE IN MYOCARDIAL INFARCTION.
Gospodarka i Innowacje.
,
42
, 255-257.
7.
Jamshidovich, A. S. (2024). NEUROPROTECTIVE EFFECT OF CITICOLINE.
EUROPEAN
JOURNAL OF MODERN MEDICINE AND PRACTICE
,
4
(1), 1-4.
8.
Jamshidovich, A. S. (2024). THE ROLE OF TRIMETAZIDINE IN ISCHEMIC
CARDIOMYOPATHY.
Journal of new century innovations
,
44
(2), 3-8.
9.
Jamshidovich,
A.
S.
(2024).
ВСЕ
ЭФФЕКТЫ
ПРЕПАРАТА
ИМУДОН.
TADQIQOTLAR
,
31
(2), 39-43.
654
ResearchBib IF - 11.01, ISSN: 3030-3753, Valume 2 Issue 1
10.
Jamshidovich, A. S. (2024). SPECIFIC FEATURES OF THE EFFECT OF THE HEPARIN
DRUG.
TADQIQOTLAR
,
31
(2), 34-38.
11.
Jamshidovich, A. S. (2024). ЭФФЕКТИВНОЕ ВОЗДЕЙСТВИЕ ПРЕПАРАТА
КЕЙВЕР.
Ta'lim innovatsiyasi va integratsiyasi
,
15
(3), 137-143.
12.
Namozov, E. (2024). KЛИНИКО-МОРФОЛОГИЧЕСКИЕ ФОРМЫ РАКА МОЧЕВОГО
ПУЗЫРЯ.
Modern Science and Research
,
3
(12), 911-914.
13.
Namozov, E. (2024). OПУХОЛИ ПОЧЕК.
Modern Science and Research
,
3
(11), 884-886.
14.
Namozov, E. (2024). PRECANCEROUS DISEASES OF THE STOMACH.
Modern Science
and Research
,
3
(10), 506-508.
15.
Gafurovna, A. N., Xalimovich, M. N., & Komilovich,
E. B. Z. (2023). KLIMAKTERIK
YOSHDAGI AYOLLARDA ARTERIAL GIPERTENZIYANING KECHISHI.
ОБРАЗОВАНИЕ
НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ
,
23
(6), 26-31.
16.
Komilovich, E. B. Z. (2023). Coronary Artery Disease.
EUROPEAN JOURNAL OF MODERN
MEDICINE AND PRACTICE
,
3
(12), 81-87.
17.
Эргашов, Б. К. (2023). Артериальная Гипертония: Современный Взгляд На
Проблему.
Research Journal of Trauma and Disability Studies
,
2
(11), 250-261.
18.
Эргашов, Б. К., & Мавлонов, Н. Х.
(2024). ГИПЕРТОНИЧЕСКАЯ БОЛЕЗНЬ
ЛЕЧЕНИЕ.
ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ
,
38
(7), 243-250.
19.
Komilovich, E. B. (2024). HYPERTENSION TREATMENT.
ОБРАЗОВАНИЕ НАУКА И
ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ
,
38
(7), 227-234.
20.
Komilovich, E. B. (2024). CORONARY HEART DISEASE. ANGINA EMERGENCY
CARE.
ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ
,
38
(7), 235-242.
21.
Jamshidovich, A. S., & Komilovich, E. B. (2024). THE IMPORTANCE OF THE DRUG
ALLOCHOL
FOR
CHRONIC
CHOLECYSTITIS.
Ta'lim
innovatsiyasi
va
integratsiyasi
,
14
(2), 133-137.
22.
Jamshidovich, A. S., & Komilovich, E. B. (2024). ВАЖНЫЕ СВОЙСТВА ПРЕПАРАТА ДЕ-
НОЛ (субцитрат висмута).
Ta'lim innovatsiyasi va integratsiyasi
,
14
(2), 143-147.
23.
Jamshidovich, A. S., & Komilovich, E. B. (2024). SPECIAL FEATURES OF BUDECTON
DRUG.
Ta'lim innovatsiyasi va integratsiyasi
,
14
(2), 138-142.
24.
Jamshidovich, A. S., & Komilovich, E. B. (2024). IMMUNOMODULATORY FUNCTION
OF DIBAZOL DRUG.
ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В
МИРЕ
,
38
(5), 83-87.
25.
Jamshidovich, A. S., & Komilovich, E. B.
(2024). ADVANTAGES OF THE DRUG
HEPTRAL.
ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ
,
38
(5), 98-101.
655
ResearchBib IF - 11.01, ISSN: 3030-3753, Valume 2 Issue 1
26.
Komilovich, E. B., & Jamshidovich, A. S. (2024). YURAK ISHEMIYASI.
STENOKARDIYADA SHOSHILINCH TIBBIY YORDAM.
ОБРАЗОВАНИЕ НАУКА И
ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ
,
38
(6), 12-20.
27.
Эргашов, Б. К., & Ахмедов, Ш. Ж. (2024). ГИПЕРТОНИЧЕСКАЯ БОЛЕЗНЬ
ЭТИОЛОГИЯ.
ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ
,
38
(6),
59-69.
28.
Эргашов,
Б.
К.
(2024).
ГИПЕРТОНИЧЕСКАЯ
БОЛЕЗНЬ
ДИАГНОСТИКА.
ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В
МИРЕ
,
38
(6), 70-78.
29.
Эргашов, Б. К. (2024). ИШЕМИЧЕСКАЯ БОЛЕЗНЬ СЕРДЦА. СТЕНОКАРДИЯ
ПРОФИЛАКТИКА.
ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В
МИРЕ
,
38
(6), 21-31.
