Authors

  • Shamshod Axmedov

DOI:

https://doi.org/10.71337/inlibrary.uz.science-research.71451

Keywords:

Moxonidine (Fisiotens®) α2 –adrenoreceptors atherogenic dyslipidemia arterial hypertension metabolic syndrome imidazoline I1 –receptors catecholamine.

Abstract

Moxonidine (Fisiotens®) is an antihypertensive drug that selectively interacts with imidazoline I1-receptors located in the brainstem, resulting in a decrease in sympathetic activity and blood pressure (BP). Moxonidine (Fisiotens®) has high affinity to imidazoline I1 -receptors and only slightly binds to central α2 -adrenoreceptors, due to interaction with which dry mouth and sedative effect are mediated; reduces tissue resistance to insulin. Decrease in systolic and diastolic BP at a single and prolonged administration of the drug is associated with a decrease in the pressor action of the sympathetic nervous system on peripheral vessels, reduction of total peripheral resistance (TPR).

background image

350

ResearchBib IF - 11.01, ISSN: 3030-3753, Volume 2 Issue 3

THE DRUG PHYSIOTENS, THE FEATURES OF THE DRUG AND ITS USE IN THE

FIELD OF CARDIOLOGY, IN PATIENTS WITH HEAVY BODY WEIGHT

Axmedov Shamshod Jamshidovich

Faculty of Medicine, International University of Asia, Uzbekistan.

https://doi.org/10.5281/zenodo.15002529

Abstract.

Moxonidine (Fisiotens®) is an antihypertensive drug that selectively interacts

with imidazoline I1-receptors located in the brainstem, resulting in a decrease in sympathetic

activity and blood pressure (BP). Moxonidine (Fisiotens®) has high affinity to imidazoline I1 -

receptors and only slightly binds to central α2 -adrenoreceptors, due to interaction with which

dry mouth and sedative effect are mediated; reduces tissue resistance to insulin. Decrease in

systolic and diastolic BP at a single and prolonged administration of the drug is associated with

a decrease in the pressor action of the sympathetic nervous system on peripheral vessels,

reduction of total peripheral resistance (TPR).

Keywords:

Moxonidine (Fisiotens®), α2 –adrenoreceptors, atherogenic dyslipidemia,

arterial hypertension, metabolic syndrome, imidazoline I1 –receptors, catecholamine.

ПРЕПАРАТ ФИЗИОТЕНЗ, ОСОБЕННОСТИ ПРЕПАРАТА И ЕГО ПРИМЕНЕНИЕ

В ОБЛАСТИ КАРДИОЛОГИИ, У ПАЦИЕНТОВ С БОЛЬШОЙ МАССОЙ ТЕЛА

Аннотация.

Моксонидин (Физиотенз®) — антигипертензивный препарат,

селективно взаимодействующий с имидазолиновыми I1-рецепторами, расположенными в

стволе головного мозга, что приводит к снижению симпатической активности и

артериального давления (АД). Моксонидин (Физиотенз®) обладает высоким сродством к

имидазолиновым I1-рецепторам и лишь в незначительной степени связывается с

центральными α2-адренорецепторами, за счет взаимодействия с которыми

опосредуются сухость во рту и седативный эффект; снижает резистентность тканей

к инсулину. Снижение систолического и диастолического АД при однократном и

длительном введении препарата связано с уменьшением прессорного действия

симпатической нервной системы на периферические сосуды, уменьшением общего

периферического сопротивления (ОПС).

Ключевые слова:

Моксонидин (Физиотенз®), α2 –адренорецепторы, атерогенная

дислипидемия, артериальная гипертензия, метаболический синдром, имидазолиновые I1 –

рецепторы, катехоламины.

Metabolic syndrome (MS) as a set of metabolic disorders and associated pathological

manifestations (atherogenic dyslipidemia, insulin resistance, hypersympathicotonia, arterial

hypertension, abdominal obesity, endothelial dysfunction, increased blood coagulation


background image

351

ResearchBib IF - 11.01, ISSN: 3030-3753, Volume 2 Issue 3

properties) are recognised as risk factors for the development of atherosclerotic diseases and

cardiovascular mortality [1, 2]. The prevalence of MS in the adult population reaches 23-24%,

and at the age of up to 49 years it is more often detected in men, and at the age of over 70 years -

in women [3, 4]. These observations gave grounds to consider, along with other factors, the role

of menopause in the development of MS. menopause in the development of MS. In 1997

menopausal metabolic syndrome (MMS) was singled out. metabolic syndrome (MMS) as a type

of MS, the development of which is based on estrogen deficiency [5, 6].

The aim of the study:

-to study the effect of long-term use of moxonidine (Physiotez) on arterial hypertension,

lipid and carbohydrate metabolism, autonomic dysfunction, psychoemotional status - on risk

factors of atherosclerotic diseases in women with MS. The results of observation of 32 women

aged from 45 to 68 years (58.3.3 years) were analysed. 45 to 68 years (58.3±2.3 years), suffering

from mild and moderate arterial hypertension (AH) stage II in combination with MMC. The

mean duration of AH was 8.2±1.4 years. All women had manifestations of menopausal

syndrome. Prior to the study, the patients did not receive hypotensive drugs for a week,

anthropometric measurements, clinical examination, office BP determination (according to

Korotkov) were performed. BP determination (according to Korotkov), electrocardiography,

bicycle ergometry, biochemical tests: total cholesterol (TC), high-density lipid cholesterol

(HDL) and low-density lipid cholesterol (HDL), triglycerides, fasting and post-exercise blood

glucose. fasting blood glucose and after a 75 g glucose load [8]. The Weyl index was used to

assess the state of the autonomic nervous system. The severity of menopausal syndrome (MS)

was determined by the Kupperman index based on the vasomotor and general reactions (the

number of ‘hot flashes’, their severity, sweating, etc.).

Our observations have shown a good hypotensive effect of M, that is consistent with the

data of other studies conducted both in women with estrogen deficiency [9,10] and in mixed

groups where the hormonal factor was not taken into account [11-15] . The mechanism of

hypotension is associated with a decrease in sympathoadrenal hyperactivity, secretion of

catecholamines, renin, aldosterone, and a decrease in peripheral arterial tone [6, 16]. The

efficacy of M in the treatment of AH is comparable to that of modern first-line antihypertensive

drugs (IAPP, beta-adrenoreceptor blockers and calcium channel blockers) [18, 19], regardless of

the level of estrogenic activity.

At the same time, positive dynamics of the general condition of women was observed

during M treatment. Along with normalisation of BP and disappearance of clinical

manifestations of hypertension, the severity of menopausal syndrome decreased significantly: the

frequency of ‘hot flashes’, intensity of sweating, headache, cardialgia stopped, psychoemotional


background image

352

ResearchBib IF - 11.01, ISSN: 3030-3753, Volume 2 Issue 3

status improved. The number of women with mild course of CS increased from 10 to 21 (at the

expense of more severe forms), Kupperman index decreased from 33.8±1.2 to 22.4±1.1

(P<0.05). The manifestations of autonomic dysfunction decreased - Weyl index decreased from

43.3±2.2 to 26.1±0.9 (P<0.05).

The quality of life’ improved by 1.28 points (P<0.05). The favourable effect of M on the

course of menopause, general condition, emotional sphere and standard of living of patients

deserves special attention, which allows to give preference to imidazoline receptor agonists when

building a treatment programme for menopausal women to achieve a better result.

Conclusions

Moxonidine has provided a vector for speculation about the possible link between

hypertension, overweight and stress. My personal experience of using the drug shows that I have

no objections to the hypotensive effect of moxonidine, the dose of 0.2 mg is rarely used, I

prescribe immediately 0.4-0.6mg/day. Studies indicate the benefits of moxonidine in the

treatment of AH in overweight. In our national guidelines from the WNOC, 2004, the

moxonidine class is indicated for the treatment of AH in MS and diabetes mellitus (DM). In the

recommendations of the European Society of Hypertension ESH, 2003, as recommendations for

the therapy of patients with RAS hyperactivity, MS and DM (called the most rational

combinations of two or more hypotensive drugs).

- The imidazoline receptor agonist moxonidine (Fisiotenz) in the 6-month treatment of

menopausal women with metabolic syndrome reduces total metabolic syndrome. syndrome

reduces the total risk of cardiovascular diseases due to normalisation of BP (in 81,2% of

patients), positive effect on lipid and carbohydrate metabolism (increase of HDL cholesterol by

15%, decrease of glycaemia in 2 hours after glucose load by 17,48%), reduction of autonomic

dysfunction.

- Moxonidine (Physiotensis) favourably affects the course of menopausal syndrome,

improves the quality of life of patients.

- In the course of long-term treatment moxonidine (Physiotenz) is well well tolerated by

84.4% and satisfactory - 15.6% of patients.

REFERENCES

1.

Saodat, A., Vohid, A., Ravshan, N., & Shamshod, A. (2020). MRI study in patients with

idiopathic cokearthrosis of the hip joint.

International Journal of Psychosocial

Rehabilitation

,

24

(2), 410-415.

2.

Axmedov, S. J. (2023). EFFECTS OF THE DRUG MILDRONATE.

Innovative

Development in Educational Activities

,

2

(20), 40-59.


background image

353

ResearchBib IF - 11.01, ISSN: 3030-3753, Volume 2 Issue 3

3.

Jamshidovich, A. S. (2023).

ASCORBIC ACID: ITS ROLE IN IMMUNE SYSTEM,

CHRONIC

INFLAMMATION

DISEASES

AND

ON

THE

ANTIOXIDANT

EFFECTS.

EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE

,

3

(11),

57-60.

4.

Jamshidovich, A. S. (2023). THE ROLE OF THIOTRIAZOLINE IN THE

ORGANISM.

Ta'lim innovatsiyasi va integratsiyasi

,

9

(5), 152-155.

5.

Jamshidovich,

A. S. (2023). HEPTRAL IS USED IN LIVER DISEASES.

ОБРАЗОВАНИЕ

НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ

,

35

(3), 76-78.

6.

Jamshidovich, A. S. (2023).

EFFECT OF TIVORTIN ON CARDIOMYOCYTE CELLS AND

ITS ROLE IN MYOCARDIAL INFARCTION.

Gospodarka i Innowacje.

,

42

, 255-257.

7.

Jamshidovich, A. S. (2024).

NEUROPROTECTIVE EFFECT OF CITICOLINE.

EUROPEAN

JOURNAL OF MODERN MEDICINE AND PRACTICE

,

4

(1), 1-4.

8.

Jamshidovich, A. S. (2024). THE ROLE OF TRIMETAZIDINE IN ISCHEMIC

CARDIOMYOPATHY.

Journal of new century innovations

,

44

(2), 3-8.

9.

Jamshidovich,

A.

S.

(2024).

ВСЕ

ЭФФЕКТЫ

ПРЕПАРАТА

ИМУДОН.

TADQIQOTLAR

,

31

(2), 39-43.

10.

Jamshidovich, A. S. (2024). SPECIFIC FEATURES OF THE EFFECT OF THE

HEPARIN DRUG.

TADQIQOTLAR

,

31

(2), 34-38.

11.

Jamshidovich, A. S. (2024). USE OF GLUCOCORTICOSTEROIDS IN PEDIATRIC

PRACTICE.

TADQIQOTLAR

,

31

(2), 29-33.

12.

Jamshidovich,

A.

S.

(2024).

РОЛЬ

ИНТЕЛЛАНОВОГО

СИРОПА

И

ЦИАНОКОБАЛАМИНА В УЛУЧШЕНИИ ПАМЯТИ.

TADQIQOTLAR

,

31

(2), 44-48.

13.

Jamshidovich, A. S. (2024). TREATMENT OF POLYNEUROPATHY WITH

BERLITHION.

Ta'limning zamonaviy transformatsiyasi

,

4

(1), 201-209.

14.

Jamshidovich, A. S. (2024). USE OF ASCORIL IN BRONCHIAL ASTHMA.

Ta'limning

zamonaviy transformatsiyasi

,

4

(1), 191-200.

15.

Jamshidovich,

A.

S.

(2024).

THE

IMPORTANCE

OF

THE

DRUG

ARTOXAN.

Ta'limning zamonaviy transformatsiyasi

,

4

(1), 182-190.

16.

Jamshidovich, A. S. (2024). THE ROLE OF RENGALIN IN CHRONIC

BRONCHITIS.

ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В

МИРЕ

,

38

(4), 116-123.

17.

Jamshidovich, A. S. (2024). THE ROLE OF ALMAGEL DRUG IN GASTRIC AND

DUODENAL WOUND DISEASE.

Ta'limning zamonaviy transformatsiyasi

,

4

(1), 173-

181.


background image

354

ResearchBib IF - 11.01, ISSN: 3030-3753, Volume 2 Issue 3

18.

Jamshidovich, A. S. (2024). THE ROLE OF CODELAK BRONCHO SYRUP IN

CHILDREN'S PRACTICE.

ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В

МИРЕ

,

38

(4), 109-115.

19.

Jamshidovich, A. S. (2024). THE AEVIT DRUG EFFECT.

ОБРАЗОВАНИЕ НАУКА И

ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ

,

38

(4), 124-132.

20.

Jamshidovich, A. S. (2024). THE IMPORTANCE OF ALCHEBA DRUG IN POST-

STROKE APHASIA.

ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В

МИРЕ

,

38

(4), 132-138.

21.

Jamshidovich, A. S. (2024). THE ROLE OF HYALURON CHONDRO DRUG IN

OSTEOARTHROSIS.

ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В

МИРЕ

,

38

(4), 139-145.

22.

Jamshidovich,

A.

S.

(2024).

EFFECT

OF

SIMETHICONE

DROP

IN

FLATULENCE.

Лучшие интеллектуальные исследования

,

14

(1), 95-101.

23.

Jamshidovich, A. S. (2024). BENEFITS OF BETADINE SOLUTION.

Лучшие

интеллектуальные исследования

,

14

(1), 116-122.

24.

Jamshidovich, A. S. (2024). EFFECT INHALED GLUCOCORTICOIDS IN CHRONIC

OBSTRUCTIVE

PULMONARY

DISEASE

AND

BRONCHIAL

ASTHMA.

TADQIQOTLAR

,

31

(1), 171-180.

25.

Jamshidovich, A. S. (2024). USE OF VIGANTOL IN RICKETS.

Лучшие

интеллектуальные исследования

,

14

(1), 102-108.

26.

Jamshidovich, A. S. (2024). THE VITAPROST DRUG RESULTS.

Лучшие

интеллектуальные исследования

,

14

(1), 109-115.

27.

Jamshidovich, A. S. (2024). THE ROLE OF BISEPTOL DRUG IN URINARY TRACT

DISEASE.

Лучшие интеллектуальные исследования

,

14

(1), 89-94.

28.

Jamshidovich,

A.

S.

(2024).

PROPERTIES

OF

THE

DRUG

DORMIKIND.

ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В

МИРЕ

,

38

(5), 88-92.

29.

Jamshidovich, A. S., & Komilovich, E. B. (2024). IMMUNOMODULATORY

FUNCTION OF DIBAZOL DRUG.

ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ

ИДЕИ В МИРЕ

,

38

(5), 83-87.

30.

Jamshidovich, A. S., & Komilovich, E. B. (2024). ADVANTAGES OF THE DRUG

HEPTRAL.

ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ

,

38

(5),

98-101.


background image

355

ResearchBib IF - 11.01, ISSN: 3030-3753, Volume 2 Issue 3

31.

Эргашов, Б. К., & Ахмедов, Ш. Ж. (2024). ГИПЕРТОНИЧЕСКАЯ БОЛЕЗНЬ

ЭТИОЛОГИЯ.

ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В

МИРЕ

,

38

(6), 59-69.

32.

Komilovich, E. B., & Jamshidovich, A. S. (2024). HYPERTENSION, CLASSIFICATION

AND PATHOGENESIS.

ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В

МИРЕ

,

38

(6), 50-58.

33.

Komilovich, E. B., & Jamshidovich, A. S. (2024). YURAK ISHEMIYASI.

STENOKARDIYADA SHOSHILINCH TIBBIY YORDAM.

ОБРАЗОВАНИЕ НАУКА И

ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ

,

38

(6), 12-20.

34.

Komilovich,

E.

B.,

&

Jamshidovich,

A.

S.

(2024).

HYPERTENSION

ETIOLOGY.

ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ

,

38

(6),

32-41.

35.

Komilovich, E. B., & Jamshidovich, A. S. (2024). CARDIAC ISCHEMIA. ANGINA

NURSING DIAGNOSIS AND CARE.

Journal of new century innovations

,

46

(1), 44-52.

36.

Jamshidovich, A. S. (2024). IMPORTANT INDICATIONS OF THE DRUG

WOBENZYM.

Journal of new century innovations

,

46

(1), 29-32.

37.

Jamshidovich, A. S. (2024). THE RESULTS OF THE EFFECT OF THE DRUG

VALIDOL.

Journal of new century innovations

,

46

(1), 19-23.

38.

Jamshidovich, A. S. (2024). VIFERON USE IN CHILDREN.

Journal of new century

innovations

,

46

(1), 24-28.

39.

Jamshidovich,

A.

S.

(2024).

USE

OF

DUSPATALIN

(MEBEVERINE

HYDROCHLORIDE) IN GASTROINTESTINAL DISEASES.

ОБРАЗОВАНИЕ НАУКА

И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ

,

38

(5), 93-97.

40.

Jamshidovich, A. S. (2024). ЭФФЕКТЫ СИРОПА ДЕПАКИНА (ВАЛЬПРОЕВАЯ

КИСЛОТА).

Ta'lim innovatsiyasi va integratsiyasi

,

14

(2), 148-152.

41.

Jamshidovich, A. S., & Komilovich, E. B. (2024). THE IMPORTANCE OF THE DRUG

ALLOCHOL

FOR

CHRONIC

CHOLECYSTITIS.

Ta'lim

innovatsiyasi

va

integratsiyasi

,

14

(2), 133-137.

42.

Jamshidovich, A. S., & Komilovich, E. B. (2024). ВАЖНЫЕ СВОЙСТВА

ПРЕПАРАТА

ДЕ-НОЛ

(субцитрат

висмута).

Ta'lim

innovatsiyasi

va

integratsiyasi

,

14

(2), 143-147.

43.

Jamshidovich, A. S., & Komilovich, E. B. (2024). SPECIAL FEATURES OF

BUDECTON DRUG.

Ta'lim innovatsiyasi va integratsiyasi

,

14

(2), 138-142.

44.

Jamshidovich, A. S. (2024). ЭФФЕКТИВНОЕ ВОЗДЕЙСТВИЕ ПРЕПАРАТА

КЕЙВЕР.

Ta'lim innovatsiyasi va integratsiyasi

,

15

(3), 137-143.


background image

356

ResearchBib IF - 11.01, ISSN: 3030-3753, Volume 2 Issue 3

45.

Jamshidovich, A. S. (2024). USEFUL PROPERTIES OF THE DRUG YODOFOL.

Ta'lim

innovatsiyasi va integratsiyasi

,

15

(3), 144-149.

46.

Jamshidovich, A. S. (2024). FITOTERAPIYANING AKUSHER-GINEKOLOGIYADA

AHAMIYATI.

Лучшие интеллектуальные исследования

,

15

(2), 121-125.

47.

Jamshidovich, A. S. (2024). THE IMPORTANCE OF THE DRUG DOPROKIN.

Лучшие

интеллектуальные исследования

,

15

(2), 109-114.

48.

Jamshidovich, A. S. (2024). THE EFFECT OF DOSTINEX ON THE BODY.

Лучшие

интеллектуальные исследования

,

15

(2), 115-120.

49.

Jamshidovich, A. S. (2024). РЕЗУЛЬТАТЫ ЭФФЕКТИВНОГО ДЕЙСТВИЯ

ПРЕПАРАТА КАНЕФРОН.

Лучшие интеллектуальные исследования

,

15

(2), 138-143.

50.

Jamshidovich,

A.

S.

(2024). СОВРЕМЕННЫЕ ЭФФЕКТЫ ПРЕПАРАТА

ИНДОЛ.

Лучшие интеллектуальные исследования

,

15

(2), 126-131.

51.

Jamshidovich, A. S. (2024). EFFECT OF ISMIZHEN DRUG ON BODY

IMMUNITY.

Лучшие интеллектуальные исследования

,

15

(2), 132-137.

52.

Jamshidovich, A. S. (2024). POSITIVE EFFECTS OF THE DRUG CARCIL.

Ta'lim

innovatsiyasi va integratsiyasi

,

15

(3), 127-131.

53.

Jamshidovich, A. S. (2024). PЕЗУЛЬТАТЫ ЭФФЕКТИВНОГО ДЕЙСТВИЯ

KАВИНТОНА.

Ta'lim innovatsiyasi va integratsiyasi

,

15

(3), 132-136.

54.

Jamshidovich, A. S. (2024). Современный Эффект Спрея Мометазон.

Research Journal

of Trauma and Disability Studies

,

3

(3), 62-65.

55.

Jamshidovich, A. S. (2024). THE ROLE OF" SIMONTE PLUS" DRUG IN THE

MODERN TREATMENT OF BRONCHIAL ASTHMA.

EUROPEAN JOURNAL OF

MODERN MEDICINE AND PRACTICE

,

4

(5), 66-70.

56.

Jamshidovich, A. S. (2024). FEATURES OF THE BIOMECHANISM OF THE DRUG

LEVOMYCETIN (CHLORAMPHENICOL).

EUROPEAN JOURNAL OF MODERN

MEDICINE AND PRACTICE

,

4

(9), 298-301.

57.

Jamshidovich, A. S. (2024). THE MOST IMPORTANT INDICATORS OF OMEGA 3

SUBSTANCE IN THE METABOLISM OF THE HUMAN BODY.

EUROPEAN

JOURNAL OF MODERN MEDICINE AND PRACTICE

,

4

(10), 113-117.

58.

Komilovich, E. B., & Khalimovich,

M. N. (2024). CARDIAC ISCHEMIA. ANGINA

CLINICAL FORMS AND DIAGNOSIS.

Journal of new century innovations

,

46

(1), 70-78.

59.

Komilovich, E. B. (2024).

CORONARY HEART DISEASE. ANGINA EMERGENCY

CARE.

ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ

,

38

(7), 235-242.


background image

357

ResearchBib IF - 11.01, ISSN: 3030-3753, Volume 2 Issue 3

60.

Komilovich, E. B. (2024). YURAK ISHEMIK KASALLIGI. STENOKARDIYANI

DAVOLASHNING ZAMONAVIY TAMOYILLARI.

ОБРАЗОВАНИЕ НАУКА И

ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ

,

38

(6), 3-11.

61.

Jamshidovich, A. S. (2024). THE MOST IMPORTANT BENEFITS OF GINGER FOR

THE HUMAN BODY'S IMMUNITY.

EUROPEAN JOURNAL OF MODERN MEDICINE

AND PRACTICE

,

4

(11), 269-273.

62.

Axmedov, S. (2024). THE SPECIFIC EFFECT OF THE DRUG" BAKLASAN" IN

CEREBROVASCULAR

DISEASES

AND

ITS

PRACTICAL

SIGNIFICANCE

TODAY.

Modern Science and Research

,

3

(12), 485-492.

63.

Komilovich, E. B. Z. (2023). Coronary Artery Disease.

EUROPEAN JOURNAL OF

MODERN MEDICINE AND PRACTICE

,

3

(12), 81-87.

64.

Komilovich,

E.

B.

(2024).

CORONARY

HEART

DISEASE.

ANGINA

TREATMENT.

Journal of new century innovations

,

46

(1), 95-104.

65.

Komilovich, E. B. (2024). HYPERTENSION TREATMENT.

ОБРАЗОВАНИЕ НАУКА

И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ

,

38

(7), 227-234.

66.

Эргашов, Б. К. (2024). ИШЕМИЧЕСКАЯ БОЛЕЗНЬ СЕРДЦА. СТЕНОКАРДИЯ

ПРОФИЛАКТИКА.

ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В

МИРЕ

,

38

(6), 21-31.

67.

Axmedov, S. (2025). ВАЖНЫЕ СВОЙСТВА ПРЕПАРАТА ЭСКУЗАН ПРИ

СОСУДИСТЫХ ЗАБОЛЕВАНИЯХ.

Modern Science and Research

,

4

(1), 380-387.

68.

Эргашов,

Б.

К.

(2024).

ГИПЕРТОНИЧЕСКАЯ

БОЛЕЗНЬ

ДИАГНОСТИКА.

ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В

МИРЕ

,

38

(6), 70-78.

69.

Komilovich, E. B. (2024). HYPERTENSION DIAGNOSTICS.

ОБРАЗОВАНИЕ НАУКА

И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ

,

38

(6), 42-49.

70.

Xusenovich, M. S., & Turаpjаnovnа, Z. M. (2024). SEMIZLIKNING TURLI

FENOTIPLARDA

KARDIOMETABOLIK

XAVF

OMILLARINI

TAQQOSLASH.

SO‘NGI ILMIY TADQIQOTLAR NAZARIYASI

,

7

(4), 112-116.

71.

Husenovich, M. S., & Turabdjanovna, Z. M. (2024). STUDY OF DIURNAL PROFILE

OF

ARTERIAL

HYPERTENSION

IN

DIFFERENT

PHENOTYPE

OBESITY.

образование наука и инновационные идеи в мире

,

43

(1), 129-131.

72.

Xusenovich, M. S. (2024, September).

SEMIZLIKNI TURLI FENOTIPLARIDA YURAK

QON-TOMIR KASALLIKLARINI KELIB CHIQISH XAVFI PROGNOZI. In

INTERNATIONAL

SCIENTIFIC RESEARCH CONFERENCE

(Vol. 3, No. 26, pp. 15-18).


background image

358

ResearchBib IF - 11.01, ISSN: 3030-3753, Volume 2 Issue 3

73.

Xusenovich, M. S. (2024). O ‘ZBEKISTONDA RESPUBLIKASIDA YURAK-QON

TOMIR KASALLIKLARI TARQALISHI VA HOZIRGI KUNDAGI KO’RILAYOTGAN

CHORA TADBIRLAR.

AMERICAN JOURNAL OF SOCIAL SCIENCE

,

2

(3), 79-82.

74.

Xusenovich, M. S., & Allayarovich, A. A. (2024). O ‘ZBEKISTONDA YURAK-QON

TOMIR

KASALLIKLARI

TARQALISHI

VA

HOZIRGI

KUNDAGI

TENDENSIYASI.

MODELS AND METHODS FOR INCREASING THE EFFICIENCY

OF INNOVATIVE RESEARCH

,

4

(38), 54-57.

75.

Ravshanovna, X. L. (2021, June). MINIMALLY INVASIVE METHODS OF

TREATMENT OF DENTAL CARIES IN ADULTS. In

" ONLINE-CONFERENCES"

PLATFORM

(pp. 118-119).

76.

Axmedov, S. (2025). SPECIFIC PROPERTIES OF ROXERA DRUG IN

CARDIOVASCULAR DISEASES.

Modern Science and Research

,

4

(2), 472-479.

References

Saodat, A., Vohid, A., Ravshan, N., & Shamshod, A. (2020). MRI study in patients with idiopathic cokearthrosis of the hip joint. International Journal of Psychosocial Rehabilitation, 24(2), 410-415.

Axmedov, S. J. (2023). EFFECTS OF THE DRUG MILDRONATE. Innovative Development in Educational Activities, 2(20), 40-59.

Jamshidovich, A. S. (2023). ASCORBIC ACID: ITS ROLE IN IMMUNE SYSTEM, CHRONIC INFLAMMATION DISEASES AND ON THE ANTIOXIDANT EFFECTS. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 3(11), 57-60.

Jamshidovich, A. S. (2023). THE ROLE OF THIOTRIAZOLINE IN THE ORGANISM. Ta'lim innovatsiyasi va integratsiyasi, 9(5), 152-155.

Jamshidovich, A. S. (2023). HEPTRAL IS USED IN LIVER DISEASES. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 35(3), 76-78.

Jamshidovich, A. S. (2023). EFFECT OF TIVORTIN ON CARDIOMYOCYTE CELLS AND ITS ROLE IN MYOCARDIAL INFARCTION. Gospodarka i Innowacje., 42, 255-257.

Jamshidovich, A. S. (2024). NEUROPROTECTIVE EFFECT OF CITICOLINE. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(1), 1-4.

Jamshidovich, A. S. (2024). THE ROLE OF TRIMETAZIDINE IN ISCHEMIC CARDIOMYOPATHY. Journal of new century innovations, 44(2), 3-8.

Jamshidovich, A. S. (2024). ВСЕ ЭФФЕКТЫ ПРЕПАРАТА ИМУДОН. TADQIQOTLAR, 31(2), 39-43.

Jamshidovich, A. S. (2024). SPECIFIC FEATURES OF THE EFFECT OF THE HEPARIN DRUG. TADQIQOTLAR, 31(2), 34-38.

Jamshidovich, A. S. (2024). USE OF GLUCOCORTICOSTEROIDS IN PEDIATRIC PRACTICE. TADQIQOTLAR, 31(2), 29-33.

Jamshidovich, A. S. (2024). РОЛЬ ИНТЕЛЛАНОВОГО СИРОПА И ЦИАНОКОБАЛАМИНА В УЛУЧШЕНИИ ПАМЯТИ. TADQIQOTLAR, 31(2), 44-48.

Jamshidovich, A. S. (2024). TREATMENT OF POLYNEUROPATHY WITH BERLITHION. Ta'limning zamonaviy transformatsiyasi, 4(1), 201-209.

Jamshidovich, A. S. (2024). USE OF ASCORIL IN BRONCHIAL ASTHMA. Ta'limning zamonaviy transformatsiyasi, 4(1), 191-200.

Jamshidovich, A. S. (2024). THE IMPORTANCE OF THE DRUG ARTOXAN. Ta'limning zamonaviy transformatsiyasi, 4(1), 182-190.

Jamshidovich, A. S. (2024). THE ROLE OF RENGALIN IN CHRONIC BRONCHITIS. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 38(4), 116-123.

Jamshidovich, A. S. (2024). THE ROLE OF ALMAGEL DRUG IN GASTRIC AND DUODENAL WOUND DISEASE. Ta'limning zamonaviy transformatsiyasi, 4(1), 173-181.

Jamshidovich, A. S. (2024). THE ROLE OF CODELAK BRONCHO SYRUP IN CHILDREN'S PRACTICE. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 38(4), 109-115.

Jamshidovich, A. S. (2024). THE AEVIT DRUG EFFECT. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 38(4), 124-132.

Jamshidovich, A. S. (2024). THE IMPORTANCE OF ALCHEBA DRUG IN POST-STROKE APHASIA. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 38(4), 132-138.

Jamshidovich, A. S. (2024). THE ROLE OF HYALURON CHONDRO DRUG IN OSTEOARTHROSIS. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 38(4), 139-145.

Jamshidovich, A. S. (2024). EFFECT OF SIMETHICONE DROP IN FLATULENCE. Лучшие интеллектуальные исследования, 14(1), 95-101.

Jamshidovich, A. S. (2024). BENEFITS OF BETADINE SOLUTION. Лучшие интеллектуальные исследования, 14(1), 116-122.

Jamshidovich, A. S. (2024). EFFECT INHALED GLUCOCORTICOIDS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND BRONCHIAL ASTHMA. TADQIQOTLAR, 31(1), 171-180.

Jamshidovich, A. S. (2024). USE OF VIGANTOL IN RICKETS. Лучшие интеллектуальные исследования, 14(1), 102-108.

Jamshidovich, A. S. (2024). THE VITAPROST DRUG RESULTS. Лучшие интеллектуальные исследования, 14(1), 109-115.

Jamshidovich, A. S. (2024). THE ROLE OF BISEPTOL DRUG IN URINARY TRACT DISEASE. Лучшие интеллектуальные исследования, 14(1), 89-94.

Jamshidovich, A. S. (2024). PROPERTIES OF THE DRUG DORMIKIND. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 38(5), 88-92.

Jamshidovich, A. S., & Komilovich, E. B. (2024). IMMUNOMODULATORY FUNCTION OF DIBAZOL DRUG. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 38(5), 83-87.

Jamshidovich, A. S., & Komilovich, E. B. (2024). ADVANTAGES OF THE DRUG HEPTRAL. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 38(5), 98-101.

Эргашов, Б. К., & Ахмедов, Ш. Ж. (2024). ГИПЕРТОНИЧЕСКАЯ БОЛЕЗНЬ ЭТИОЛОГИЯ. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 38(6), 59-69.

Komilovich, E. B., & Jamshidovich, A. S. (2024). HYPERTENSION, CLASSIFICATION AND PATHOGENESIS. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 38(6), 50-58.

Komilovich, E. B., & Jamshidovich, A. S. (2024). YURAK ISHEMIYASI. STENOKARDIYADA SHOSHILINCH TIBBIY YORDAM. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 38(6), 12-20.

Komilovich, E. B., & Jamshidovich, A. S. (2024). HYPERTENSION ETIOLOGY. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 38(6), 32-41.

Komilovich, E. B., & Jamshidovich, A. S. (2024). CARDIAC ISCHEMIA. ANGINA NURSING DIAGNOSIS AND CARE. Journal of new century innovations, 46(1), 44-52.

Jamshidovich, A. S. (2024). IMPORTANT INDICATIONS OF THE DRUG WOBENZYM. Journal of new century innovations, 46(1), 29-32.

Jamshidovich, A. S. (2024). THE RESULTS OF THE EFFECT OF THE DRUG VALIDOL. Journal of new century innovations, 46(1), 19-23.

Jamshidovich, A. S. (2024). VIFERON USE IN CHILDREN. Journal of new century innovations, 46(1), 24-28.

Jamshidovich, A. S. (2024). USE OF DUSPATALIN (MEBEVERINE HYDROCHLORIDE) IN GASTROINTESTINAL DISEASES. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 38(5), 93-97.

Jamshidovich, A. S. (2024). ЭФФЕКТЫ СИРОПА ДЕПАКИНА (ВАЛЬПРОЕВАЯ КИСЛОТА). Ta'lim innovatsiyasi va integratsiyasi, 14(2), 148-152.

Jamshidovich, A. S., & Komilovich, E. B. (2024). THE IMPORTANCE OF THE DRUG ALLOCHOL FOR CHRONIC CHOLECYSTITIS. Ta'lim innovatsiyasi va integratsiyasi, 14(2), 133-137.

Jamshidovich, A. S., & Komilovich, E. B. (2024). ВАЖНЫЕ СВОЙСТВА ПРЕПАРАТА ДЕ-НОЛ (субцитрат висмута). Ta'lim innovatsiyasi va integratsiyasi, 14(2), 143-147.

Jamshidovich, A. S., & Komilovich, E. B. (2024). SPECIAL FEATURES OF BUDECTON DRUG. Ta'lim innovatsiyasi va integratsiyasi, 14(2), 138-142.

Jamshidovich, A. S. (2024). ЭФФЕКТИВНОЕ ВОЗДЕЙСТВИЕ ПРЕПАРАТА КЕЙВЕР. Ta'lim innovatsiyasi va integratsiyasi, 15(3), 137-143.

Jamshidovich, A. S. (2024). USEFUL PROPERTIES OF THE DRUG YODOFOL. Ta'lim innovatsiyasi va integratsiyasi, 15(3), 144-149.

Jamshidovich, A. S. (2024). FITOTERAPIYANING AKUSHER-GINEKOLOGIYADA AHAMIYATI. Лучшие интеллектуальные исследования, 15(2), 121-125.

Jamshidovich, A. S. (2024). THE IMPORTANCE OF THE DRUG DOPROKIN. Лучшие интеллектуальные исследования, 15(2), 109-114.

Jamshidovich, A. S. (2024). THE EFFECT OF DOSTINEX ON THE BODY. Лучшие интеллектуальные исследования, 15(2), 115-120.

Jamshidovich, A. S. (2024). РЕЗУЛЬТАТЫ ЭФФЕКТИВНОГО ДЕЙСТВИЯ ПРЕПАРАТА КАНЕФРОН. Лучшие интеллектуальные исследования, 15(2), 138-143.

Jamshidovich, A. S. (2024). СОВРЕМЕННЫЕ ЭФФЕКТЫ ПРЕПАРАТА ИНДОЛ. Лучшие интеллектуальные исследования, 15(2), 126-131.

Jamshidovich, A. S. (2024). EFFECT OF ISMIZHEN DRUG ON BODY IMMUNITY. Лучшие интеллектуальные исследования, 15(2), 132-137.

Jamshidovich, A. S. (2024). POSITIVE EFFECTS OF THE DRUG CARCIL. Ta'lim innovatsiyasi va integratsiyasi, 15(3), 127-131.

Jamshidovich, A. S. (2024). PЕЗУЛЬТАТЫ ЭФФЕКТИВНОГО ДЕЙСТВИЯ KАВИНТОНА. Ta'lim innovatsiyasi va integratsiyasi, 15(3), 132-136.

Jamshidovich, A. S. (2024). Современный Эффект Спрея Мометазон. Research Journal of Trauma and Disability Studies, 3(3), 62-65.

Jamshidovich, A. S. (2024). THE ROLE OF" SIMONTE PLUS" DRUG IN THE MODERN TREATMENT OF BRONCHIAL ASTHMA. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(5), 66-70.

Jamshidovich, A. S. (2024). FEATURES OF THE BIOMECHANISM OF THE DRUG LEVOMYCETIN (CHLORAMPHENICOL). EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(9), 298-301.

Jamshidovich, A. S. (2024). THE MOST IMPORTANT INDICATORS OF OMEGA 3 SUBSTANCE IN THE METABOLISM OF THE HUMAN BODY. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(10), 113-117.

Komilovich, E. B., & Khalimovich, M. N. (2024). CARDIAC ISCHEMIA. ANGINA CLINICAL FORMS AND DIAGNOSIS. Journal of new century innovations, 46(1), 70-78.

Komilovich, E. B. (2024). CORONARY HEART DISEASE. ANGINA EMERGENCY CARE. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 38(7), 235-242.

Komilovich, E. B. (2024). YURAK ISHEMIK KASALLIGI. STENOKARDIYANI DAVOLASHNING ZAMONAVIY TAMOYILLARI. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 38(6), 3-11.

Jamshidovich, A. S. (2024). THE MOST IMPORTANT BENEFITS OF GINGER FOR THE HUMAN BODY'S IMMUNITY. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 4(11), 269-273.

Axmedov, S. (2024). THE SPECIFIC EFFECT OF THE DRUG" BAKLASAN" IN CEREBROVASCULAR DISEASES AND ITS PRACTICAL SIGNIFICANCE TODAY. Modern Science and Research, 3(12), 485-492.

Komilovich, E. B. Z. (2023). Coronary Artery Disease. EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE, 3(12), 81-87.

Komilovich, E. B. (2024). CORONARY HEART DISEASE. ANGINA TREATMENT. Journal of new century innovations, 46(1), 95-104.

Komilovich, E. B. (2024). HYPERTENSION TREATMENT. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 38(7), 227-234.

Эргашов, Б. К. (2024). ИШЕМИЧЕСКАЯ БОЛЕЗНЬ СЕРДЦА. СТЕНОКАРДИЯ ПРОФИЛАКТИКА. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 38(6), 21-31.

Axmedov, S. (2025). ВАЖНЫЕ СВОЙСТВА ПРЕПАРАТА ЭСКУЗАН ПРИ СОСУДИСТЫХ ЗАБОЛЕВАНИЯХ. Modern Science and Research, 4(1), 380-387.

Эргашов, Б. К. (2024). ГИПЕРТОНИЧЕСКАЯ БОЛЕЗНЬ ДИАГНОСТИКА. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 38(6), 70-78.

Komilovich, E. B. (2024). HYPERTENSION DIAGNOSTICS. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 38(6), 42-49.

Xusenovich, M. S., & Turаpjаnovnа, Z. M. (2024). SEMIZLIKNING TURLI FENOTIPLARDA KARDIOMETABOLIK XAVF OMILLARINI TAQQOSLASH. SO‘NGI ILMIY TADQIQOTLAR NAZARIYASI, 7(4), 112-116.

Husenovich, M. S., & Turabdjanovna, Z. M. (2024). STUDY OF DIURNAL PROFILE OF ARTERIAL HYPERTENSION IN DIFFERENT PHENOTYPE OBESITY. образование наука и инновационные идеи в мире, 43(1), 129-131.

Xusenovich, M. S. (2024, September). SEMIZLIKNI TURLI FENOTIPLARIDA YURAK QON-TOMIR KASALLIKLARINI KELIB CHIQISH XAVFI PROGNOZI. In INTERNATIONAL SCIENTIFIC RESEARCH CONFERENCE (Vol. 3, No. 26, pp. 15-18).

Xusenovich, M. S. (2024). O ‘ZBEKISTONDA RESPUBLIKASIDA YURAK-QON TOMIR KASALLIKLARI TARQALISHI VA HOZIRGI KUNDAGI KO’RILAYOTGAN CHORA TADBIRLAR. AMERICAN JOURNAL OF SOCIAL SCIENCE, 2(3), 79-82.

Xusenovich, M. S., & Allayarovich, A. A. (2024). O ‘ZBEKISTONDA YURAK-QON TOMIR KASALLIKLARI TARQALISHI VA HOZIRGI KUNDAGI TENDENSIYASI. MODELS AND METHODS FOR INCREASING THE EFFICIENCY OF INNOVATIVE RESEARCH, 4(38), 54-57.

Ravshanovna, X. L. (2021, June). MINIMALLY INVASIVE METHODS OF TREATMENT OF DENTAL CARIES IN ADULTS. In " ONLINE-CONFERENCES" PLATFORM (pp. 118-119).

Axmedov, S. (2025). SPECIFIC PROPERTIES OF ROXERA DRUG IN CARDIOVASCULAR DISEASES. Modern Science and Research, 4(2), 472-479.