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PHARMACOEPIDEMIOLOGICAL ANALYSIS OF THE PERFORMED
CONSERVATIVE TREATMENT IN PATIENTS WITH
CHOLELITHIASIS OF THE GERONTOLOGICAL GROUP OF ANDIJAN
Mamasaliev N.S.
Salakhidinov S.Z.
Mamasaliev Z.N.
Qalandarov D.M.
Usmonov B.U.
Andijan State Medical Institute, Uzbekistan
https://doi.org/10.5281/zenodo.15130947
Relevance.
According to the WHO, in the modern treatment and diagnostic
process of cholelithiasis (CSD) it is important, especially in individuals of the
gerontological group (75-90 years and above), not only to provide scientific
information on a certain type of treatment (surgical or conservative) and clinical
and fundamental recommendations, but also to acquire modern innovative
technologies acceptable for preventive surgery and the ability to use them. For
the advanced development of CSD surgery in the 21st century, it is important to
identify the most susceptible individuals with high or very high risk for this
pathology and their special prevention to ensure the process of early detection,
effective
and
safe
treatment
(with
proper
pharmacovigilance,
pharmacoepidemiological screening) and the prevention of not only CSD itself,
but also formidable complications of cholecystectomy, cholecystostomy,
choledochotomy,
choledochomyotomy
and
transduodenal
sphincteropapillotomy.
The aim of the study
is to study the prevalence, pharmacoepidemiology of
cholelithiasis and its main risk factors among the male and female unorganized
population of the gerontological group of the Fergana Valley to enable
scientifically based planning and optimization of early diagnosis, prevention and
treatment of this disease.
The object of the study
was a contingent of 4,500 individuals of the
gerontological age population, formed using random number tables based on the
nominal electoral lists of men and women in three regions of the Fergana Valley;
as well as 779 patients with cholelithiasis who were undergoing inpatient
treatment in the regional multidisciplinary hospitals of Andijan, Namangan and
Fergana (for VEN analysis).
The subject of the study:
were the results of general clinical and
biochemical
blood
tests,
survey,
physical,
instrumental
and
THEORETICAL ASPECTS IN THE FORMATION OF
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pharmacoepidemiological monitoring; as well as the method of "daily nutrition
reproduction" adapted to the peculiarities of Uzbek cuisine.
Research methods.
To solve the set tasks, epidemiological, clinical,
laboratory, biochemical, instrumental, pharmacoepidemiological and statistical
research methods were used, as well as the “daily nutrition reproduction”
method.
Results of the study
pharmacoepidemiological analysis of the performed
conservative treatment in patients with cholelithiasis of the gerontological
group of Andijan.
Conservative strategy is used in 11.1% of men and 88.9% of women with
cholelithiasis of the gerontological group of Andijan.
It is noted that antihypertensive therapy is used in 1.39% of men and 6.9%
of women, i.e. in 8.3% of cases in patients of gerontological age of Andijan with
cholelithiasis conservative therapy is used (
ꭓ
2=0.741; P>0.05; RR=1.800; 95%
CI=1.003-3.229). Antispasmodics are used in 13.9% of cases, in 1.39% of men
and 12.5% of women with cholelithiasis (
ꭓ
2=12.80; P<0.001; RR=0.111; 95%
CI=0.017-0.722). In the group of patients ≥ 60 – 90 years old, men and women
with cholelithiasis, analgesics are taken by 13.9%, 1.39% and 12.5%,
respectively (
ꭓ
2=12.80; P<0.001; RR=0.11; 95% CI=0.017-0.722). Similar
indicators regarding the use of antibacterial drugs, enzyme inhibitors, infusion
agents and anticoagulants are confirmed in the treatment of cholelithiasis in
gerontologically aged individuals in Andijan (
ꭓ
2=12.80; P<0.001; RR=0.111;
95% CI=0.017-0.722).
As a conservative therapy for cholelithiasis, NSAIDs are used in 4.2% of
cases, in 1.39% of men and in 2.8% of women ≥ 60 – 90 years with cholelithiasis
(
ꭓ
2=2.593; P>0.05; RR=4.500; 95% CI=1.326-15.28). In patients with
cholelithiasis, proton inhibitors are used with a frequency of 1.39%, 12.5%, and
13.9%, respectively, in men, women, and the entire population ≥ 60–90 years of
age in the Andijan region.
In general, in the gerontological group of the population with cholelithiasis
in Andijan, the basic drug therapy conducted in 97.0% of cases corresponds to
modern international recommendations, its gender difference is insignificant – it
is observed only in 3.0% of cases
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