THEORETICAL ASPECTS IN THE FORMATION OF
PEDAGOGICAL SCIENCES
International scientific-online conference
73
STUDY OF THE RELATIONSHIP BETWEEN LIVER BIOCHEMICAL
INDICATORS AND BIOMARKERS OF CONNECTIVE TISSUE
DESTRUCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS
Xadjimatova I.X.
Karimov M.Sh.
Tashkent Medical Academy, Tashkent, Uzbekistan
https://doi.org/10.5281/zenodo.15280516
Introduction:
Rheumatoid arthritis is one of the most common pathologies
in the world. According to statistics, it occurs from 6-10% in men, 20-25% in
women in Uzbekistan and it affects mainly the female half of the population.
Also, great importance should be given to the state of the liver in this
autoimmune nature, in particular the general biochemical activity of the liver.
Recently, the book has increasingly been conducting scientific research devoted
to the study of the state of the liver and the hepatobiliary system. According to
some authors, the addition of pathological abnormalities in the hepatobiliary
system significantly affects the quality of life of patients with systemic diseases,
especially rheumatoid arthritis.
Target:
to study and compare the biochemical function of the liver against
the background of an increase in matrix metalloproteinase 9 in patients with
rheumatoid arthritis.
Materials and methods:
The study was conducted on the basis of the
multidisciplinary clinic of the TMA Department of Rheumatology and the
National Medical Center. The study material consisted of a total of 30 male and
female patients with signs of rheumatoid arthritis aged from 40 to 76 years. The
patients had previously been diagnosed with rheumatoid arthritis. The study
was based on the collection of complaints, anamnesis (anamnesis morbi,
anamnesis vitae), study of the patient's medical history, determination of CBC,
biochemical blood test, that is, determination of markers of liver inflammation,
immunological blood test, that is, determination of the level of MMP 9 in the
blood serum using enzyme-linked immunosorbent assay (ELISA), determining of
interleukin 1 and 6 levels in blood serum using ELISA. The RA degree activity
index was assessed using DAS-28. To assess the general condition of the liver, all
patients underwent an ultrasound examination of the liver with a mandatory
assessment of the presence of damage to the structure of the liver parenchyma,
changes in its shape and size, and the presence of changes in the biliary system.
Ultrasound examination of the liver was performed using an ACUSON NX3
device from Siemens. The results were processed using Microsoft Office Excel
2019.
THEORETICAL ASPECTS IN THE FORMATION OF
PEDAGOGICAL SCIENCES
International scientific-online conference
74
Results obtained:
Of the 30 patients with RA, 26 (85%) patients had
complaints about the general condition of the liver, such as pain of various types
in the right hypochondrium and in the Choffard area. The results of laboratory
blood tests showed that 28 (93%) patients had high levels of inflammation
markers (ALT, AST, C-reactive protein), 29 (95%) patients had high levels of
MMP-9, and 28 (93%) patients had increased interleukin 1 and 6. When
analyzing the ultrasound data, it was revealed that 78% of patients had
structural heterogeneity, liver compaction and hepatomegaly, 65% of patients
had dilation of the diameter of intrahepatic vessels, multiple small focal
compactions (55%), and changes in the gallbladder (30%). This suggests that
more than half of patients with long-term rheumatoid arthritis have abnormal
liver function, suggesting that high levels of joint destruction biomarkers are
likely to be associated with liver biochemical function.
Conclusions:
Thus, it was found that elevated levels of matrix
metalloproteinase 9 and biochemical liver parameters are interconnected, as
evidenced by the direct correlation of the results of blood serum tests in patients
with rheumatoid arthritis.
