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FEATURES OF IMMUNE STATUS AND POSSIBILITIES OF
IMMUNOCORRECTION IN RECURRENT HERPETIC STOMATITIS
Yuldasheva N.A., Abdukhakimova M.B.
Tashkent state dental Institute, Uzbekistan
Relevance of the topic.
According to the statistics of the World Health
Organization, the leading role among diseases of the oral mucosa belongs to the
pathology of herpetic nature. To date, 2/3 of the world’s population is affected by
herpes virus infection, and antibodies to HSV are detected in 85% under the age
of 50, which is direct evidence of the growing relevance of this topic. Herpes viral
pathology is not only a medical, but also a social problem, due to the ubiquitous
spread of the studied virus, persistence in the div throughout a human’s life,
significant polymorphism of clinical manifestations, affecting almost all human
organs and systems, torpidity to existing and applied methods of therapy , as well
as the location of the virus in the nerve ganglia in the form of viral DNA, which
gives us the right to deny the existence of a treatment method that could
completely eliminate HSV from the human div.
Target
.
Identifying the features of the response of the immune system in
patients with severe recurrent herpetic stomatitis based on the results of a
comprehensive clinical, laboratory and immunological examination, to formulate
a pathogenetically substantiated systematic plan for immunocorrective therapy.
Tasks
.
Studying the features of the state of the oral mucosa in herpetic
stomatitis at the beginning of the disease and during treatment, developing a
pathogenetically substantiated immunocorrection scheme during the course of
the disease.
Materials and methods.
We studied 10 people with a severe degree of
recurrent herpetic stomatitis (5 men and 5 women) aged 18 to 70 years. The
duration of the disease varied from 6 months to 10 years. In the patients was
observed the clinic of intoxication (febrile temperature, headache, chills, regional
lymphadenitis, low appetite, pain when opening the mouth). In the main group of
patients with recurrent herpetic stomatitis, a clinical and laboratory examination,
a cytological examination of the contents of the vesicles, and an immunological
examination were carried out.
Results
.
A comprehensive treatment was developed based on the data
which was studied. It allows improving the quality of life of patients with severe
recurrent herpetic stomatitis due to the speedy leveling of general and local
clinical manifestations and relief of all symptoms of the disease, reducing the time
of epithelialization and restoring indicators of general and local immunity, as well
as achieving stable and long¬term latent period of herpes infection.
Conclusions. It should be noted that the inclusion of an immunomodulatory
to the treatment regimen for patients with recurrent herpetic stomatitis is
marked by a pronounced clinical effect, the basis of which is the regulation of
systemic and local immunity and a decrease in the intensity of the inflammatory
process.
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References:
1.
Житкова
Л
.A., et al.
«Современные аспекты этиолопш, патогенеза,
клиники, диагностики и лечения хронического афтозного стоматита»
.
Здравоохранение Дальнего Востока 1.75 (2018): 44
–46.
2.
Ибрагимова, Малика, and Нпгора Убайдуллаева. «Биохимические
изменения при хроническом рецидивирующем афтозном стоматите
орофаринп1албноп области у пациентов с хроническим холециститом»
.
Медицина
и
инновации
1.4 (2021): 547–551.
IMPROVEMENT OF COMPLEX TREATMENT OF HERPETIC STOMATITIS
Isroilova M.
Master of the Department of Hospital Therapeutic Dentistry
Scientific supervisor: Yuldasheva N. A.
Tashkent state dental Institute, Uzbekistan
The problem of treatment of diseases of the oral mucosa is one of the urgent
tasks of practical dentistry. Despite the achievements of modern science, the
effectiveness of most drugs and methods of treating OS remains at an insufficient
level. It is important to take into account the fact that in the presence of a
sufficiently effective drug, it is very important to choose the optimal dosage for
each patient individually, as well as to evaluate the pharmacodynamic properties
of the drug during treatment, since at this time it is sometimes possible to activate
or inhibit the adaptive mechanisms of the div. It should also be noted that the
emergence of drug resistance in bacteria is a constant obstacle to the effective
treatment of OS diseases.
According to WHO, from 90 to 100% of the world’s population is infected
with herpes simplex viruses (HSV) types 1 and 2. This is mainly due to the
introduction of new medical technologies and a significant increase in the number
of patients with immunodeficiency, manifested in children by the development of
a dysbiotic state of the oral cavity.
Target
. Study of the effectiveness of the biological active additive Proposol
Spray in the complex treatment of patients with herpetic stomatitis and the
therapeutic effect of photodynamic therapy with the Duna apparatus.
Materials and methods.
The presence of complaints of headache, nausea
was revealed. Examined the skin, which could be pale. Body temperature could
rise up to 38°. At the peak of the rise in temperature, increased hyperemia and
pronounced swelling of the oral mucosa, elements of the lesion were found. The
number of elements of the lesion was counted and the number of relapses per
year was determined.
In the treatment of the 1 st group, the traditional therapy regimen was used:
Local therapy included painkillers before and after meals, irrigation of the oral
cavity with a solution of chlorhexidine (1:1 with distilled water up to 3 times a
