77
0-34
ANTIULCER ACTIVITY OF A NEW DERIVATIVE OF GLYCYRRHIZIC
ACID
K.T. MIRZAAHMEDOVA, A. SALAHIDDIN
Department of pharmacology and physiology, Tashkent pediatnc medical Institute, Republic of Uzbekistan;
The search for new sources of highiy active drugs based on iocai raw materials is an urgent task of
modern science, it is known that iicorice root is widely used in various sectors of the economy, the main
component of it is glycyrrhizic acid. The presence of anti-inflammatory activity, iow toxicity and iack
serious side effects make new synthetic derivative of glycyrrhizic acid promising for medicine compounds.
The purpose of the study.
To study the antiulcer activity glycerinate on an experimental model of
neurogenic uicers caused by 24-hour immobilization of animals and to identity the mechanism of antiulcer
activity.
Materials and methods.
Experimental model of neurogenic uicers caused by 24-hour immobilization of
animals were performed in rats. In the experimental groups daily for a week to stress, was oraiiy given
glycerinate at a dose of 100 mg/kg in the control group in the corresponding the volume of distiiied water.
The effect of the drug was compared with Cimetidine, which was administered in the dose of 400 mg/kg.
After 24 hours aii animais were macroscopically deceptional and watched the gastric mucosa and
evaluated the effect of antiulcer drugs. Studied the effect of giycitrinate on the secretory function of the
stomach and gastric acidity in rats. The drug was administered oraiiy during the week, 20 min after the
iast injection, the pyiorus was pervasively under ether anesthesia. Then after 2-3 hours the animals are
sacrificed and measured the volume of gastric juice was titrated
with
0.1 N NaOH solution until pink
staining. In the biood serum of rats was determined by the activity of the enzyme superoxide dismutase
(SOD) and catalase.
The results of the study.
The experiments showed that in the control group of rats the average number
of uicers 5.66±0.54, and the average total area of the uicers of 6.33±0.54 mm
;
. Under the influence of the
drug glycitrinat the average number of uicers and average total area of the uicers was reduced by
2.33±0.18 and 2.0±0.18 (58% and 68%). Under the influence of Cimetidine, the average number of uicers
and average total area was decreased by 4.66±0.36 and 3.33±0.54 (18% and 48%), respectively,
compared with the control group. To understand the mechanism of antiulcer action studied the effect of
giycitrinat on the secretory function of the stomach and gastric acidity in rats. The resuits of the
experiments showed that in the control group of rats volume of gastric juice made up 2.05 mi, pH = 1.33,
total acidity 0.5 mi, titratable unit was 100 TU. Under the influence of the drug volume of gastric juice was
reduced to 39%, pH 3.25, total acidity -0.37, titratable unit -74 TU. The development of ulcerative process
proceeded on the background of reducing the activity of antioxidant enzymes superoxid dismutas [of
1.07(1,0±1.14)] and catalas [1.41(0.94±1.88)]. Glycitrinat increased the activity of catalas compared
with
control 3.3-
times [4.76(1,96±7.6)], superoxid dismutas [1.24(1.14±1.34)]. Thus, under the action of the
drug the pH shifted to the alkaline side 1,4-times, reduced total acidity by 26%.
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