376
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
ʼ
PEROVSKIA KUDRJASCHEVII
–
A PROMISING SOURCE OF BIOLOGICALLY
ACTIVE TERPENOIDS
Ikromova G. M.
1
BotirovE. Kh.
2
1
Namangan State University, Namangan, Republic of Uzbekistan,
e-mail: gulnoza.ikromova2298@gmail.com, phone (+998) 99 398 22 98
2
Institute of Plant Chemistry named after academician S.Yu. Yunusov, AS RUz, Tashkent
https://doi.org/10.5281/zenodo.17339069
Relevance: Perovskia kudrjaschevii
Gorschk. & Pjataeva (family Lamiacaeae) is a medicinal,
essential oil, dye and honey plant. It is found in Uzbekistan, Tajikistan and Kyrgyzstan. The chemical
composition of the components of
Perovskia kudrjaschevii
has not been previously studied.
Purpose of the study
. Isolation and study of biologically active components of the above-
ground part and roots of
Perovskia kudrjaschevii,
collected in the Bostandyk district of the Tashkent
region.
Materials and methods.
Crushed air-dried plant materials were extracted five times at room
temperature with methanol. The combined extract was evaporated in vacuo, diluted with water and
subjected to liquid-liquid extraction with benzene, chloroform, ethyl acetate and n-butanol.
Results.
Two phenolic carboxylic acids, one diterpenoid and two phytosterols were isolated
from different fractions of the methanol extract of the aerial parts by column chromatography on
silica gel and Sephadex LH-20. Based on the study of UV,
1
H and
13
C NMR spectra the isolated
substances were identified with caffeic and rosmarinic acids, ferruginol, β-sitosterol and stigmasterol.
Fourteen individual compounds were isolated from the methanol extract of the roots by column
chromatography on silica gel and Sephadex LH-20. Based on the study of UV,
1
H and
13
C NMR
spectra the isolated substances were identified with the bis-nor-diterpenoid przewalskin, nor-
ditepenoids cryptotanshinone and tanshinone IIA, ditepenoids 7α-acetoxy- roileanone and sujiol,
triterpenoids erythrodiol 3β-acetate, olean-12-ene-3β-O-acetyl-28-al, oleanolic acid and oleanolic
acid 3-acetate. In addition to the above compounds, β-sitosterol, stigmasterol, caffeic and rosmarinic
acids were isolated and identified from the roots. The spatial structure of 7α-acetoxyroileanone,
erythrodiol 3β-acetate and olean-12-ene-3β-O-acetyl-28-al was established by X-ray diffraction
analysis (XRD). The XRD materials of the above compounds were deposited at the Cambridge
Crystallographic Data Centre.
All the isolated compounds have a diverse spectrum of pharmacological properties.
Cryptotanshinone is characterized by anticancer, anti-inflammatory, immunoregulatory,
neuroprotective and antifibrotic activity. Cryptotanshinone exhibits a pronounced anti-inflammatory
effect in the experiment, suppressing both the exudative and proliferative phases of inflammation. In
terms of the severity of its action, cryptotanshinone has shown certain advantages over diclofenac.
Tanshinone IIA dilates coronary arteries and increases coronary blood flow due to the activation of
potassium channels, has a cardioprotective and anti-inflammatory effect.
Conclusions.
It has been shown that the
Perovskia kudrjaschevii
plant is a rich source of
biologically active phenolic carboxylic acids, diterpenoids, triterpenoids and can be used to create
effective drugs and dietary supplements.
