497
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
FEATURES OF THERAPY WITH HERBAL PRODUCTS OF BELLADONNA
(
ATROPA BELLADONNA L.
)
Akhmadjonov K.K.
Azamatov A.A.
Ergasheva M.J.
State Institution "The center for pharmaceutical products safety" under the Ministry of Health
of the Republic of Uzbekistan, Tashkent city, Republic of Uzbekistan
e-mail: dr.k17111998@gmail.com
https://doi.org/10.5281/zenodo.17343235
Relevance.
Belladonna
,
being
perennial plant,
It is considered widespread throughout Asia
Minor. The plant material is harvested primarily in plantations, the leaves during flowering, and the
herb during fruit ripening. Belladonna roots are of interest as the primary raw material for therapeutic
agents. All parts of the plant are poisonous and contain the alkaloids atropine, scopolamine, and
hyoscyamine: 0.14-1.20% in the leaves, 0.2-0.65% in the herb, 0.24-0.6% in the flowers, and 0.7%
in the ripe fruit.
Purpose of the study.
The purpose of this study is
Study of the characteristic features of
belladonna in herbal medicine .
Materials and methods.
The main resources we used in our research were a textbook on
phytotherapy, the Atlas of Medicinal Plants of Uzbekistan, a textbook on phytotherapy, a textbook
on clinical pharmacology, and articles on the anatomical and morphological structure of the
belladonna plant, its distribution, and the collection of medicinal plant materials.
Results.
The main alkaloid of belladonna is atropine, so all pharmacological properties are
characterized by this alkaloid content. Atropine plays a significant role in its pharmacological effects
by blocking M-cholinergic receptors. In other words, it blocks nerve transmission from the end of the
postganglionic portion of the parasympathetic nerves to tissues (organs). This blocks the postsynaptic
membrane-choline receptor, located at the tissue level where the action of the neurotransmitter
acetylcholine occurs. All these properties characterize its use in medicine. Herbal preparations of
belladonna are used in ophthalmology to dilate the pupil to allow viewing of the interior of the eye,
and also to determine the degree of myopia and prescribe glasses accordingly. Belladonna
preparations are widely used for bronchial asthma, bradyarrhythmia, gastric and intestinal ulcers,
cholinomimetic poisoning, gastrointestinal colic, renal and gallstone attacks, gastrointestinal X-ray
examinations, and other conditions. Anticholinergics are not recommended for patients with
glaucoma or for elderly patients in general. Poisoning with the plant or its preparations is
accompanied by dry mouth, hoarseness, flushed skin, dryness and heat, thirst, dilated pupils,
tachycardia, etc., and an elevated div temperature. First aid measures: physostigmine salicylate
(from the anticholinesterase group) is administered at 0.001 g (in 5 ml of isotonic saline solution)
every 5 minutes (total dose 0.006 g). Prostigmine or galantamine may also be prescribed. For
psychomotor agitation, hexenal or sibazon are injected intramuscularly. For oral poisoning, gastric
lavage is performed with water containing activated charcoal; saline rinses are recommended. Rinse
your mouth, shower with cold water, or bathe in cold water, and dry yourself thoroughly.
Conclusions.
Based on our research, we can conclude that belladonna herbal preparations, due
to their atropine content, affect the peripheral nervous system through their M-anticholinergic action.
