154
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
MODERN TECHNOLOGIES FOR THE PRODUCTION AND STANDARDIZATION
OF HERBAL PHARMACEUTICAL SUBSTANCES
Seitova Zhanerke Dauletkyzy
Assistant Professor of the department of organization, management and economics of
pharmacy and clinical pharmacy
e-mail: seitova.zh@kaznmu.kz tel. +77014700048
Ashirov Murat Zulpidinovich
associate professor without academic title of the department of organization, management
and economics of pharmacy and clinical pharmacy
e-mail: ashirov.m@kaznmu.kz tel. +77754415161
https://doi.org/10.5281/zenodo.17328565
Relevance:
The development of phytopharmaceuticals requires the introduction of innovative
methods for obtaining substances from medicinal plant raw materials. Modern technologies –
supercritical Co₂ extraction, ultrasonic and microwave extraction - make it possible to increase the
yield of biologically active substances, ensure their selectivity and environmental friendliness of
processes, which meets international quality requirements.
The purpose of the study.
To summarize modern approaches to the production and
standardization of herbal pharmaceutical substances and to assess their prospects for introduction into
domestic production.
Materials and methods.
The analysis of publications in Scopus, PubMed, and Web of Science
databases (2005-2025) on extraction technologies and quality control methods was carried out.
Modern methods of quantitative analysis (HPLC, GC-MS, IR spectroscopy) and approaches to
standardization are considered.
Results.
It was found that the use of ultrasonic extraction makes it possible to increase the yield
of flavonoids by 20-35% compared with classical maceration. Supercritical Co₂ extraction ensures
the selective isolation of lipophilic components while maintaining their biological activity. For
standardization of substances, the most promising is the use of chromatographic methods in
combination with the pharmacopoeial requirements of the EAEU and the Pharmacopoeia of the
Republic of Kazakhstan.
Conclusions.
Modern extraction technologies and analytical control methods open up broad
prospects for the development of new phytopreparations. Their implementation will improve the
effectiveness and safety of herbal medicines, as well as the competitiveness of domestic
pharmaceutical products.
