528
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
THE ROLE OF PHARMACEUTICALS IN THE PREVENTION AND TREATMENT
OF DISEASES OF THE FEMALE REPRODUCTIVE SYSTEM
Ziyayeva Sh.T.
Erkenova S.D.
Tashkent State Medical University, Tashkent, Uzbekistan
https://doi.org/10.5281/zenodo.17343993
Relevance:
Modern pharmacological drugs play a key role in the prevention and treatment of
diseases of the female reproductive system, such as menstrual cycle disorders, endometriosis,
polycystic ovary syndrome (PCOS), infertility, and osteoporosis. The assessment of the effectiveness
and safety of drugs aimed at hormonal therapy, the use of drugs to improve fertility, as well as drugs
that regulate metabolism and immune reactions, is an important aspect of modern pharmacotherapy
in gynecology.
The purpose
of the study is to evaluate the effectiveness and safety of pharmacological agents
used for the prevention and treatment of diseases of the female reproductive system, with a focus on
hormonal therapy, fertility-enhancing drugs, and agents that regulate metabolism and immune
responses, in the context of their impact on women's health, improving their quality of life, and
restoring their reproductive functions.
Materials and methods:
The study used works on the pharmacodynamics and
pharmacokinetics of drugs, as well as clinical trials conducted with women suffering from
reproductive diseases. The methodology includes: analysis of scientific publications data: a
systematic review and meta-analysis of published data on the use of pharmacological agents in the
treatment of diseases of the female reproductive system. For this, the databases PubMed, Google
Scholar, Scopus and Cochrane Library were used. Pharmacokinetic modeling method: Analysis of
the pharmacokinetic properties of drugs used to treat diseases of the female reproductive system to
assess their dosage, half-life, and potential for accumulation in the div.
Discussion results:
The use of hormonal medications (such as oral contraceptives, progestins,
and hormonal inhalers) in the treatment of female reproductive system disorders, such as
endometriosis and amenorrhea, has shown significant improvement in patient conditions. These
medications are effective in normalizing the menstrual cycle, reducing pain, and reducing the risk of
complications such as infertility. However, their long-term use is associated with potential risks, such
as an increased likelihood of venous thrombosis and hormonal imbalances, which require careful
medical monitoring. Treatment of Polycystic Ovary Syndrome (PCOS): Medications for metabolic
disorders, such as insulin sensitizers (metformin), are widely used in the treatment of PCOS. Their
use helps restore normal insulin levels and improves ovulation. In combination with drugs that
regulate hormonal balance, such as clomiphene citrate, metformin improves reproductive function
and increases the likelihood of conception. However, the effectiveness of these drugs may vary
depending on the severity of the syndrome and the presence of concomitant diseases. Fertility
products: Drugs used to improve fertility (clomiphene, gonadotropins) have demonstrated high
efficacy in the treatment of female infertility, especially in cases of ovulation problems. However,
these medications do not always provide long-lasting results and may be accompanied by side effects
such as ovarian hyperstimulation. The challenges in selecting the most appropriate treatment method,
as well as the need for continuous monitoring of patient conditions, highlight the importance of an
individualized approach. While pharmacological interventions are effective, they may also cause
529
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
undesirable side effects that must be considered when prescribing therapy. For example, hormone
therapy can lead to undesirable changes in lipid metabolism, weight gain, and an increased risk of
thrombosis. This requires an individualized approach to each patient and ongoing monitoring of their
health, especially in women with a predisposition to cardiovascular diseases. Currently, there is an
active effort to develop more specific and safe pharmacological treatments for reproductive system
disorders. New drugs that target the molecular mechanisms of diseases promise to be more effective
and minimize side effects. In the future, this could lead to the development of personalized treatment
regimens for women suffering from reproductive disorders.
Conclusions:
The use of pharmacological agents in the treatment of diseases of the female
reproductive system, such as polycystic ovary syndrome (PCOS), endometriosis, infertility, and
menstrual cycle dysfunction, demonstrates high efficiency. Hormonal therapy, including oral
contraceptives and progestins, is actively used to regulate hormonal levels, reduce pain, and
normalize the menstrual cycle. Fertility-enhancing medications, such as clomiphene, gonadotropins,
and insulin sensitizers, have shown positive results in the treatment of female infertility. These
medications help restore ovulation and increase the chances of conception, particularly in women
with PCOS. However, despite their effectiveness, many of these medications may have side effects,
such as an increased risk of thrombosis with hormonal medications, as well as potential endocrine
and metabolic disorders. This requires an individualized approach to therapy and regular monitoring
of the patient's condition. The discussion highlights the need for a comprehensive approach to treating
female reproductive system disorders, which includes not only pharmacotherapy but also lifestyle
changes, dietary therapy, physical activity, and psychological support. This approach contributes to
a higher quality of life for patients and increases the likelihood of successful treatment.
