123
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
EVALUATION OF THE QUALITY AND BIOAVAILABILITY OF MEDICINAL
FILMS BASED ON ALOE EXTRACT AND METILURACIL
Tureeva G.M.
1
Abed F.J.
2
Tashkent Pharmaceutical Institute, Tashkent city, Republic of Uzbekistan
e-mail: galiya.tureeva.14@gmail.com
https://doi.org/10.5281/zenodo.17324848
Relevance:
The effective treatment of many dermatological diseases is associated with the use,
along with traditional dosage forms (ointments, gels, solutions), of modern dosage forms such as
polymeric medicinal films. The successful treatment of dermatological diseases largely depends on
the use of complex therapy, i.e. the combination in the dosage form of substances that have not only
antibacterial but also anti-inflammatory and wound-healing effect.
For the treatment of difficult-to-heal wounds, ulcers, inflammations, infected burns, and
dermatitis, the use of Aloe preparations, which have an anti-inflammatory effect and enhance the
regeneration processes of mucous membranes and skin, has proven to be promising. Among the
preparations with regenerative properties is methyluracil, which is a tissue regeneration stimulant that
helps restore the natural structure of tissues and promotes wound healing.
Based on the above, previous studies have developed the composition and technology of
dermatological phytofilms, containing a complex of Aloe extract and methyluracil.
The purpose of the study.
The aim of this study was to evaluate the quality of the obtained
phytofilms, as well as to investigate their bioavailability.
Materials and methods:
The studies used medicinal components and polymers that meet the
requirements of the RD.
The phytofilms, were obtained by the well-known solution method, by casting the film mass on
glass substrates, followed by drying at a temperature of 30-320C to the optimal residual moisture. In
the studies, the following indicators of phytofilms, were studied: appearance, ability to separate from
the substrate surface, pH value of the aqueous solution, and dissolution time according to the methods
described in the General Pharmacopoeia of the Russian Federation.1.4.1.0035.18. – Films (State
Pharmacopoeia of the Russian Federation. – 14th ed.,: 2018.) as well as in literary sources.
To study the bioavailability of phytofilms, we used a well-known method in the literature,
proposed by E.I. Kulish and A.S. Shurshina, which is the method of diffusion into a dialysis medium.
Results.
The research results showed that the obtained films were transparent, elastic, and light
yellow in color, with an average mass of 0.4 ± 0.018, and they easily separated from the substrate
surface. The films had a dissolution time of 540-720 seconds and a pH value of 6.6-7.0, respectively.
The bioavailability of phytofilms, was evaluated based on the release kinetics of the active
components: methyluracil and aloe extract in terms of barbaloin, the quantitative content of which
was determined by spectrophotometry at a wavelength of 412 nm (methyluracil) and 260 nm
(barbaloin), respectively.
According to the results obtained, the maximum concentration of active substances released
from the phytofilms, was observed after 90 minutes, which was 77.1% for methyluracil and 74.2%
for Aloe (barbaloin), respectively. It was found that a significant release of active substances was
observed within 180 minutes.
Conclusions.
The physical, chemical, and technological properties of the phytofilms, obtained
using the proposed optimal technology were studied: appearance, mass, dissolution time, and pH
124
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
value. The bioavailability of the active components in the developed phytofilms, was studied using
the in vitro method. The kinetics of the release of methyluracil and aloe extract (barbaloin) from the
phytofilms, into the dialysis medium were investigated.
