363
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
STUDY OF THE BIOLOGICAL ACTIVITY OF THE COMPLEX COMPOUND [Cu
(Tsk)
2
](Glu)
2
USING THE PASS ONLINE PROGRAM
Umirzakova O.T.
Nuraliyeva G.A.
National University of Uzbekistan, Tashkent city, Republic of Uzbekistan
e-mail: oydinoyumirzoqova@gmail.com
https://doi.org/10.5281/zenodo.17337714
Relevance of the study
. the possibility of assessing physicochemical properties directly by the
structural formula of the compound is relevant. Comparison of these parameters of the synthesized
compounds obtained as a result of calculations allows us to assess the contribution of a certain
physicochemical characteristic to the developed activity and a better understanding of the mechanism
of action of the preparation.
Purpose of the study.
Study of the structure and prediction of potential biological properties
of compounds:[Cu(Tsk)
2
](Glu)
2
.
Method and style.
Pass-online application
A powerful set of methods for predicting the biological activity of chemical compounds on a
computer is methods based on Bayesian probability. The Pass software package is a program capable
of predicting the biological activity spectra of chemical compounds known to date. The Pass program
(online) is based on the study of the biological activity of substances depending on their structure.
This program contains known Pa and Pi values for the substance, these values represent the theoretical
probability. That is, Pa is pharmacologically active, Pi is pharmacologically inactive. If Pa >0.71,
such a molecule is considered active. The online pass program works on the principle of structural
biological activity. In this case, the value of Pa determines the pharmacological activity of the
substance against a certain disease, and the value of Pi determines the low pharmacological activity
against this disease.
Results.
Computer calculations were performed using the pass-Online program to determine
potential biologically active substances. It was established that the synthesized complex compounds
have high inhibitory activity against enzymes.
Theoretically calculated biological activity of the [Cu(Tsk)
2
](Glu)
2
molecule in the PASS-
online program
Summary:
According to the results of the analysis of the Pass-online program, it was
established that [Cu(Tsk)
2
](Glu)
2
is a high inhibitor of enzyme complexes. It was established that
these complex compounds have high activity of alanine transaminase and beta-adrenergic receptor
inhibitor.
0
0,2
0,4
0,6
0,8
1
0,901
0,845 0,837 0,802
0,703 0,746 0,701
0,635
Alanin transaminaza ingibitori
Beta-adrenergik retseptorlari
ingibitori
Levanaza ingibitori
