562
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
COMPOSITION OF VARIOUS HEMATOGEN PREPARATIONS AND THE TOXIC
EFFECTS OF THEIR COMPONENTS ON THE HUMAN BODY
Muzaffarova Sh.A.
Xamdamov M.M.
Nurmatova M.I.
Tashkent pharmaceutical institute, Tashkent city, Republic of Uzbekistan
https://doi.org/10.5281/zenodo.17344382
Relevance
. One of the most common health issues observed among the population today is iron
deficiency. According to the World Health Organization (WHO), in 2023, anemia was diagnosed in
2.24 billion people worldwide, and this number continues to increase daily. In Uzbekistan, anemia
has been recorded in 17.5% of men and 31.2% of women. Iron deficiency raises the demand for iron-
containing preparations, which necessitates their production. Currently, the pharmaceutical market
offers various types of iron-containing medicines. These preparations are based on iron (Ferrum), but
they differ in their main and excipient components, as well as in their dosage forms—such as tablets,
syrups, injections, biologically active supplements, and food-like products such as bars known as
hematogen. Hematogen lat.
Haematogenum
in greek αἷμα (blood) and γένος (generation). In
medicine, it is used as a means of stabilizing blood formation. Its main component is purified albumin
or iron salts. Albumin is derived from bovine blood, purified of impurities, and dried. To improve
absorption of iron in the div, vitamins, as well as flavoring or coloring agents, may be added.
Hematogen preparations were widely sold in pharmacies in Soviet Union and enjoyed high sales.
However, during that time, the albumin used in production was often not purified and bovine blood
was directly incorporated into the product, which reportedly led to numerous bacterial infections
among the population. Based on this information, the task was set to improve the composition of the
hematogen product.
Purpose of the study.
To examine the composition of various hematogen preparations and
investigate the toxic effects of their components on the human div, providing toxicological
recommendations to prevent poisoning.
Research methods and techniques:
Current data show that the consumption of iron-
containing preparations among patients is significantly high. However, this has also led to certain
problems, including cases of iron poisoning. Literature sources indicate that some patients
particularly children may not digest iron, and in severe cases of anemia or gastrointestinal diseases,
iron absorption may be impaired, resulting in unabsorbed iron accumulation and acute poisoning
caused by iron preparations.
Results:
Different types of iron-containing hematogen preparations available on the
pharmaceutical market of Uzbekistan were studied. Imported hematogen products manufactured in
Russia, Belarus, and Ukraine, as well as locally produced preparations by INVITRIS LLC, were
analyzed for their composition. Additionally, data on appropriate measures to be taken in cases of
poisoning were collected.
Conclusion:
Iron-containing compounds should be administered strictly according to a
physician’s prescription, in the recommended dose and at the prescribed time, for patients with iron
deficiency. Since acute poisoning has been more frequently observed in children, it is important to
carefully monitor the dosage of iron-containing hematogen preparations.
